Search Results - "Orton, Matthew R"

Intravoxel Incoherent Motion in Body Diffusion-Weighted MRI: Reality and Challenges by KOH, Dow-Mu, COLLINS, David J, ORTON, Matthew R

“…Diffusion-weighted MRI is increasingly applied in the body. It has been recognized for some time, on the basis of scientific experiments and studies in the…”
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Improved intravoxel incoherent motion analysis of diffusion weighted imaging by data driven Bayesian modeling by Orton, Matthew R., Collins, David J., Koh, Dow-Mu, Leach, Martin O.

“…In addition to the diffusion coefficient, fitting the intravoxel incoherent motion model to multiple b‐value diffusion‐weighted MR data gives pseudo‐diffusion…”
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Assessment of treatment response by total tumor volume and global apparent diffusion coefficient using diffusion-weighted MRI in patients with metastatic bone disease: a feasibility study by Blackledge, Matthew D, Collins, David J, Tunariu, Nina, Orton, Matthew R, Padhani, Anwar R, Leach, Martin O, Koh, Dow-Mu

“…We describe our semi-automatic segmentation of whole-body diffusion-weighted MRI (WBDWI) using a Markov random field (MRF) model to derive tumor total…”
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Inter- and Intra-Observer Repeatability of Quantitative Whole-Body, Diffusion-Weighted Imaging (WBDWI) in Metastatic Bone Disease by Blackledge, Matthew D, Tunariu, Nina, Orton, Matthew R, Padhani, Anwar R, Collins, David J, Leach, Martin O, Koh, Dow-Mu

“…Quantitative whole-body diffusion-weighted MRI (WB-DWI) is now possible using semi-automatic segmentation techniques. The method enables whole-body estimates…”
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Clinical application of machine learning models in patients with prostate cancer before prostatectomy by Guerra, Adalgisa, Orton, Matthew R, Wang, Helen, Konidari, Marianna, Maes, Kris, Papanikolaou, Nickolas K, Koh, Dow Mu

“…To build machine learning predictive models for surgical risk assessment of extracapsular extension (ECE) in patients with prostate cancer (PCa) before radical…”
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Prediction of extracapsular extension of prostate cancer by MRI radiomic signature: a systematic review by Guerra, Adalgisa, Wang, Helen, Orton, Matthew R., Konidari, Marianna, Papanikolaou, Nickolas K., Koh, Dow Mu, Donato, Helena, Alves, Filipe Caseiro

“…The objective of this review is to survey radiomics signatures for detecting pathological extracapsular extension (pECE) on magnetic resonance imaging (MRI) in…”
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Interpretability of radiomics models is improved when using feature group selection strategies for predicting molecular and clinical targets in clear-cell renal cell carcinoma: insights from the TRACERx Renal study by Orton, Matthew R, Hann, Evan, Doran, Simon J, Shepherd, Scott T C, Ap Dafydd, Derfel, Spencer, Charlotte E, López, José I, Albarrán-Artahona, Víctor, Comito, Francesca, Warren, Hannah, Shur, Joshua, Messiou, Christina, Larkin, James, Turajlic, Samra, Koh, Dow-Mu

“…The aim of this work is to evaluate the performance of radiomics predictions for a range of molecular, genomic and clinical targets in patients with clear cell…”
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Development of a temperature-controlled phantom for magnetic resonance quality assurance of diffusion, dynamic, and relaxometry measurements by Jerome, Neil P., Papoutsaki, Marianthi-Vasiliki, Orton, Matthew R., Parkes, Harold G., Winfield, Jessica M., Boss, Michael A., Leach, Martin O., deSouza, Nandita M., Collins, David J.

“…Purpose: Diffusion-weighted (DW) and dynamic contrast-enhanced magnetic resonance imaging (MRI) are increasingly applied for the assessment of functional…”
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Noise-Corrected, Exponentially Weighted, Diffusion-Weighted MRI (niceDWI) Improves Image Signal Uniformity in Whole-Body Imaging of Metastatic Prostate Cancer by Blackledge, Matthew D, Tunariu, Nina, Zungi, Fabio, Holbrey, Richard, Orton, Matthew R, Ribeiro, Ana, Hughes, Julie C, Scurr, Erica D, Collins, David J, Leach, Martin O, Koh, Dow-Mu

“…To characterize the voxel-wise uncertainties of Apparent Diffusion Coefficient (ADC) estimation from whole-body diffusion-weighted imaging (WBDWI). This…”
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DCE-MRI is more sensitive than IVIM-DWI for assessing anti-angiogenic treatment-induced changes in colorectal liver metastases by Rata, Mihaela, Khan, Khurum, Collins, David J, Koh, Dow-Mu, Tunariu, Nina, Bali, Maria Antonietta, d'Arcy, James, Winfield, Jessica M, Picchia, Simona, Valeri, Nicola, Chau, Ian, Cunningham, David, Fassan, Matteo, Leach, Martin O, Orton, Matthew R

“…Diffusion weighted imaging (DWI) with intravoxel incoherent motion (IVIM) modelling can inform on tissue perfusion without exogenous contrast administration…”
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Radiomic Features From Diffusion-Weighted MRI of Retroperitoneal Soft-Tissue Sarcomas Are Repeatable and Exhibit Change After Radiotherapy by Thrussell, Imogen, Winfield, Jessica M, Orton, Matthew R, Miah, Aisha B, Zaidi, Shane H, Arthur, Amani, Thway, Khin, Strauss, Dirk C, Collins, David J, Koh, Dow-Mu, Oelfke, Uwe, Huang, Paul H, O'Connor, James P B, Messiou, Christina, Blackledge, Matthew D

“…Size-based assessments are inaccurate indicators of tumor response in soft-tissue sarcoma (STS), motivating the requirement for new response imaging biomarkers…”
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Microstructure Characterization of Bone Metastases from Prostate Cancer with Diffusion MRI: Preliminary Findings by Bailey, Colleen, Collins, David J, Tunariu, Nina, Orton, Matthew R, Morgan, Veronica A, Feiweier, Thorsten, Hawkes, David J, Leach, Martin O, Alexander, Daniel C, Panagiotaki, Eleftheria

“…To examine the usefulness of rich diffusion protocols with high -values and varying diffusion time for probing microstructure in bone metastases. Analysis…”
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Radiomics in Oncology: A Practical Guide by Shur, Joshua D., Doran, Simon J., Kumar, Santosh, ap Dafydd, Derfel, Downey, Kate, O’Connor, James P. B., Papanikolaou, Nikolaos, Messiou, Christina, Koh, Dow-Mu, Orton, Matthew R.

“…Radiomics refers to the extraction of mineable data from medical imaging and has been applied within oncology to improve diagnosis, prognostication, and…”
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Stacked Autoencoders for Unsupervised Feature Learning and Multiple Organ Detection in a Pilot Study Using 4D Patient Data by Hoo-Chang Shin, Orton, M. R., Collins, D. J., Doran, S. J., Leach, M. O.

“…Medical image analysis remains a challenging application area for artificial intelligence. When applying machine learning, obtaining ground-truth labels for…”
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Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data by Hill, Deborah K, Orton, Matthew R, Mariotti, Erika, Boult, Jessica K R, Panek, Rafal, Jafar, Maysam, Parkes, Harold G, Jamin, Yann, Miniotis, Maria Falck, Al-Saffar, Nada M S, Beloueche-Babari, Mounia, Robinson, Simon P, Leach, Martin O, Chung, Yuen-Li, Eykyn, Thomas R

“…Real-time detection of the rates of metabolic flux, or exchange rates of endogenous enzymatic reactions, is now feasible in biological systems using Dynamic…”
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Reduced Warburg effect in cancer cells undergoing autophagy: steady- state 1H-MRS and real-time hyperpolarized 13C-MRS studies by Lin, Gigin, Andrejeva, Gabriela, Wong Te Fong, Anne-Christine, Hill, Deborah K, Orton, Matthew R, Parkes, Harry G, Koh, Dow-Mu, Robinson, Simon P, Leach, Martin O, Eykyn, Thomas R, Chung, Yuen-Li

“…Autophagy is a highly regulated, energy dependent cellular process where proteins, organelles and cytoplasm are sequestered in autophagosomes and digested to…”
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Probing structure of normal and malignant prostate tissue before and after radiation therapy with luminal water fraction and diffusion‐weighted MRI by Carlin, Dominic, Orton, Matthew R., Collins, David, deSouza, Nandita M.

“…Background Interpretation of diffusion in conjunction with T2‐weighted MRI is essential for assessing prostate cancer; however, the combination of apparent…”
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Repeatability of quantitative MR fingerprinting for T1 and T2 measurements of metastatic bone in prostate cancer patients by Rata, Mihaela, Orton, Matthew R., Tunariu, Nina, Curcean, Andra, Hughes, Julie, Scurr, Erica, Blackledge, Matthew, d’Arcy, James, Jiang, Yun, Gulani, Vikas, Koh, Dow-Mu

“…Abstract Objectives MR fingerprinting (MRF) has the potential to quantify treatment response. This study evaluated the repeatability of MRF-derived T 1 and T 2…”
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Evaluation of simultaneous multi-slice acquisition with advanced processing for free-breathing diffusion-weighted imaging in patients with liver metastasis by Rata, Mihaela, De Paepe, Katja N., Orton, Matthew R., Castagnoli, Francesca, d’Arcy, James, Winfield, Jessica M., Hughes, Julie, Stemmer, Alto, Nickel, Marcel Dominik, Koh, Dow-Mu

“…Objectives Diffusion-weighted imaging (DWI) with simultaneous multi-slice (SMS) acquisition and advanced processing can accelerate acquisition time and improve…”
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A CT-based radiomics classification model for the prediction of histological type and tumour grade in retroperitoneal sarcoma (RADSARC-R): a retrospective multicohort analysis by Arthur, Amani, Orton, Matthew R, Emsley, Robby, Vit, Sharon, Kelly-Morland, Christian, Strauss, Dirk, Lunn, Jason, Doran, Simon, Lmalem, Hafida, Nzokirantevye, Axelle, Litiere, Saskia, Bonvalot, Sylvie, Haas, Rick, Gronchi, Alessandro, Van Gestel, Dirk, Ducassou, Anne, Raut, Chandrajit P, Meeus, Pierre, Spalek, Mateusz, Hatton, Matthew, Le Pechoux, Cecile, Thway, Khin, Fisher, Cyril, Jones, Robin, Huang, Paul H, Messiou, Christina

“…Retroperitoneal sarcomas are tumours with a poor prognosis. Upfront characterisation of the tumour is difficult, and under-grading is common. Radiomics has the…”
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