Search Results - "Osafune, Kenji"

Regenerative treatments for kidney diseases: The closest and fastest strategies to solving related medical and economic problems by Osafune, Kenji

“…Recent advances in developmental biology and stem cell biology have led to the increased availability of extrarenal stem cells, including mesenchymal/stromal…”
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Current status and future directions of clinical applications using iPS cells—focus on Japan by Tsujimoto, Hiraku, Osafune, Kenji

“…Regenerative medicine using iPS cell technologies has progressed remarkably in recent years. In this review, we summarize these technologies and their clinical…”
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iPSC technology-based regenerative medicine for kidney diseases by Osafune, Kenji

“…With few curative treatments for kidney diseases, increasing attention has been paid to regenerative medicine as a new therapeutic option. Recent progress in…”
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Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation by Takebe, Takanori, Enomura, Masahiro, Yoshizawa, Emi, Kimura, Masaki, Koike, Hiroyuki, Ueno, Yasuharu, Matsuzaki, Takahisa, Yamazaki, Takashi, Toyohara, Takafumi, Osafune, Kenji, Nakauchi, Hiromitsu, Yoshikawa, Hiroshi Y., Taniguchi, Hideki

“…Transplantation of in-vitro-generated organ buds is a promising approach toward regenerating functional and vascularized organs. Though it has been recently…”
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PKD1 -Dependent Renal Cystogenesis in Human Induced Pluripotent Stem Cell-Derived Ureteric Bud/Collecting Duct Organoids by Kuraoka, Shohei, Tanigawa, Shunsuke, Taguchi, Atsuhiro, Hotta, Akitsu, Nakazato, Hitoshi, Osafune, Kenji, Kobayashi, Akio, Nishinakamura, Ryuichi

“…Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease leading to renal failure, wherein multiple cysts form in…”
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Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation by Ohnishi, Kotaro, Semi, Katsunori, Yamamoto, Takuya, Shimizu, Masahito, Tanaka, Akito, Mitsunaga, Kanae, Okita, Keisuke, Osafune, Kenji, Arioka, Yuko, Maeda, Toshiyuki, Soejima, Hidenobu, Moriwaki, Hisataka, Yamanaka, Shinya, Woltjen, Knut, Yamada, Yasuhiro

“…Cancer is believed to arise primarily through accumulation of genetic mutations. Although induced pluripotent stem cell (iPSC) generation does not require…”
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Kidney organoids: Research in developmental biology and emerging applications by Shimizu, Tatsuya, Yamagata, Kunihiro, Osafune, Kenji

“…Kidney organoids generated from human pluripotent stem cells (hPSCs) have drastically changed the field of stem cell research on human kidneys within a few…”
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Cell therapy for kidney injury: different options and mechanisms--kidney progenitor cells by Osafune, Kenji

“…Since no specific or radical treatments have yet been established for acute kidney injury (AKI), the development of cell transplantation therapy using renal…”
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Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm by Takahashi, Kazutoshi, Tanabe, Koji, Ohnuki, Mari, Narita, Megumi, Sasaki, Aki, Yamamoto, Masamichi, Nakamura, Michiko, Sutou, Kenta, Osafune, Kenji, Yamanaka, Shinya

“…During mammalian embryonic development, the primitive streak initiates the differentiation of pluripotent epiblast cells into germ layers. Pluripotency can be…”
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iPSC technology‐based regenerative therapy for diabetes by Kondo, Yasushi, Toyoda, Taro, Inagaki, Nobuya, Osafune, Kenji

“…The directed differentiation of human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), into pancreatic…”
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Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells by Gotoh, Shimpei, Ito, Isao, Nagasaki, Tadao, Yamamoto, Yuki, Konishi, Satoshi, Korogi, Yohei, Matsumoto, Hisako, Muro, Shigeo, Hirai, Toyohiro, Funato, Michinori, Mae, Shin-Ichi, Toyoda, Taro, Sato-Otsubo, Aiko, Ogawa, Seishi, Osafune, Kenji, Mishima, Michiaki

“…No methods for isolating induced alveolar epithelial progenitor cells (AEPCs) from human embryonic stem cells (hESCs) and induced pluripotent stem cells…”
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Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential by Mae, Shin-Ichi, Ryosaka, Makoto, Sakamoto, Satoko, Matsuse, Kyoko, Nozaki, Aya, Igami, Maiko, Kabai, Ryotaro, Watanabe, Akira, Osafune, Kenji

“…Ureteric bud (UB) is the embryonic kidney progenitor tissue that gives rise to the collecting duct and lower urinary tract. UB-like structures generated from…”
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Generation of branching ureteric bud tissues from human pluripotent stem cells by Mae, Shin-Ichi, Ryosaka, Makoto, Toyoda, Taro, Matsuse, Kyoko, Oshima, Yoichi, Tsujimoto, Hiraku, Okumura, Shiori, Shibasaki, Aya, Osafune, Kenji

“…Recent progress in kidney regeneration research is noteworthy. However, the selective and robust differentiation of the ureteric bud (UB), an embryonic renal…”
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Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches by Miki, Kenji, Endo, Kei, Takahashi, Seiya, Funakoshi, Shunsuke, Takei, Ikue, Katayama, Shota, Toyoda, Taro, Kotaka, Maki, Takaki, Tadashi, Umeda, Masayuki, Okubo, Chikako, Nishikawa, Misato, Oishi, Akiko, Narita, Megumi, Miyashita, Ito, Asano, Kanako, Hayashi, Karin, Osafune, Kenji, Yamanaka, Shinya, Saito, Hirohide, Yoshida, Yoshinori

“…Isolation of specific cell types, including pluripotent stem cell (PSC)-derived populations, is frequently accomplished using cell surface antigens expressed…”
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Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods by Araoka, Toshikazu, Mae, Shin-ichi, Kurose, Yuko, Uesugi, Motonari, Ohta, Akira, Yamanaka, Shinya, Osafune, Kenji

“…The first step in developing regenerative medicine approaches to treat renal diseases using pluripotent stem cells must be the generation of intermediate…”
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Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells by Mae, Shin-Ichi, Shono, Akemi, Shiota, Fumihiko, Yasuno, Tetsuhiko, Kajiwara, Masatoshi, Gotoda-Nishimura, Nanaka, Arai, Sayaka, Sato-Otubo, Aiko, Toyoda, Taro, Takahashi, Kazutoshi, Nakayama, Naoki, Cowan, Chad A., Aoi, Takashi, Ogawa, Seishi, McMahon, Andrew P., Yamanaka, Shinya, Osafune, Kenji

“…A method for stimulating the differentiation of human pluripotent stem cells into kidney lineages remains to be developed. Most cells in kidney are derived…”
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Small molecule TCS21311 can replace BMP7 and facilitate cell proliferation in in vitro expansion culture of nephron progenitor cells by Tsujimoto, Hiraku, Araoka, Toshikazu, Nishi, Yohei, Ohta, Akira, Nakahata, Tatsutoshi, Osafune, Kenji

“…Several groups have developed in vitro expansion cultures for mouse metanephric nephron progenitor cells (NPCs) using cocktails of small molecules and growth…”
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Podocytes are lost from glomeruli before completing apoptosis by Yamamoto, Kazuyoshi, Okabe, Masahiro, Tanaka, Keiko, Yokoo, Takashi, Pastan, Ira, Araoka, Toshikazu, Osafune, Kenji, Udagawa, Tomohiro, Koizumi, Masahiro, Matsusaka, Taiji

“…Although apoptosis of podocytes has been widely reported in in vitro studies, it has been less frequently and less definitively documented in in vivo…”
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Cell Therapy Using Human Induced Pluripotent Stem Cell‐Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice by Toyohara, Takafumi, Mae, Shin-Ichi, Sueta, Shin-Ichi, Inoue, Tatsuyuki, Yamagishi, Yukiko, Kawamoto, Tatsuya, Kasahara, Tomoko, Hoshina, Azusa, Toyoda, Taro, Tanaka, Hiromi, Araoka, Toshikazu, Sato-Otsubo, Aiko, Takahashi, Kazutoshi, Sato, Yasunori, Yamaji, Noboru, Ogawa, Seishi, Yamanaka, Shinya, Osafune, Kenji

“…A multistep differentiation protocol for inducing human induced pluripotent stem cells (hiPSCs) into OSR1+SIX2+ renal progenitors capable of reconstituting…”
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A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells by Tsujimoto, Hiraku, Kasahara, Tomoko, Sueta, Shin-ichi, Araoka, Toshikazu, Sakamoto, Satoko, Okada, Chihiro, Mae, Shin-ichi, Nakajima, Taiki, Okamoto, Natsumi, Taura, Daisuke, Nasu, Makoto, Shimizu, Tatsuya, Ryosaka, Makoto, Li, Zhongwei, Sone, Masakatsu, Ikeya, Makoto, Watanabe, Akira, Osafune, Kenji

“…Recent studies using human pluripotent stem cells (hPSCs) have developed protocols to induce kidney-lineage cells and reconstruct kidney organoids. However,…”
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