Search Results - "Osako, Yoichi"

Potential new therapy of Rapalink‐1, a new generation mammalian target of rapamycin inhibitor, against sunitinib‐resistant renal cell carcinoma by Kuroshima, Kazuki, Yoshino, Hirofumi, Okamura, Shunsuke, Tsuruda, Masafumi, Osako, Yoichi, Sakaguchi, Takashi, Sugita, Satoshi, Tatarano, Shuichi, Nakagawa, Masayuki, Enokida, Hideki

“…Sunitinib, a multitargeted receptor tyrosine kinase inhibitor including vascular endothelial growth factor, has been widely used as a first‐line treatment…”
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Potential tumor‑suppressive role of microRNA‑99a‑3p in sunitinib‑resistant renal cell carcinoma cells through the regulation of RRM2 by Osako, Yoichi, Yoshino, Hirofumi, Sakaguchi, Takashi, Sugita, Satoshi, Yonemori, Masaya, Nakagawa, Masayuki, Enokida, Hideki

“…Sunitinib is the most common primary molecular-targeted agent for metastatic clear cell renal cell carcinoma (ccRCC); however, intrinsic or acquired sunitinib…”
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Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant by Tsuruda, Masafumi, Yoshino, Hirofumi, Okamura, Shunsuke, Kuroshima, Kazuki, Osako, Yoichi, Sakaguchi, Takashi, Sugita, Satoshi, Tatarano, Shuichi, Nakagawa, Masayuki, Enokida, Hideki

“…Exosomes are 40-100 nm nano-sized extracellular vesicles. They are released from many cell types and move into the extracellular space, thereby transferring…”
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Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma by Yoshino, Hirofumi, Yamada, Yasutoshi, Enokida, Hideki, Osako, Yoichi, Tsuruda, Masafumi, Kuroshima, Kazuki, Sakaguchi, Takashi, Sugita, Satoshi, Tatarano, Shuichi, Nakagawa, Masayuki

“…The alcohol-abuse drug disulfiram has antitumor effects against diverse cancer types via inhibition of the ubiquitin-proteasome protein nuclear protein…”
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Targeting of the glutamine transporter SLC1A5 induces cellular senescence in clear cell renal cell carcinoma by Kawakami, Issei, Yoshino, Hirofumi, Fukumoto, Wataru, Tamai, Motoki, Okamura, Shunsuke, Osako, Yoichi, Sakaguchi, Takashi, Inoguchi, Satoru, Matsushita, Ryosuke, Yamada, Yasutoshi, Tatarano, Shuichi, Nakagawa, Masayuki, Enokida, Hideki

“…In recent years, cancer metabolism has attracted attention as a therapeutic target, and glutamine metabolism is considered one of the most important metabolic…”
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Acquired smooth muscle hamartoma of the scrotum by Kawahira, Hisao, Fujii, Kazuyasu, Yonezawa, Tomokazu, Osako, Yoichi, Kanekura, Takuro

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HRAS as a potential therapeutic target of salirasib RAS inhibitor in bladder cancer by Sugita, Satoshi, Enokida, Hideki, Yoshino, Hirofumi, Miyamoto, Kazutaka, Yonemori, Masaya, Sakaguchi, Takashi, Osako, Yoichi, Nakagawa, Masayuki

“…The active form of the small GTPase RAS binds to downstream effectors to promote cell growth and proliferation. RAS signal enhancement contributes to…”
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Low dose tacrolimus exposure and early steroid withdrawal with strict body weight control can improve post kidney transplant glucose tolerance in Japanese patients by Mitsuke, Akihiko, Ohbo, Takahiko, Arima, Junya, Osako, Yoichi, Sakaguchi, Takashi, Matsushita, Ryosuke, Yoshino, Hirofumi, Tatarano, Shuichi, Yamada, Yasutoshi, Sasaki, Hajime, Tanabe, Tatsu, Fukuzawa, Nobuyuki, Tanaka, Hiroshi, Nishio, Yoshihiko, Hideki, Enokida, Harada, Hiroshi

“…The development of diabetes mellitus (DM) after living donor kidney transplantation (KT) is a risk factor for worsening transplant kidney function, cardiac…”
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EHHADH contributes to cisplatin resistance through regulation by tumor-suppressive microRNAs in bladder cancer by Okamura, Shunsuke, Yoshino, Hirofumi, Kuroshima, Kazuki, Tsuruda, Masafumi, Osako, Yoichi, Sakaguchi, Takashi, Yonemori, Masaya, Yamada, Yasutoshi, Tatarano, Shuichi, Nakagawa, Masayuki, Enokida, Hideki

“…Cisplatin-based chemotherapy is recommended as the primary treatment for advanced bladder cancer (BC) with unresectable or metastatic disease. However, the…”
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Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation by Yoshino, Hirofumi, Enokida, Hideki, Osako, Yoichi, Nohata, Nijiro, Yonemori, Masaya, Sugita, Satoshi, Kuroshima, Kazuki, Tsuruda, Masafumi, Tatarano, Shuichi, Nakagawa, Masayuki

“…d‐3‐Phosphoglycerate dehydrogenase (PHGDH) conducts an important step in the synthesis of serine. Importantly, the PHGDH gene is often amplified in certain…”
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microRNA‐99a‐5p induces cellular senescence in gemcitabine‐resistant bladder cancer by targeting SMARCD1 by Tamai, Motoki, Tatarano, Shuichi, Okamura, Shunsuke, Fukumoto, Wataru, Kawakami, Issei, Osako, Yoichi, Sakaguchi, Takashi, Sugita, Satoshi, Yonemori, Masaya, Yamada, Yasutoshi, Nakagawa, Masayuki, Enokida, Hideki, Yoshino, Hirofumi

“…Patients with advanced bladder cancer are generally treated with a combination of chemotherapeutics, including gemcitabine, but the effect is limited due to…”
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Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma by Sakaguchi, Takashi, Yoshino, Hirofumi, Sugita, Satoshi, Miyamoto, Kazutaka, Yonemori, Masaya, Osako, Yoichi, Meguro-Horike, Makiko, Horike, Shin-Ichi, Nakagawa, Masayuki, Enokida, Hideki

“…Sunitinib is a standard molecular-targeted drug used as a first-line treatment for metastatic clear cell renal cell carcinoma (ccRCC); however, resistance to…”
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Assessing antiviral treatment efficacy and risk factors for severe COVID-19 in kidney transplant recipients during the Omicron subvariant-dominant period: a retrospective study by Sakaguchi, Takashi, Mitsuke, Akihiko, Osako, Yoichi, Yamada, Yasutoshi, Takeyama, Himawari, Ogawa, Risako, Takahashi, Katsuya, Hirohata, Yukiko, Yamamoto, Sayuri, Arima, Junya, Fukumoto, Wataru, Sugita, Satoshi, Inoguchi, Satoru, Matsushita, Ryosuke, Yoshino, Hirofumi, Tatarano, Shuichi, Enokida, Hideki

“…Kidney transplant recipients (KTRs) are at risk of severe coronavirus disease 2019 (COVID-19), and even now that Omicron subvariants have become dominant,…”
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Successful complete resection and recurrence-free outcome in renal cell carcinoma with vena cava tumor thrombus: Neoadjuvant immune checkpoint inhibitor (ICI)-based combination therapies by Yoshino, Hirofumi, Mitsuke, Akihiko, Osako, Yoichi, Sakaguchi, Takashi, Matsushita, Ryosuke, Inoguchi, Satoru, Tatarano, Shuichi, Yamada, Yasutoshi, Enokida, Hideki

“…Treatment of advanced renal cell carcinoma (RCC) typically involves surgery, even in challenging cases (ie, inferior vena cava [IVC] tumor thrombus, stage 3b…”
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Characterization and treatment of gemcitabine‐ and cisplatin‐resistant bladder cancer cells with a pan‐RAS inhibitor by Yoshino, Hirofumi, Yokoyama, Seiya, Tamai, Motoki, Okamura, Shunsuke, Iizasa, Sayaka, Sakaguchi, Takashi, Osako, Yoichi, Inoguchi, Satoru, Matsushita, Ryosuke, Yamada, Yasutoshi, Nakagawa, Masayuki, Tatarano, Shuichi, Tanimoto, Akihide, Enokida, Hideki

“…Combination chemotherapy with gemcitabine and cisplatin (GC) is recommended as the primary treatment for advanced bladder cancer (BC). However, the benefits of…”
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Acne vulgaris with false‐positive signals on 18F‐fluorodeoxyglucose positron emission tomography‐computed tomography in a patient with a yolk sac tumor by Okubo, Aoi, Fujii, Kazuyasu, Tada, Ko‐ichi, Higashi, Yuko, Hirohata, Yukiko, Osako, Yoichi, Eura, Rumiko, Yoshino, Hirofumi, Nakagawa, Masayuki, Kanekura, Takuro

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Unusual presentation of intraparenchymal renal artery aneurysm mimicking cystic renal cell carcinoma: A case report by Osako, Yoichi, Tatarano, Shuichi, Nishiyama, Kenryu, Yamada, Yasutoshi, Yamagata, Takaaki, Uchida, Yosuke, Nakagawa, Masayuki

“…We describe a case of intraparenchymal renal artery aneurysm in a 58‐year‐old normotensive man with a history of distal ureterectomy. Imaging studies of the…”
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MP18-16 POTENTIAL NEW THERAPY AGAINST SUNITINIB-RESISTANT RENAL CELL CARCINOMA by Kuroshima, Kazuki, Yoshino, Hirofumi, Okamura, Shunsuke, Tsuruda, Masafumi, Osako, Yoichi, Tatarano, Shuichi, Enokida, Hideki, Nakagawa, Masayuki

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MP18-12 ONCOGENIC EFFECTS THROUGH EXOSOME INDEPENDENT FUNCTION OF RAB27B IN RENAL CELL CARCINOMA INCLUDING SUNITINIB-RESISTANT by Yoshino, Hirofumi, Tsuruda, Masafumi, Okamura, Shunsuke, Kuroshima, Kazuki, Osako, Yoichi, Tatarano, Shuichi, Enokida, Hideki, Nakagawa, Masayuki

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PD64-05 THE UBIQUITIN-PROTEASOME PATHWAY VIA NPL4 SUPPRESSION IS A PROMISING THERAPEUTIC TARGET IN CLEAR CELL RENAL CELL CARCINOMA by Yoshino, Hirofumi, Osako, Yoichi, Yonemori, Masaya, Tsuruta, Masafumi, Kuroshima, Kazuki, Enokida, Hideki, Nakagawa, Masayuki

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