Search Results - "Orum, Henrik"

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction by Kocerha, Jannet, Faghihi, Mohammad Ali, Lopez-Toledano, Miguel A, Huang, Jia, Ramsey, Amy J, Caron, Marc G, Sales, Nicole, Willoughby, David, Elmen, Joacim, Hansen, Henrik F, Orum, Henrik, Kauppinen, Sakari, Kenny, Paul J, Wahlestedt, Claes

“…N-methyl-D-aspartate (NMDA) glutamate receptors are regulators of fast neurotransmission and synaptic plasticity in the brain. Disruption of NMDA-mediated…”
Get full text

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection by Lanford, Robert E, Hildebrandt-Eriksen, Elisabeth S, Petri, Andreas, Persson, Robert, Lindow, Morten, Munk, Martin E, Kauppinen, Sakari, Ørum, Henrik

“…The liver-expressed microRNA-122 (miR-122) is essential for hepatitis C virus (HCV) RNA accumulation in cultured liver cells, but its potential as a target for…”
Get full text

MicroRNAs in Liver Disease by Wang, Xin Wei, Heegaard, Niels H.H, Ørum, Henrik

“…MicroRNAs are small noncoding RNA molecules that regulate gene expression posttranscriptionally through complementary base pairing with thousands of messenger…”
Get full text

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents by Stein, C.A, Hansen, J. Bo, Lai, Johnathan, Wu, SiJian, Voskresenskiy, Anatoliy, Høg, Anja, Worm, Jesper, Hedtjärn, Maj, Souleimanian, Naira, Miller, Paul, Soifer, Harris S, Castanotto, Daniella, Benimetskaya, Luba, Ørum, Henrik, Koch, Troels

“…For the past 15-20 years, the intracellular delivery and silencing activity of oligodeoxynucleotides have been essentially completely dependent on the use of a…”
Get full text

Antisense‐mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first‐in‐human randomized, placebo‐controlled trial by Poelgeest, Eveline P., Hodges, Michael R., Moerland, Matthijs, Tessier, Yann, Levin, Arthur A., Persson, Robert, Lindholm, Marie W., Dumong Erichsen, Kamille, Ørum, Henrik, Cohen, Adam F., Burggraaf, Jacobus

“…Aims LDL‐receptor expression is inhibited by the protease proprotein convertase subtilisin/kexin type 9 (PCSK9), which is considered a pharmacological target…”
Get full text

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo by Gupta, Nidhi, Fisker, Niels, Asselin, Marie-Claude, Lindholm, Marie, Rosenbohm, Christoph, Ørum, Henrik, Elmén, Joacim, Seidah, Nabil G, Straarup, Ellen Marie

“…The proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important factor in the etiology of familial hypercholesterolemia (FH) and is also an…”
Get full text

A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth by Greenberger, Lee M., Horak, Ivan D., Filpula, David, Sapra, Puja, Westergaard, Majken, Frydenlund, Henrik F., Albæk, Charlotte, Schrøder, Henrik, Ørum, Henrik

“…Abstract Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a critical role in angiogenesis, survival, metastasis, drug resistance, and…”
Get full text

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates by Straarup, Ellen Marie, Fisker, Niels, Hedtjärn, Maj, Lindholm, Marie W, Rosenbohm, Christoph, Aarup, Vibeke, Hansen, Henrik Frydenlund, Ørum, Henrik, Hansen, Jens B. Rode, Koch, Troels

“…The potency and specificity of locked nucleic acid (LNA) antisense oligonucleotides was investigated as a function of length and affinity. The oligonucleotides…”
Get full text

PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates by Lindholm, Marie W, Elmén, Joacim, Fisker, Niels, Hansen, Henrik F, Persson, Robert, Møller, Marianne R, Rosenbohm, Christoph, Ørum, Henrik, Straarup, Ellen M, Koch, Troels

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a therapeutic target for the reduction of low-density lipoprotein cholesterol (LDL-C)…”
Get full text

Locked nucleic acid holds promise in the treatment of cancer by Frieden, Miriam, Ørum, Henrik

“…Providing novel treatments to help cancer patients live longer and have better lives remains one of the biggest challenges of the pharmaceutical industry…”
Get more information

Efficient and Persistent Splice Switching by Systemically Delivered LNA Oligonucleotides in Mice by Roberts, Jennifer, Palma, Enzo, Sazani, Peter, Ørum, Henrik, Cho, Moo, Kole, Ryszard

“…Locked nucleic acid (LNA) oligomers were found to be very effective in their ability to modulate alternative splicing in vivo in transgenic mice that…”
Get full text

Electronic Structures of LNA Phosphorothioate Oligonucleotides by Bohr, Henrik G., Shim, Irene, Stein, Cy, Ørum, Henrik, Hansen, Henrik F., Koch, Troels

“…Important oligonucleotides in anti-sense research have been investigated in silico and experimentally. This involves quantum mechanical (QM) calculations and…”
Get full text

SPC3042: a proapoptotic survivin inhibitor by Hansen, Jens Bo, Fisker, Niels, Westergaard, Majken, Kjaerulff, Lene Sønderby, Hansen, Henrik Frydenlund, Thrue, Charlotte Albaek, Rosenbohm, Christoph, Wissenbach, Margit, Orum, Henrik, Koch, Troels

“…The ability to regulate the cellular homeostasis of a higher organism through tight control of apoptosis and cell division is crucial for life. Dysregulation…”
Get full text

Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern by Hagedorn, Peter H, Yakimov, Victor, Ottosen, Søren, Kammler, Susanne, Nielsen, Niels F, Høg, Anja M, Hedtjärn, Maj, Meldgaard, Michael, Møller, Marianne R, Orum, Henrik, Koch, Troels, Lindow, Morten

“…Antisense oligonucleotides that recruit RNase H and thereby cleave complementary messenger RNAs are being developed as therapeutics. Dose-dependent hepatic…”
Get more information

A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys by Hildebrandt-Eriksen, Elisabeth S, Aarup, Vibeke, Persson, Robert, Hansen, Henrik Frydenlund, Munk, Martin E, Ørum, Henrik

“…MicroRNA 122 (miR-122) is liver specific, fine-tunes lipid metabolism, and is required for hepatitis C virus (HCV) abundance. Miravirsen, an oligonucleotide…”
Get more information

Quantum mechanical studies of DNA and LNA by Koch, Troels, Shim, Irene, Lindow, Morten, Ørum, Henrik, Bohr, Henrik G

“…Quantum mechanical (QM) methodology has been employed to study the structure activity relations of DNA and locked nucleic acid (LNA). The QM calculations…”
Get more information

An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models by Graziewicz, Maria A, Tarrant, Teresa K, Buckley, Brian, Roberts, Jennifer, Fulton, LeShara, Hansen, Henrik, Ørum, Henrik, Kole, Ryszard, Sazani, Peter

“…Tumor necrosis factor-α (TNF-α) is a key mediator of inflammatory diseases, including rheumatoid arthritis (RA), and anti–TNF-α drugs such as etanercept are…”
Get full text

Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis by de Launay, Daphne, Vreijling, Jeroen, Hartkamp, Linda M, Karpus, Olga N, Abreu, Joana R.F, van Maanen, Marjolein A, Sanders, Marjolein E, Grabiec, Aleksander M, Hamann, Jörg, Ørum, Henrik, Vervoordeldonk, Margriet J, Fluiter, Kees, Tak, Paul P, Reedquist, Kris A

“…Changes in the expression and activation status of Ras proteins are thought to contribute to the pathological phenotype of stromal fibroblast-like synoviocytes…”
Get full text

Expanding the design horizon of antisense oligonucleotides with alpha‐l‐LNA by Frieden, Miriam, Christensen, Signe M., Mikkelsen, Nikolaj D., Rosenbohm, Christoph, Thrue, Charlotte A., Westergaard, Majken, Hansen, Henrik F., Ørum, Henrik, Koch, Troels

“…Oligonucleotides containing Locked Nucleic Acids (LNA) to various extents and at various positions were evaluated for antisense activity, RNase H recruitment,…”
Get full text

The application of locked nucleic acids in the treatment of cancer by Frieden, Miriam, Orum, Henrik

“…Locked nucleic acid (LNA) is a novel high-affinity and biologically stable RNA analog in which the normally flexible ribose sugar ring is fixed in a rigid…”
Get more information