Search Results - "Ortiz‐Espinosa, Sergio"

Gene knock-outs in human CD34+ hematopoietic stem and progenitor cells and in the human immune system of mice by Kuppers, Daniel A, Linton, Jonathan, Ortiz Espinosa, Sergio, McKenna, Kelly M, Rongvaux, Anthony, Paddison, Patrick J

“…Human CD34+ hematopoietic stem and progenitor cells (HSPCs) are a standard source of cells for clinical HSC transplantations as well as experimental…”
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Design and validation of a tunable inertial microfluidic system for the efficient enrichment of circulating tumor cells in blood by Rodríguez‐Pena, Alejandro, Armendariz, Estibaliz, Oyarbide, Alvaro, Morales, Xabier, Ortiz‐Espinosa, Sergio, Ruiz‐Fernández de Córdoba, Borja, Cochonneau, Denis, Cornago, Iñaki, Heymann, Dominique, Argemi, Josepmaría, D'Avola, Delia, Sangro, Bruno, Lecanda, Fernando, Pio, Ruben, Cortés‐Domínguez, Iván, Ortiz‐de‐Solórzano, Carlos

“…The analysis of circulating tumor cells (CTCs) in blood is a powerful noninvasive alternative to conventional tumor biopsy. Inertial‐based separation is a…”
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Complementing the Cancer-Immunity Cycle by Pio, Ruben, Ajona, Daniel, Ortiz-Espinosa, Sergio, Mantovani, Alberto, Lambris, John D

“…Reactivation of cytotoxic CD8 T-cell responses has set a new direction for cancer immunotherapy. Neutralizing antibodies targeting immune checkpoint programmed…”
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A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis by Ajona, Daniel, Ortiz-Espinosa, Sergio, Moreno, Haritz, Lozano, Teresa, Pajares, María J, Agorreta, Jackeline, Bértolo, Cristina, Lasarte, Juan J, Vicent, Silvestre, Hoehlig, Kai, Vater, Axel, Lecanda, Fernando, Montuenga, Luis M, Pio, Ruben

“…Disruption of the programmed cell death protein 1 (PD-1) pathway with immune checkpoint inhibitors represents a major breakthrough in the treatment of…”
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Complement in Metastasis: A Comp in the Camp by Ajona, Daniel, Ortiz-Espinosa, Sergio, Pio, Ruben, Lecanda, Fernando

“…The complement system represents a pillar of the innate immune response. This system, critical for host defense against pathogens, encompasses more than 50…”
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SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation by Redin, Esther, Garmendia, Irati, Lozano, Teresa, Serrano, Diego, Senent, Yaiza, Redrado, Miriam, Villalba, Maria, De Andrea, Carlos E, Exposito, Francisco, Ajona, Daniel, Ortiz-Espinosa, Sergio, Remirez, Ana, Bertolo, Cristina, Sainz, Cristina, Garcia-Pedrero, Juana, Pio, Ruben, Lasarte, Juan, Agorreta, Jackeline, Montuenga, Luis M, Calvo, Alfonso

“…IntroductionThe use of immune-checkpoint inhibitors has drastically improved the management of patients with non-small cell lung cancer (NSCLC), but innate and…”
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Complement anaphylatoxins C3a and C5a: Emerging roles in cancer progression and treatment by Ajona, Daniel, Ortiz-Espinosa, Sergio, Pio, Ruben

“…Recent insights into the role of complement anaphylatoxins C3a and C5a in cancer provide new opportunities for the development of innovative biomarkers and…”
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Bursting Tumor Bubbles to Improve CAR T-cell Therapy by Ortiz-Espinosa, Sergio, Srivastava, Shivani

“…Chimeric antigen receptor (CAR) T cells have had dramatic success in B-cell malignancies, but this efficacy has not yet translated to more common solid tumors…”
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Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis by Ortiz-Espinosa, Sergio, Morales, Xabier, Senent, Yaiza, Alignani, Diego, Tavira, Beatriz, Macaya, Irati, Ruiz, Borja, Moreno, Haritz, Remírez, Ana, Sainz, Cristina, Rodriguez-Pena, Alejandro, Oyarbide, Alvaro, Ariz, Mikel, Andueza, Maria P., Valencia, Karmele, Teijeira, Alvaro, Hoehlig, Kai, Vater, Axel, Rolfe, Barbara, Woodruff, Trent M., Lopez-Picazo, Jose Maria, Vicent, Silvestre, Kochan, Grazyna, Escors, David, Gil-Bazo, Ignacio, Perez-Gracia, Jose Luis, Montuenga, Luis M., Lambris, John D., Ortiz de Solorzano, Carlos, Lecanda, Fernando, Ajona, Daniel, Pio, Ruben

“…Myeloid-derived suppressor cells (MDSCs) play a major role in cancer progression. In this study, we investigated the mechanisms by which complement C5a…”
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Blockade of the Complement C5a/C5aR1 Axis Impairs Lung Cancer Bone Metastasis by CXCL16-mediated Effects by Ajona, Daniel, Zandueta, Carolina, Corrales, Leticia, Moreno, Haritz, Pajares, María J, Ortiz-Espinosa, Sergio, Martínez-Terroba, Elena, Perurena, Naiara, de Miguel, Fernando J, Jantus-Lewintre, Eloisa, Camps, Carlos, Vicent, Silvestre, Agorreta, Jackeline, Montuenga, Luis M, Pio, Ruben, Lecanda, Fernando

“…C5aR1 (CD88), a receptor for complement anaphylatoxin C5a, is a potent immune mediator. Its impact on malignant growth and dissemination of non-small cell lung…”
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FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted by Vallejo, Adrián, Erice, Oihane, Entrialgo-Cadierno, Rodrigo, Feliu, Iker, Guruceaga, Elizabeth, Perugorria, Maria J., Olaizola, Paula, Muggli, Alexandra, Macaya, Irati, O’Dell, Michael, Ruiz-Fernandez de Cordoba, Borja, Ortiz-Espinosa, Sergio, Hezel, Aram F., Arozarena, Imanol, Lecanda, Fernando, Avila, Matias A., Fernandez-Barrena, Maite G., Evert, Matthias, Ponz-Sarvise, Mariano, Calvisi, Diego F., Banales, Jesus M., Vicent, Silve

“…Cholangiocarcinoma (CCA) is a neoplasia of the biliary tract driven by genetic, epigenetic and transcriptional mechanisms. Herein, we investigated the role of…”
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Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer by Ruiz-Fernández de Córdoba, Borja, Moreno, Haritz, Valencia, Karmele, Perurena, Naiara, Ruedas, Pablo, Walle, Thomas, Pezonaga-Torres, Alberto, Hinojosa, Juan, Guruceaga, Elisabet, Pineda-Lucena, Antonio, Abengózar-Muela, Marta, Cochonneau, Denis, Zandueta, Carolina, Martínez-Canarias, Susana, Teijeira, Álvaro, Ajona, Daniel, Ortiz-Espinosa, Sergio, Morales, Xabier, Ortiz de Solórzano, Carlos, Santisteban, Marta, Ramos-García, Luis I, Guembe, Laura, Strnad, Vratislav, Heymann, Dominique, Hervás-Stubbs, Sandra, Pío, Rubén, Rodríguez-Ruiz, María E, de Andrea, Carlos E, Vicent, Silvestre, Melero, Ignacio, Lecanda, Fernando, Martínez-Monge, Rafael

“…Locoregional failure (LRF) in patients with breast cancer post-surgery and post-irradiation is linked to a dismal prognosis. In a refined new model, we…”
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Abstract B043: BDNF-TrkB.T1 signaling increases neutrophil recruitment and epithelial-to- mesenchymal transition in gliomas by Merino-Galan, Leyre, Ortiz-Espinosa, Sergio, Jagana, Hawa L., Hemenway, John M., Rajendran, Ashmitha, Jackson, Taylor S., Kuppers, Daniel A., Arora, Sonali, Paddison, Patrick J., Pattwell, Siobhan S.

“…Abstract Gliomas are the most common type of brain tumor in both children and adults. Communication between glioma cells and the brain tumor microenvironment…”
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Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade by Ajona, Daniel, Ortiz-Espinosa, Sergio, Lozano, Teresa, Exposito, Francisco, Calvo, Alfonso, Valencia, Karmele, Redrado, Miriam, Remírez, Ana, Lecanda, Fernando, Alignani, Diego, Lasarte, Juan J, Macaya, Irati, Senent, Yaiza, Bértolo, Cristina, Sainz, Cristina, Gil-Bazo, Ignacio, Eguren-Santamaría, Iñaki, Lopez-Picazo, Jose M, Gonzalez, Alvaro, Perez-Gracia, Jose L, de Andrea, Carlos E, Vicent, Silvestre, Sanmamed, Miguel F, Montuenga, Luis M, Pio, Ruben

“…Harnessing the immune system by blocking the programmed cell death protein 1 (PD-1) pathway has been a major breakthrough in non-small-cell lung cancer…”
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Id1 and PD-1 Combined Blockade Impairs Tumor Growth and Survival of KRAS-mutant Lung Cancer by Stimulating PD-L1 Expression and Tumor Infiltrating CD8+ T Cells by Baraibar, Iosune, Roman, Marta, Rodríguez-Remírez, María, López, Inés, Vilalta, Anna, Guruceaga, Elisabeth, Ecay, Margarita, Collantes, María, Lozano, Teresa, Alignani, Diego, Puyalto, Ander, Oliver, Ana, Ortiz-Espinosa, Sergio, Moreno, Haritz, Torregrosa, María, Rolfo, Christian, Caglevic, Christian, García-Ros, David, Villalba-Esparza, María, De Andrea, Carlos, Vicent, Silvestre, Pío, Rubén, Lasarte, Juan José, Calvo, Alfonso, Ajona, Daniel, Gil-Bazo, Ignacio

“…The use of PD-1/PD-L1 checkpoint inhibitors in advanced NSCLC is associated with longer survival. However, many patients do not benefit from PD-1/PD-L1…”
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Id1 and PD-1 Combined Blockade Impairs Tumor Growth and Survival of KRAS-mutant Lung Cancer by Stimulating PD-L1 Expression and Tumor Infiltrating [CD8.sup.+] T Cells by Baraibar, Iosune, Roman, Marta, Rodriguez-Remirez, Maria, Lopez, Ines, Vilalta, Anna, Guruceaga, Elisabeth, Ecay, Margarita, Collantes, Maria, Lozano, Teresa, Alignani, Diego, Puyalto, Ander, Oliver, Ana, Ortiz-Espinosa, Sergio, Moreno, Haritz, Torregrosa, Maria, Rolfo, Christian, Caglevic, Christian, Garcia-Ros, David, Villalba-Esparza, Maria, de Andrea, Carlos, Vicent, Silvestre, Pio, Ruben, Lasarte, Juan Jose, Calvo, Alfonso, Ajona, Daniel, Gil-Bazo, Ignacio

“…Lung adenocarcinoma is the most frequent lung cancer subtype. Many of those adenocarcinomas of the lung are driven by the KRAS gene. Although immunotherapy has…”
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