Search Results - "Orzechowski, Marek"

Structure and flexibility of the tropomyosin overlap junction by Li, Xiaochuan Edward, Orzechowski, Marek, Lehman, William, Fischer, Stefan

“…•Head-to-tail linkage is required for tropomyosin cable formation on F-actin.•Molecular dynamics of tropomyosin overlap domains were carried out.•N- to…”
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An Atomic Model of the Tropomyosin Cable on F-actin by Orzechowski, Marek, Li, Xiaochuan (Edward), Fischer, Stefan, Lehman, William

“…Tropomyosin regulates a wide variety of actin filament functions and is best known for the role that it plays together with troponin in controlling muscle…”
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Energy landscapes reveal the myopathic effects of tropomyosin mutations by Orzechowski, Marek, Fischer, Stefan, Moore, Jeffrey R., Lehman, William, Farman, Gerrie P.

“…[Display omitted] •Interaction energies between mutant tropomyosins and actin were calculated.•Missense mutations reset the switching mechanism controlling…”
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Three-Dimensional Organization of Troponin on Cardiac Muscle Thin Filaments in the Relaxed State by Yang, Shixin, Barbu-Tudoran, Lucian, Orzechowski, Marek, Craig, Roger, Trinick, John, White, Howard, Lehman, William

“…Muscle contraction is regulated by troponin-tropomyosin, which blocks and unblocks myosin binding sites on actin. To elucidate this regulatory mechanism, the…”
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High-Throughput Neutralization and Serology Assays Reveal Correlated but Highly Variable Humoral Immune Responses in a Large Population of Individuals Infected with SARS-CoV-2 in the US between March and August 2020 by Zhang, Shuting, Ma, Peijun, Orzechowski, Marek, Lemmer, Allison, Rzasa, Kara, Bagnall, Josephine, Barkho, Sulyman, Chen, Michael, He, Lorri, Neitupski, Raymond, Tran, Victoria, Ackerman, Ross, Gath, Emily, Bond, Austin, Frongillo, Giana, Cleland, Thomas, Golas, Aaron, Gaca, Anthony, Fitzgerald, Michael, Kelly, Kathleen, Hazegh, Kelsey, Dumont, Larry, Hoffman, Corey, Homer, Mary, Marks, Peter, Woolley, Ann, Wong, Sharon, Gomez, James, Livny, Jonathan, Hung, Deborah

“…The ability to measure neutralizing antibodies on large scale can be important for understanding features of the natural history and epidemiology of infection,…”
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Mechanical Unfolding of the Beet Western Yellow Virus −1 Frameshift Signal by White, Katherine H, Orzechowski, Marek, Fourmy, Dominique, Visscher, Koen

“…Using mechanical unfolding by optical tweezers (OT) and steered molecular dynamics (SMD) simulations, we have demonstrated the critical role of Mg2+ ions for…”
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Flexible Fitting of High-Resolution X-Ray Structures into Cryoelectron Microscopy Maps Using Biased Molecular Dynamics Simulations by Orzechowski, Marek, Tama, Florence

“…A methodology for flexible fitting of all-atom high-resolution structures into low-resolution cryoelectron microscopy (cryo-EM) maps is presented. Flexibility…”
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A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles by Subramanian, Aravind, Narayan, Rajiv, Corsello, Steven M., Peck, David D., Natoli, Ted E., Lu, Xiaodong, Gould, Joshua, Davis, John F., Tubelli, Andrew A., Asiedu, Jacob K., Lahr, David L., Hirschman, Jodi E., Liu, Zihan, Donahue, Melanie, Julian, Bina, Khan, Mariya, Wadden, David, Smith, Ian C., Lam, Daniel, Liberzon, Arthur, Toder, Courtney, Bagul, Mukta, Orzechowski, Marek, Enache, Oana M., Piccioni, Federica, Johnson, Sarah A., Lyons, Nicholas J., Berger, Alice H., Shamji, Alykhan F., Brooks, Angela N., Vrcic, Anita, Flynn, Corey, Rosains, Jacqueline, Takeda, David Y., Hu, Roger, Davison, Desiree, Lamb, Justin, Ardlie, Kristin, Hogstrom, Larson, Greenside, Peyton, Gray, Nathanael S., Clemons, Paul A., Silver, Serena, Wu, Xiaoyun, Zhao, Wen-Ning, Read-Button, Willis, Wu, Xiaohua, Haggarty, Stephen J., Ronco, Lucienne V., Boehm, Jesse S., Schreiber, Stuart L., Doench, John G., Bittker, Joshua A., Root, David E., Wong, Bang, Golub, Todd R.

“…We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression…”
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Dynamics of Water Filaments in Disordered Environments by Orzechowski, Marek, Meuwly, Markus

“…The formation, stability, and dynamics of water filaments in disordered environments is investigated by using atomistic molecular dynamics simulations. It is…”
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Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics by Romano, Keith P, Bagnall, Josephine, Warrier, Thulasi, Sullivan, Jaryd, Ferrara, Kristina, Orzechowski, Marek, Nguyen, Phuong H, Raines, Kyra, Livny, Jonathan, Shoresh, Noam, Hung, Deborah T

“…The rising prevalence of antibiotic resistance threatens human health. While more sophisticated strategies for antibiotic discovery are being developed, target…”
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SARS‐CoV‐2 antibody persistence in COVID‐19 convalescent plasma donors: Dependency on assay format and applicability to serosurveillance by Di Germanio, Clara, Simmons, Graham, Kelly, Kathleen, Martinelli, Rachel, Darst, Orsolya, Azimpouran, Mahzad, Stone, Mars, Hazegh, Kelsey, Grebe, Eduard, Zhang, Shuting, Ma, Peijun, Orzechowski, Marek, Gomez, James E., Livny, Jonathan, Hung, Deborah T., Vassallo, Ralph, Busch, Michael P., Dumont, Larry J.

“…Background Antibody response duration following severe acute respiratory syndrome coronavirus 2 infection tends to be variable and depends on severity of…”
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HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments by Farman, Gerrie P., Rynkiewicz, Michael J., Orzechowski, Marek, Lehman, William, Moore, Jeffrey R.

“…Calcium regulation of cardiac muscle contraction is controlled by the thin-filament proteins troponin and tropomyosin bound to actin. In the absence of…”
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Does Tropomyosin Slide or Roll over F-Actin during Regulatory Transitions? by Rynkiewicz, Michael, Schott, Veronika, Orzechowski, Marek, Fischer, Stefan, Lehman, William

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Tropomyosin movement on F-actin during muscle activation explained by energy landscapes by Orzechowski, Marek, Moore, Jeffrey R., Fischer, Stefan, Lehman, William

“…•An energy landscape was calculated for tropomyosin on the surface of F-actin.•The energy minimum locates tropomyosin near its myosin-blocking position on…”
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Gestalt-Binding of tropomyosin on actin during thin filament activation by Lehman, William, Orzechowski, Marek, Li, Xiaochuan Edward, Fischer, Stefan, Raunser, Stefan

“…Our thesis is that thin filament function can only be fully understood and muscle regulation then elucidated if atomic structures of the thin filament are…”
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The structural dynamics of α-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules by Lehman, William, Li, Xiaochuan (Edward), Orzechowski, Marek, Fischer, Stefan

“…[Display omitted] •Molecular Dynamics simulations describe tropomyosin binding on actin.•During MD, tropomyosin largely matches a canonical coiled-coil model…”
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Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin by Rynkiewicz, Michael J., Schott, Veronika, Orzechowski, Marek, Lehman, William, Fischer, Stefan

“…Azimuthal movement of tropomyosin around the F-actin thin filament is responsible for muscle activation and relaxation. Recently a model of αα-tropomyosin,…”
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The Actc A295S Hypertrophic Cardiomyopathy Mutation Promotes Thin Filament Disinhibition and Enhances Contractile Activity by Viswanathan, Meera C., Schmidt, William, Orzechowski, Marek, Lehman, William, Cammarato, Anthony

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Influence of Actin Mutation on the Energy Landscape of Actin-Tropomyosin Filaments by Orzechowski, Marek, Fischer, Stefan, Lehman, William

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Large-Scale Chemical-Genetic Strategy Enables the Design of Antimicrobial Combination Chemotherapy in Mycobacteria by Johnson, Eachan O, Office, Emma, Kawate, Tomohiko, Orzechowski, Marek, Hung, Deborah T

“…The efficacies of all antibiotics against tuberculosis are eventually eroded by resistance. New strategies to discover drugs or drug combinations with higher…”
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