Effects of Oral Contraceptives on Coagulation Factors in African Women

Effects of Oral Contraceptives on Coagulation Factors in African Women

Despite overwhelming evidence that the use of oral contraceptive pills (OCP) may lead to thrombotic episodes, no studies have been performed to investigate the effect of OCP on the coagulation profile in African women. We assessed the levels of fibrinogen, factors VIIc, and VIIIc as well as the fibr...

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Bibliographic Details
Published in:Thrombosis research Vol. 90; no. 1; pp. 27 - 30
Main Authors: Famodu, A.A, Osadebe, W.C
Format: Journal Article
Language:English
Published: New York, NY Elsevier Ltd 01-04-1998
Elsevier Science
Subjects:
Adult
African woman
Biological and medical sciences
Blood Coagulation Factors - drug effects
Case-Control Studies
Contraceptives, Oral - adverse effects
Drug toxicity and drugs side effects treatment
Factor VIIc, VIIIc
Female
Fibrinogen
Humans
Medical sciences
Nigeria
Oral contraceptives
Pharmacology. Drug treatments
Risk Factors
Thrombosis - chemically induced
Toxicity: cardiovascular system
Nigeria
Africa
African woman
Factor VIIc, VIIIc
Oral contraceptives
OCP, oral contraceptive pills
Fibrinogen
OCT, oral contraceptive therapy
Vascular disease
Ethinylestradiol
Human
Hemostasis
Toxicity
Risk factor
Oral administration
Cardiovascular disease
Female
Contraceptive
Coagulation factor
Thrombosis
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Summary:Despite overwhelming evidence that the use of oral contraceptive pills (OCP) may lead to thrombotic episodes, no studies have been performed to investigate the effect of OCP on the coagulation profile in African women. We assessed the levels of fibrinogen, factors VIIc, and VIIIc as well as the fibrinolytic activity in 100 African women on OCP. Fibrinogen levels were significantly increased ( p<0.001) and factors VIIc, VIIIc, and fibrinolytic activity significantly decreased ( p<0.001) when compared with those of healthy women not on OCP. We conclude that the combination of hyperfibrinogenaemia and decreased fibrinolytic activity combined with a decrease in factor VIIc and VIIIc levels reflects a hemostatic imbalance in African women on OCP that needs to be investigated.
ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(98)00004-8