Search Results - "Osamu Shimomura"

Discovery of Green Fluorescent Protein (GFP) (Nobel Lecture) by Shimomura, Osamu

“…Trip the light fantastic: The green fluorescent protein (GFP) is an invaluable tool for biochemical and medicinal research. It can make tumors, amyloid plaques…”
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Usefulness of Human Jejunal Spheroid-Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans by Michiba, Kazuyoshi, Maeda, Kazuya, Shimomura, Osamu, Miyazaki, Yoshihiro, Hashimoto, Shinji, Oda, Tatsuya, Kusuhara, Hiroyuki

“…This study aimed to demonstrate the usefulness of human jejunal spheroid-derived differentiated intestinal epithelial cells as a novel in vitro model for…”
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A Novel Therapeutic Strategy for Pancreatic Cancer: Targeting Cell Surface Glycan Using rBC2LC-N Lectin-Drug Conjugate (LDC) by Shimomura, Osamu, Oda, Tatsuya, Tateno, Hiroaki, Ozawa, Yusuke, Kimura, Sota, Sakashita, Shingo, Noguchi, Masayuki, Hirabayashi, Jun, Asashima, Makoto, Ohkohchi, Nobuhiro

“…Various cancers, including pancreatic ductal adenocarcinoma (PDAC), remain intractable even with costly tumor-targeting antibody drugs. Because the outermost…”
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Glycan expression profile of signet ring cell gastric cancer cells and potential applicability of rBC2LCN-targeted lectin drug conjugate therapy by Yang, Yu, Akashi, Yoshimasa, Shimomura, Osamu, Tateno, Hiroaki, Saito, Sayoko, Hiemori, Keiko, Miyazaki, Yoshihiro, Furuta, Tomoaki, Kitaguchi, Daichi, Kuroda, Yukihito, Pakavarin, Louphrasitthiphol, Oda, Tatsuya

“…Background Signet ring cell carcinoma (SRC) is a distinct subtype of gastric cancer (GC); however, the specific characteristics of cancer cell surface glycans…”
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Quantitative structural analysis of glycans expressed within tumors derived from pancreatic cancer patient-derived xenograft mouse models by Hasehira, Kayo, Furuta, Tomoaki, Shimomura, Osamu, Asada, Masahiro, Oda, Tatsuya, Tateno, Hiroaki

“…Pancreatic ductal adenocarcinoma (PDAC) is an intractable malignancy for which novel therapeutic targets are in high demand. To uncover glycans expressed…”
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Release behavior of a polyanion‐crosslinked chitosan‐poly(N‐isopropylacrylamide) gel thermoresponsive material by Ueoka, Hiroki, Shimomura, Osamu, Ueda, Kayoko, Inada, Katsuhiro, Nomura, Ryoki

“…ABSTRACT A novel type of temperature‐responsive hydrogel with sensitive release performance of an encapsulated compound was obtained. The…”
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Culture of circulating tumor cells using a microfilter device by Furukawa, Atsuko, Mori, Tomoko, Shimomura, Osamu, Araki, Kazuhisa, Oda, Tatsuya, Matsusaka, Satoshi

“…Circulating tumor cells (CTCs) are associated with cancer metastasis and prognosis but their scarcity in whole blood prevents their use as a diagnostic tool…”
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Carcinoembryonic antigen as a specific glycoprotein ligand of rBC2LCN lectin on pancreatic ductal adenocarcinoma cells by Furuta, Tomoaki, Oda, Tatsuya, Kiyoi, Kayo, Yusuke, Ozawa, Kimura, Sota, Kurimori, Ko, Miyazaki, Yoshihiro, Yu, Yang, Furuya, Kinji, Akashi, Yoshimasa, Shimomura, Osamu, Tateno, Hiroaki

“…The rBC2LCN lectin, known as a stem cell marker probe that binds to an H type 3 fucosylated trisaccharide motif, was recently revealed to also bind to…”
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Lectin drug conjugate therapy for colorectal cancer by Kitaguchi, Daichi, Oda, Tatsuya, Enomoto, Tsuyoshi, Ohara, Yusuke, Owada, Yohei, Akashi, Yoshimasa, Furuta, Tomoaki, Yu, Yang, Kimura, Sota, Kuroda, Yukihito, Kurimori, Ko, Miyazaki, Yoshihiro, Furuya, Kinji, Shimomura, Osamu, Tateno, Hiroaki

“…Drug resistance represents an obstacle in colorectal cancer (CRC) treatment because of its association with poor prognosis. rBC2LCN is a lectin isolated from…”
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rBC2LCN-reactive SERPINA3 is a glycobiomarker candidate for pancreatic ductal adenocarcinoma by Mawaribuchi, Shuuji, Shimomura, Osamu, Oda, Tatsuya, Hiemori, Keiko, Shimizu, Kayoko, Yamase, Kenya, Date, Mutsuhiro, Tateno, Hiroaki

“…Abstract Early detection is urgently needed to improve the patient’s pancreatic ductal adenocarcinoma (PDAC) survival. Previously, we identified a novel…”
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Lectin‐based phototherapy targeting cell surface glycans for pancreatic cancer by Kuroda, Yukihito, Oda, Tatsuya, Shimomura, Osamu, Hashimoto, Shinji, Akashi, Yoshimasa, Miyazaki, Yoshihiro, Furuya, Kinji, Furuta, Tomoaki, Nakahashi, Hiromitsu, Louphrasitthiphol, Pakavarin, Mathis, Bryan J, Nakajima, Takahito, Tateno, Hiroaki

“…Pancreatic ductal adenocarcinoma (PDAC) is resistant to current treatments but lectin‐based therapy targeting cell surface glycans could be a promising new…”
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Oxidation of Primary Amines to Nitriles Catalyzed by Polystyrene-stabilized Ru Nanoparticles in Water by Kawase, Misa, Suzuki, Ryugo, Kobayashi, Kaito, Shinagawa, Tsutomu, Tazawa, Aya, Uozumi, Yasuhiro, Matsumura, Yoshimasa, Shimomura, Osamu, Ohtaka, Atsushi

“…Primary amines were successfully oxidized to nitriles in water under mild reaction conditions in the presence of polystyrene (PS)-stabilized Ru(III)…”
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Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy by Takahashi, Kazuhiro, Gosho, Masahiko, Miyazaki, Yoshihiro, Nakahashi, Hiromitsu, Shimomura, Osamu, Furuya, Kinji, Doi, Manami, Owada, Yohei, Ogawa, Koichi, Ohara, Yusuke, Akashi, Yoshimasa, Enomoto, Tsuyoshi, Hashimoto, Shinji, Oda, Tatsuya

“…The success of liver resection relies on the ability of the remnant liver to regenerate. Most of the knowledge regarding the pathophysiological basis of liver…”
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Expression of Reaction Selectivity and the Substituent Effect in Ullmann, Suzuki, Hiyama, and Allylic Arylation Reactions Caused by Reducing Catalyst Loading by Misa Kawase, Tomohiro Shibata, Shouhei Masuu, Masaki Yamaguchi, Yoshimasa Matsumura, Osamu Shimomura, Atsushi Ohtaka

“…The control of stereo-, regio-, and chemo-selectivity in transition-metal-catalyzed coupling reactions is a key topic in organic synthesis. Several methods for…”
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Detailed Mechanism for Hiyama Coupling Reaction in Water Catalyzed by Linear Polystyrene-Stabilized PdO Nanoparticles by Sakon, Akira, Ii, Ryoma, Hamasaka, Go, Uozumi, Yasuhiro, Shinagawa, Tsutomu, Shimomura, Osamu, Nomura, Ryôki, Ohtaka, Atsushi

“…The catalytic cycle of the Hiyama coupling reaction in water catalyzed by linear polystyrene-stabilized PdO nanoparticles (PS-PdONPs) was investigated. The…”
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Catalytic specificity of linear polystyrene-stabilized Pd nanoparticles during Ullmann coupling reaction in water and the associated mechanism by Ohtaka, Atsushi, Sakon, Akira, Yasui, Asuka, Kawaguchi, Taira, Hamasaka, Go, Uozumi, Yasuhiro, Shinagawa, Tsutomu, Shimomura, Osamu, Nomura, Ryôki

“…In the present work, heterogeneous Pd nanoparticle catalysts supported on linear polystyrene (PS-PdNPs) were used to promote Ullmann coupling reactions in…”
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Retrospective analysis of neoadjuvant chemotherapy followed by surgery versus definitive chemoradiotherapy with proton beam for locally advanced esophageal squamous cell carcinoma by Ogawa, Koichi, Ishikawa, Hitoshi, Hisakura, Katsuji, Hiroshima, Yuichi, Moriwaki, Toshikazu, Yamada, Takeshi, Yamamoto, Yoshiyuki, Akashi, Yoshimasa, Owada, Yohei, Ohara, Yusuke, Enomoto, Tsuyoshi, Furuya, Kinji, Doi, Manami, Shimomura, Osamu, Takahashi, Kazuhiro, Hashimoto, Shinji, Sakurai, Hideyuki, Oda, Tatsuya

“…Background This is the first study to compare the long-term outcomes between neoadjuvant chemotherapy + surgery and definitive chemoradiotherapy with proton…”
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Cetuximab delivery and antitumor effects are enhanced by mild hyperthermia in a xenograft mouse model of pancreatic cancer by Miyamoto, Ryoichi, Oda, Tatsuya, Hashimoto, Shinji, Kurokawa, Tomohiro, Inagaki, Yuki, Shimomura, Osamu, Ohara, Yusuke, Yamada, Keiichi, Akashi, Yoshimasa, Enomoto, Tsuyoshi, Kishimoto, Mikio, Yanagihara, Hideto, Kita, Eiji, Ohkohchi, Nobuhiro

“…Even with current promising antitumor antibodies, their antitumor effects on stroma‐rich solid cancers have been insufficient. We used mild hyperthermia with…”
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Triple modal treatment comprising with proton beam radiation, hyperthermia, and gemcitabine/nab-paclitaxel for locally advanced pancreatic cancer: a phase I/II study protocol (TT-LAP trial) by Shimomura, Osamu, Endo, Masato, Makishima, Hirokazu, Yamada, Takeshi, Hashimoto, Shinji, Numajiri, Haruko, Miyazaki, Yoshihiro, Doi, Manami, Furuya, Kinji, Takahashi, Kazuhiro, Moriwaki, Toshikazu, Hasegawa, Naoyuki, Yamamoto, Yoshiyuki, Niisato, Yusuke, Kobayashi, Mariko, Mizumoto, Masashi, Nakai, Kei, Saito, Takashi, Hoshiai, Sodai, Saida, Tsukasa, Mathis, Bryan J, Mori, Kensaku, Nakajima, Takahito, Tsuchiya, Kiichiro, Sakurai, Hideyuki, Oda, Tatsuya

“…Locally advanced pancreatic ductal adenocarcinoma (PDAC), accounting for about 30% of PDAC patients, is difficult to cure by radical resection or systemic…”
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Primary pleomorphic liposarcoma of the liver: a case report and literature review by Terunuma, Yuri, Takahashi, Kazuhiro, Doi, Manami, Shimomura, Osamu, Miyazaki, Yoshihiro, Furuya, Kinji, Moue, Shoko, Owada, Yohei, Ogawa, Koichi, Ohara, Yusuke, Akashi, Yoshimasa, Hashimoto, Shinji, Enomoto, Tsuyoshi, Oda, Tatsuya

“…Background Primary liposarcoma arising from the liver is exceedingly rare. There have been very few reports documenting primary hepatic liposarcoma, especially…”
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