Search Results - "Orton, Richard"

Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses by Shaw, Andrew E, Hughes, Joseph, Gu, Quan, Behdenna, Abdelkader, Singer, Joshua B, Dennis, Tristan, Orton, Richard J, Varela, Mariana, Gifford, Robert J, Wilson, Sam J, Palmarini, Massimo

“…The host innate immune response mediated by type I interferon (IFN) and the resulting up-regulation of hundreds of interferon-stimulated genes (ISGs) provide…”
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Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV) by Lefkowitz, Elliot J, Dempsey, Donald M, Hendrickson, Robert Curtis, Orton, Richard J, Siddell, Stuart G, Smith, Donald B

“…Abstract The International Committee on Taxonomy of Viruses (ICTV) is charged with the task of developing, refining, and maintaining a universal virus…”
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Predicting reservoir hosts and arthropod vectors from evolutionary signatures in RNA virus genomes by Babayan, Simon A, Orton, Richard J, Streicker, Daniel G

“…Identifying the animal origins of RNA viruses requires years of field and laboratory studies that stall responses to emerging infectious diseases. Using large…”
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In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2 by Szemiel, Agnieszka M, Merits, Andres, Orton, Richard J, MacLean, Oscar A, Pinto, Rute Maria, Wickenhagen, Arthur, Lieber, Gauthier, Turnbull, Matthew L, Wang, Sainan, Furnon, Wilhelm, Suarez, Nicolas M, Mair, Daniel, da Silva Filipe, Ana, Willett, Brian J, Wilson, Sam J, Patel, Arvind H, Thomson, Emma C, Palmarini, Massimo, Kohl, Alain, Stewart, Meredith E

“…Remdesivir (RDV), a broadly acting nucleoside analogue, is the only FDA approved small molecule antiviral for the treatment of COVID-19 patients. To date,…”
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Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination by Davis, Chris, Logan, Nicola, Tyson, Grace, Orton, Richard, Harvey, William T, Perkins, Jonathan S, Mollett, Guy, Blacow, Rachel M, Peacock, Thomas P, Barclay, Wendy S, Cherepanov, Peter, Palmarini, Massimo, Murcia, Pablo R, Patel, Arvind H, Robertson, David L, Haughney, John, Thomson, Emma C, Willett, Brian J

“…Vaccines are proving to be highly effective in controlling hospitalisation and deaths associated with SARS-CoV-2 infection but the emergence of viral variants…”
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Whole genome sequencing reveals local transmission patterns of Mycobacterium bovis in sympatric cattle and badger populations by Biek, Roman, O'Hare, Anthony, Wright, David, Mallon, Tom, McCormick, Carl, Orton, Richard J, McDowell, Stanley, Trewby, Hannah, Skuce, Robin A, Kao, Rowland R

“…Whole genome sequencing (WGS) technology holds great promise as a tool for the forensic epidemiology of bacterial pathogens. It is likely to be particularly…”
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Quantifying the roles of host movement and vector dispersal in the transmission of vector-borne diseases of livestock by Sumner, Tom, Orton, Richard J, Green, Darren M, Kao, Rowland R, Gubbins, Simon

“…The role of host movement in the spread of vector-borne diseases of livestock has been little studied. Here we develop a mathematical framework that allows us…”
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50 years of the International Committee on Taxonomy of Viruses: progress and prospects by Adams, Michael J., Lefkowitz, Elliot J., King, Andrew M. Q., Harrach, Balázs, Harrison, Robert L., Knowles, Nick J., Kropinski, Andrew M., Krupovic, Mart, Kuhn, Jens H., Mushegian, Arcady R., Nibert, Max L., Sabanadzovic, Sead, Sanfaçon, Hélène, Siddell, Stuart G., Simmonds, Peter, Varsani, Arvind, Zerbini, Francisco Murilo, Orton, Richard J., Smith, Donald B., Gorbalenya, Alexander E., Davison, Andrew J.

“…We mark the 50th anniversary of the International Committee on Taxonomy of Viruses (ICTV) by presenting a brief history of the organization since its…”
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Genetic diversity, infection prevalence, and possible transmission routes of Bartonella spp. in vampire bats by Becker, Daniel J, Bergner, Laura M, Bentz, Alexandra B, Orton, Richard J, Altizer, Sonia, Streicker, Daniel G

“…Bartonella spp. are globally distributed bacteria that cause endocarditis in humans and domestic animals. Recent work has suggested bats as zoonotic reservoirs…”
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Mutational signature dynamics indicate SARS-CoV-2's evolutionary capacity is driven by host antiviral molecules by Lamb, Kieran D, Luka, Martha M, Saathoff, Megan, Orton, Richard J, Phan, My V T, Cotten, Matthew, Yuan, Ke, Robertson, David L

“…The COVID-19 pandemic has been characterised by sequential variant-specific waves shaped by viral, individual human and population factors. SARS-CoV-2 variants…”
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Movement patterns in Florida pine snakes are shaped by landscape heterogeneity, ambient air temperature and reproductive ethology by Orton, Richard W, Wallrichs, Megan, Bankovich, Brittany, Bartolotti, Glenn, Hayman, Blair

“…Abstract Although variation in space use has been investigated extensively in terrestrial vertebrates, there have been recent criticisms that there are more…”
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Demographic and environmental drivers of metagenomic viral diversity in vampire bats by Bergner, Laura M., Orton, Richard J., Benavides, Julio A., Becker, Daniel J., Tello, Carlos, Biek, Roman, Streicker, Daniel G.

“…Viruses infect all forms of life and play critical roles as agents of disease, drivers of biochemical cycles and sources of genetic diversity for their hosts…”
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Resolving tradeoffs among crypsis, escape behavior, and microhabitat use in sexually dichromatic species by Orton, Richard W., McBrayer, Lance D.

“…Variation in color pattern between populations of cryptic animals is common and typically attributed to selection pressures from visual predators combined with…”
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Late Ebola virus relapse causing meningoencephalitis: a case report by Jacobs, Michael, Dr, Rodger, Alison, FRCP, Bell, David J, MRCP, Bhagani, Sanjay, FRCP, Cropley, Ian, FRCP, Filipe, Ana, PhD, Gifford, Robert J, PhD, Hopkins, Susan, FRCP, Hughes, Joseph, PhD, Jabeen, Farrah, FRCR, Johannessen, Ingolfur, FRCPath, Karageorgopoulos, Drosos, MRCP, Lackenby, Angie, PhD, Lester, Rebecca, MRCP, Liu, Rebecca S N, FRCP, MacConnachie, Alisdair, MRCP, Mahungu, Tabitha, MRCP, Martin, Daniel, FRCA, Marshall, Neal, MRPharmS, Mepham, Stephen, FRCPath, Orton, Richard, PhD, Palmarini, Massimo, Prof, Patel, Monika, MSc, Perry, Colin, FRCP, Peters, S Erica, MRCP, Porter, Duncan, MD, Ritchie, David, FRCR, Ritchie, Neil D, MRCP, Seaton, R Andrew, FRCP, Sreenu, Vattipally B, PhD, Templeton, Kate, FRCPath, Warren, Simon, FRCPath, Wilkie, Gavin S, PhD, Zambon, Maria, FRCPath, Gopal, Robin, PhD, Thomson, Emma C, FRCP

“…Summary Background There are thousands of survivors of the 2014 Ebola outbreak in west Africa. Ebola virus can persist in survivors for months in…”
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Characterizing and Evaluating the Zoonotic Potential of Novel Viruses Discovered in Vampire Bats by Bergner, Laura M, Mollentze, Nardus, Orton, Richard J, Tello, Carlos, Broos, Alice, Biek, Roman, Streicker, Daniel G

“…The contemporary surge in metagenomic sequencing has transformed knowledge of viral diversity in wildlife. However, evaluating which newly discovered viruses…”
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Population genomics of louping ill virus provide new insights into the evolution of tick-borne flaviviruses by Clark, Jordan J, Gilray, Janice, Orton, Richard J, Baird, Margaret, Wilkie, Gavin, Filipe, Ana da Silva, Johnson, Nicholas, McInnes, Colin J, Kohl, Alain, Biek, Roman, Powers, Ann M, Holbrook, Michael R

“…The emergence and spread of tick-borne arboviruses pose an increased challenge to human and animal health. In Europe this is demonstrated by the increasingly…”
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Detection of SARS‐CoV‐2 in respiratory samples from cats in the UK associated with human‐to‐cat transmission by Hosie, Margaret J., Epifano, Ilaria, Herder, Vanessa, Orton, Richard J., Stevenson, Andrew, Johnson, Natasha, MacDonald, Emma, Dunbar, Dawn, McDonald, Michael, Howie, Fiona, Tennant, Bryn, Herrity, Darcy, Da Silva Filipe, Ana, Streicker, Daniel G., Willett, Brian J., Murcia, Pablo R., Jarrett, Ruth F., Robertson, David L., Weir, William

“…Objectives: The aim of the study was to find evidence of SARS‐CoV‐2 infection in UK cats. Design: Tissue samples were tested for SARS‐CoV‐2 antigen using…”
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Snake Recombination Landscapes Are Concentrated in Functional Regions despite PRDM9 by Schield, Drew R, Pasquesi, Giulia I M, Perry, Blair W, Adams, Richard H, Nikolakis, Zachary L, Westfall, Aundrea K, Orton, Richard W, Meik, Jesse M, Mackessy, Stephen P, Castoe, Todd A

“…Abstract Meiotic recombination in vertebrates is concentrated in hotspots throughout the genome. The location and stability of hotspots have been linked to the…”
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Diversification of mammalian deltaviruses by host shifting by Bergner, Laura M., Orton, Richard J., Broos, Alice, Tello, Carlos, Becker, Daniel J., Carrera, Jorge E., Patel, Arvind H., Biek, Roman, Streicker, Daniel G.

“…Hepatitis delta virus (HDV) is an unusual RNA agent that replicates using host machinery but exploits hepatitis B virus (HBV) to mobilize its spread within and…”
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No evidence for distinct types in the evolution of SARS-CoV-2 by MacLean, Oscar A, Orton, Richard J, Singer, Joshua B, Robertson, David L

“…Abstract A recent study by Tang et al. claimed that two major types of severe acute respiratory syndrome-coronavirus-2 (CoV-2) had evolved in the ongoing CoV…”
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