Search Results - "Osanai, Makoto"

Quantitative Activity-Induced Manganese-Enhanced Magnetic Resonance Imaging: Principles, Applications, and Limitations by Osanai, Makoto

“…Accurate identification of regions that show activity changes in response to functional expression is necessary to understand the mechanisms underlying…”
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Cellular retinoic acid bioavailability in various pathologies and its therapeutic implication by Osanai, Makoto

“…Retinoic acid (RA), an active metabolite of vitamin A, is a critical signaling molecule in various cell types. We found that RA depletion caused by expression…”
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Orchestrated ensemble activities constitute a hippocampal memory engram by Ghandour, Khaled, Ohkawa, Noriaki, Fung, Chi Chung Alan, Asai, Hirotaka, Saitoh, Yoshito, Takekawa, Takashi, Okubo-Suzuki, Reiko, Soya, Shingo, Nishizono, Hirofumi, Matsuo, Mina, Osanai, Makoto, Sato, Masaaki, Ohkura, Masamichi, Nakai, Junichi, Hayashi, Yasunori, Sakurai, Takeshi, Kitamura, Takashi, Fukai, Tomoki, Inokuchi, Kaoru

“…The brain stores and recalls memories through a set of neurons, termed engram cells. However, it is unclear how these cells are organized to constitute a…”
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Aldolase A promotes epithelial‐mesenchymal transition to increase malignant potentials of cervical adenocarcinoma by Saito, Yuki, Takasawa, Akira, Takasawa, Kumi, Aoyama, Tomoyuki, Akimoto, Taishi, Ota, Misaki, Magara, Kazufumi, Murata, Masaki, Hirohashi, Yoshihiko, Hasegawa, Tadashi, Sawada, Norimasa, Saito, Tsuyoshi, Osanai, Makoto

“…Recent studies have revealed that metabolic reprogramming is closely associated with epithelial‐mesenchymal transition (EMT) during cancer progression…”
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Retinoic acid metabolism in cancer: potential feasibility of retinoic acid metabolism blocking therapy by Osanai, Makoto, Takasawa, Akira, Takasawa, Kumi, Kyuno, Daisuke, Ono, Yusuke, Magara, Kazufumi

“…Retinoic acid (RA) is an active metabolite of vitamin A, which is an essential signaling molecule involved in cell fate decisions, such as differentiation,…”
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CYP24A1-induced vitamin D insufficiency promotes breast cancer growth by Osanai, Makoto, Lee, Gang-Hong

“…Vitamin D plays a critical role in tissue homeostasis by regulating the expression of genes affecting cell proliferation, differentiation, and apoptosis. The…”
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Vitamin D metabolism in cancer: potential feasibility of vitamin D metabolism blocking therapy by Kamiya, Sakura, Nakamori, Yuna, Takasawa, Akira, Takasawa, Kumi, Kyuno, Daisuke, Ono, Yusuke, Magara, Kazufumi, Osanai, Makoto

“…In this review, we discuss the possibility of the vitamin D metabolizing enzyme CYP24A1 being a therapeutic target for various tumors including breast,…”
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Fascin‐1 expression correlates with repression of E‐cadherin expression in hepatocellular carcinoma cells and augments their invasiveness in combination with matrix metalloproteinases by Hayashi, Yoshihiro, Osanai, Makoto, Lee, Gang‐Hong

“…Expression of fascin‐1, an actin bundling protein, is a poor prognostic factor in hepatocellular carcinoma (HCC). However, its biological role in HCC cells…”
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Aberrant expression of claudin‐6 contributes to malignant potentials and drug resistance of cervical adenocarcinoma by Ito, Yui, Takasawa, Akira, Takasawa, Kumi, Murakami, Taro, Akimoto, Taishi, Kyuno, Daisuke, Kawata, Yuka, Shano, Kodai, Kirisawa, Kurara, Ota, Misaki, Aoyama, Tomoyuki, Murata, Masaki, Sugimoto, Kotaro, Chiba, Hideki, Saito, Tsuyoshi, Osanai, Makoto

“…Recent studies have revealed that aberrant expression of tight junction (TJ) proteins is a hallmark of various solid tumors and it is recognized as a useful…”
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Gelatin–Polyaniline Composite Nanofibers Enhanced Excitation–Contraction Coupling System Maturation in Myotubes by Ostrovidov, Serge, Ebrahimi, Majid, Bae, Hojae, Nguyen, Hung Kim, Salehi, Sahar, Kim, Sang Bok, Kumatani, Akichika, Matsue, Tomokazu, Shi, Xuetao, Nakajima, Ken, Hidema, Shizu, Osanai, Makoto, Khademhosseini, Ali

“…In this study, composite gelatin–polyaniline (PANI) nanofibers doped with camphorsulfonic acid (CSA) were fabricated by electrospinning and used as substrates…”
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Editorial: Manganese-Enhanced MRI: A New Avenue of Functional and Structural Imaging in Neuroscience by Osanai, Makoto, Hikishima, Keigo, Onoe, Hirotaka

“…A New Avenue of Functional and Structural Imaging in Neuroscience To elucidate the functional circuitry underlying information processing in the brain, we need…”
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Association of medullary reticular formation ventral part with spasticity in mice suffering from photothrombotic stroke by Isumi, Shogo, Futamura, Daiki, Hanasaki, Takuto, Sako, Yukito, Miyata, Shotaro, Kan, Hirohito, Suzuki, Yumika, Hasegawa, Naoki, Mushiake, Hajime, Kametaka, Satoshi, Uchiyama, Yasushi, Osanai, Makoto, Lee-Hotta, Sachiko

“…•The mechanisms underlying spasticity following stroke are poorly understood.•Neuronal activity increased in the medullary reticular formation in mice after…”
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Pathological classification of desmoplastic reaction is prognostic factor in cervical adenocarcinoma by Akimoto, Taishi, Takasawa, Akira, Takasawa, Kumi, Aoyama, Tomoyuki, Matsuura, Motoki, Tamate, Masato, Iwasaki, Masahiro, Habata, Shutaro, Murakami, Taro, Osanai, Makoto, Saito, Tsuyoshi

“…Desmoplastic reaction (DR) and inflammation are significant pathological manifestations of tumorigenesis in several cancers. However, the correlation between…”
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Multimodal Functional Analysis Platform: 3. Spherical Treadmill System for Small Animals by Katayama, Norihiro, Nakao, Mitsuyuki, Tanaka, Tetsu, Osanai, Makoto, Mushiake, Hajime

“…In the application of advanced neuroscience techniques including optogenetics to small awake animals, it is often necessary to restrict the animal's movements…”
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Estrogen/GPR30 Signaling Contributes to the Malignant Potentials of ER-Negative Cervical Adenocarcinoma via Regulation of Claudin-1 Expression by Akimoto, Taishi, Takasawa, Akira, Takasawa, Kumi, Aoyama, Tomoyuki, Murata, Masaki, Osanai, Makoto, Saito, Tsuyoshi, Sawada, Norimasa

“…Cervical adenocarcinomas are believed to lose estrogen response on the basis of no expression of a nuclear estrogen receptor such as ERα in clinical pathology…”
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Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials by Kyuno, Daisuke, Takasawa, Akira, Takasawa, Kumi, Ono, Yusuke, Aoyama, Tomoyuki, Magara, Kazufumi, Nakamori, Yuna, Takemasa, Ichiro, Osanai, Makoto

“…Claudins are major components of tight junctions that maintain cell polarity and intercellular adhesion. The dynamics of claudins in cancer cells have…”
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Elevated expression of JAM‐A promotes neoplastic properties of lung adenocarcinoma by Magara, Kazufumi, Takasawa, Akira, Osanai, Makoto, Ota, Misaki, Tagami, Yohei, Ono, Yusuke, Takasawa, Kumi, Murata, Masaki, Hirohashi, Yoshihiko, Miyajima, Masahiro, Yamada, Gen, Hasegawa, Tadashi, Sawada, Norimasa

“…A cell–cell adhesion protein, junctional adhesion molecule‐A (JAM‐A), has been shown to be involved in neoplasia of various organs. However, the fundamental…”
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Suppression of the vitamin D metabolizing enzyme CYP24A1 provides increased sensitivity to chemotherapeutic drugs in breast cancer by Kamiya, Sakura, Nakamori, Yuna, Takasawa, Akira, Takasawa, Kumi, Kyuno, Daisuke, Ono, Yusuke, Magara, Kazufumi, Osanai, Makoto

“…Vitamin D is an essential nutrient for the human body not only for the metabolism of calcium but also for homeostasis. Vitamin D contributes to cell fate…”
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A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis by Murakami, Taro, Takasawa, Akira, Moriki, Asako, Igaki, Yusuke, Ikeda, Hiroshi, Murase, Kazuyuki, Takada, Kohichi, Magara, Kazufumi, Aoyama, Tomoyuki, Ono, Yusuke, Kyuno, Daisuke, Takasawa, Kumi, Murata, Masaki, Osanai, Makoto

“…Amyloidosis is induced by extracellular deposition of certain proteins. Thirty-six proteins have so far been identified as amyloidogenic proteins in humans…”
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Experimental phage therapy against lethal lung-derived septicemia caused by Staphylococcus aureus in mice by Takemura-Uchiyama, Iyo, Uchiyama, Jumpei, Osanai, Makoto, Morimoto, Norihito, Asagiri, Tadashi, Ujihara, Takako, Daibata, Masanori, Sugiura, Tetsuro, Matsuzaki, Shigenobu

“…Nosocomial respiratory infections caused by methicillin-resistant Staphylococcus aureus (MRSA) can progress to lethal systemic infections. Bacteriophage…”
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