Search Results - "Orzáez, Mar"

Understanding MCL1: from cellular function and regulation to pharmacological inhibition by Sancho, Mónica, Leiva, Diego, Lucendo, Estefanía, Orzáez, Mar

“…Myeloid cell leukemia‐1 (MCL1), an antiapoptotic member of the BCL2 family characterized by a short half‐life, functions as a rapid sensor that regulates cell…”
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The past, present, and future of breast cancer models for nanomedicine development by Boix-Montesinos, Paz, Soriano-Teruel, Paula M., Armiñán, Ana, Orzáez, Mar, Vicent, María J.

“…[Display omitted] Even given recent advances in nanomedicine development of breast cancer treatment in recent years and promising results in pre-clinical…”
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Split-luciferase complementary assay of NLRP3 PYD-PYD interaction indicates inflammasome formation during inflammation by Isazadeh, Mohsen, Amandadi, Mojdeh, Haghdoust, Farnaz, Lotfollazadeh, Shima, Orzáez, Mar, Hosseinkhani, Saman

“…The NLRP3 inflammasome is a key macromolecular complex of the innate immune system that activates the inflammatory signalling cascade in response to a wide…”
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Real‐Time In Vivo Detection of Cellular Senescence through the Controlled Release of the NIR Fluorescent Dye Nile Blue by Lozano‐Torres, Beatriz, Blandez, Juan F., Galiana, Irene, García‐Fernández, Alba, Alfonso, María, Marcos, María D., Orzáez, Mar, Sancenón, Félix, Martínez‐Máñez, Ramón

“…In vivo detection of cellular senescence is accomplished by using mesoporous silica nanoparticles loaded with the NIR‐FDA approved Nile blue (NB) dye and…”
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Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases by Soriano-Teruel, Paula M., García‑Laínez, Guillermo, Marco-Salvador, María, Pardo, Julián, Arias, Maykel, DeFord, Christian, Merfort, Irmgard, Vicent, María J., Pelegrín, Pablo, Sancho, Mónica, Orzáez, Mar

“…The ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD)) protein is an scaffold component of different inflammasomes,…”
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Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition by Elena-Real, Carlos A., Díaz-Quintana, Antonio, González-Arzola, Katiuska, Velázquez-Campoy, Adrián, Orzáez, Mar, López-Rivas, Abelardo, Gil-Caballero, Sergio, De la Rosa, Miguel Á., Díaz-Moreno, Irene

“…Apoptosis is a highly regulated form of programmed cell death, essential to the development and homeostasis of multicellular organisms. Cytochrome c is a…”
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Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic by Galiana, Irene, Lozano-Torres, Beatriz, Sancho, Mónica, Alfonso, María, Bernardos, Andrea, Bisbal, Viviana, Serrano, Manuel, Martínez-Máñez, Ramón, Orzáez, Mar

“…The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete immune cell-mediated…”
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Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice by Lérida-Viso, Araceli, Estepa- Fernández, Alejandra, Morellá-Aucejo, Ángela, Lozano-Torres, Beatriz, Alfonso, María, Blandez, Juan F., Bisbal, Viviana, Sepúlveda, Pilar, García-Fernández, Alba, Orzáez, Mar, Martínez-Máñez, Ramón

“…Many anticancer agents used in clinics induce premature senescence in healthy tissues generating accelerated aging processes and adverse side-effects in…”
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The chemistry of senescence by Lozano-Torres, Beatriz, Estepa-Fernández, Alejandra, Rovira, Miguel, Orzáez, Mar, Serrano, Manuel, Martínez-Máñez, Ramón, Sancenón, Félix

“…Senescence is a state of permanent cell cycle arrest. Cellular senescence can promote tissue remodelling but can negatively affect regenerative capacities of…”
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Targeted-lung delivery of dexamethasone using gated mesoporous silica nanoparticles. A new therapeutic approach for acute lung injury treatment by García-Fernández, Alba, Sancho, Mónica, Bisbal, Viviana, Amorós, Pedro, Marcos, María D., Orzáez, Mar, Sancenón, Félix, Martínez-Máñez, Ramón

“…Acute lung injury (ALI) is a critical inflammatory syndrome, characterized by increased diffuse inflammation and severe lung damage, which represents a…”
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Gold Nanostars Coated with Mesoporous Silica Are Effective and Nontoxic Photothermal Agents Capable of Gate Keeping and Laser-Induced Drug Release by Hernández Montoto, Andy, Montes, Roberto, Samadi, Akbar, Gorbe, Mónica, Terrés, José Manuel, Cao-Milán, Roberto, Aznar, Elena, Ibañez, Javier, Masot, Rafael, Marcos, María Dolores, Orzáez, Mar, Sancenón, Félix, Oddershede, Lene B, Martínez-Máñez, Ramón

“…Herein, a novel drug photorelease system based on gold nanostars (AuNSts), coated with a mesoporous silica shell and capped with paraffin as thermosensitive…”
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MUC1 Aptamer‐Capped Mesoporous Silica Nanoparticles for Navitoclax Resistance Overcoming in Triple‐Negative Breast Cancer by Vivo‐Llorca, Gema, Candela‐Noguera, Vicente, Alfonso, María, García‐Fernández, Alba, Orzáez, Mar, Sancenón, Félix, Martínez‐Máñez, Ramón

“…Triple‐negative breast cancer (TNBC) is the most aggressive breast cancer subtype. In the last years, navitoclax has emerged as a possible treatment for TNBC…”
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A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis by Rojas-Vázquez, Sara, Lozano-Torres, Beatriz, García-Fernández, Alba, Galiana, Irene, Perez-Villalba, Ana, Martí-Rodrigo, Pablo, Palop, M. José, Domínguez, Marcia, Orzáez, Mar, Sancenón, Félix, Blandez, Juan F., Fariñas, Isabel, Martínez-Máñez, Ramón

“…Accumulation of senescent cells with age leads to tissue dysfunction and related diseases. Their detection in vivo still constitutes a challenge in aging…”
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Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis by Lucendo, Estefanía, Sancho, Mónica, Lolicato, Fabio, Javanainen, Matti, Kulig, Waldemar, Leiva, Diego, Duart, Gerard, Andreu-Fernández, Vicente, Mingarro, Ismael, Orzáez, Mar

“…The Bcl-2 protein family comprises both pro- and antiapoptotic members that control the permeabilization of the mitochondrial outer membrane, a crucial step in…”
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Janus Gold Nanostars–Mesoporous Silica Nanoparticles for NIR‐Light‐Triggered Drug Delivery by Hernández Montoto, Andy, Llopis‐Lorente, Antoni, Gorbe, Mónica, M. Terrés, José, Cao‐Milán, Roberto, Díaz de Greñu, Borja, Alfonso, María, Ibañez, Javier, Marcos, María D., Orzáez, Mar, Villalonga, Reynaldo, Martínez‐Máñez, Ramón, Sancenón, Félix

“…Janus gold nanostar–mesoporous silica nanoparticle (AuNSt–MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR)…”
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Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes by Andreu-Fernández, Vicente, Sancho, Mónica, Genovés, Ainhoa, Lucendo, Estefanía, Todt, Franziska, Lauterwasser, Joachim, Funk, Kathrin, Jahreis, Günther, Pérez-Payá, Enrique, Mingarro, Ismael, Edlich, Frank, Orzáez, Mar

“…The Bcl-2 (B-cell lymphoma 2) protein Bax (Bcl-2 associated X, apoptosis regulator) can commit cells to apoptosis via outer mitochondrial membrane…”
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Identification of NLRP3PYD Homo-Oligomerization Inhibitors with Anti-Inflammatory Activity by Moasses Ghafary, Soroush, Soriano-Teruel, Paula M., Lotfollahzadeh, Shima, Sancho, Mónica, Serrano-Candelas, Eva, Karami, Fatemeh, Barigye, Stephen J., Fernández-Pérez, Iván, Gozalbes, Rafael, Nikkhah, Maryam, Orzáez, Mar, Hosseinkhani, Saman

“…Inflammasomes are multiprotein complexes that represent critical elements of the inflammatory response. The dysregulation of the best-characterized complex,…”
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Horseradish Peroxidase-Functionalized Gold Nanoconjugates for Breast Cancer Treatment Based on Enzyme Prodrug Therapy by Vivo-Llorca, Gema, Morellá-Aucejo, Ángela, García-Fernández, Alba, Díez, Paula, Llopis-Lorente, Antoni, Orzáez, Mar, Martínez-Máñez, Ramón

“…Breast cancer has the highest mortality rate among cancers in women. Patients suffering from certain breast cancers, such as triple-negative breast cancer…”
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Temperature-controlled release by changes in the secondary structure of peptides anchored onto mesoporous silica supports by de la Torre, Cristina, Agostini, Alessandro, Mondragón, Laura, Orzáez, Mar, Sancenón, Félix, Martínez-Máñez, Ramón, Marcos, María D, Amorós, Pedro, Pérez-Payá, Enríque

“…Changes in the conformation of a peptide anchored onto the external surface of mesoporous silica nanoparticles have been used to design novel…”
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Hybrid Mesoporous Nanocarriers Act by Processing Logic Tasks: Toward the Design of Nanobots Capable of Reading Information from the Environment by Llopis-Lorente, Antoni, de Luis, Beatriz, García-Fernández, Alba, Jimenez-Falcao, Sandra, Orzáez, Mar, Sancenón, Félix, Villalonga, Reynaldo, Martínez-Máñez, Ramón

“…Here, we present the design of smart nanodevices capable of reading molecular information from the environment and acting accordingly by processing Boolean…”
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