Search Results - "Ortiz Mellet, Carmen"

Carbohydrate supramolecular chemistry: beyond the multivalent effect by González-Cuesta, Manuel, Ortiz Mellet, Carmen, García Fernández, José M

“…It has been amply constated that sugar ligand multivalency increases lectin-binding avidities dramatically, thereby modulating the capacity of carbohydrates to…”
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Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases by Sánchez-Fernández, Elena M, García Fernández, José M, Mellet, Carmen Ortiz

“…Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking of enzymes, leading to premature…”
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pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases by Mena-Barragán, Teresa, Narita, Aya, Matias, Dino, Tiscornia, Gustavo, Nanba, Eiji, Ohno, Kousaku, Suzuki, Yoshiyuki, Higaki, Katsumi, Garcia Fernández, José Manuel, Ortiz Mellet, Carmen

“…A general approach is reported for the design of small‐molecule competitive inhibitors of lysosomal glycosidases programmed to 1) promote correct folding of…”
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High‐Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC‐SIGN and Langerin by Herrera‐González, Irene, González‐Cuesta, Manuel, Thépaut, Michel, Laigre, Eugénie, Goyard, David, Rojo, Javier, García Fernández, José M., Fieschi, Franck, Renaudet, Olivier, Nieto, Pedro M., Ortiz Mellet, Carmen

“…The “carbohydrate chemical mimicry” exhibited by sp2‐iminosugars has been utilized to develop practical syntheses for analogs of the branched high‐mannose‐type…”
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Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect by Compain, Philippe, Decroocq, Camille, Iehl, Julien, Holler, Michel, Hazelard, Damien, Mena Barragán, Teresa, Ortiz Mellet, Carmen, Nierengarten, Jean-François

“…Superball! A dodecavalent iminosugar derivative with a fullerene core (see picture) shows a binding enhancement of up to three orders of magnitude over the…”
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Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice by Arroba, Ana I., Alcalde-Estevez, Elena, García-Ramírez, Marta, Cazzoni, Daniele, de la Villa, Pedro, Sánchez-Fernández, Elena M., Mellet, Carmen Ortiz, García Fernández, José M., Hernández, Cristina, Simó, Rafael, Valverde, Ángela M.

“…Retinal diseases linked to inflammation are often accompanied by macrophage/microglial cells activation. However, the dynamics between M1 (pro-inflammatory)…”
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Potent and Selective Cell‐Active Iminosugar Inhibitors of Human α‐N‐Acetylgalactosaminidase (α‐NAGAL) by Ashmus, Roger A., Wang, Yang, González‐Cuesta, Manuel, King, Dustin T., Tiet, Ben, Chen, Xi, Zhu, Yanping, Kirk, Bryce, García Fernandez, José M., Ortiz Mellet, Carmen, Britton, Robert, Vocadlo, David J.

“…Glycoside hydrolases (GHs) are a class of enzymes with emerging roles in a range of disease. Selective GH inhibitors are sought to better understand their…”
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Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications by González-Cuesta, Manuel, Sidhu, Peter, Ashmus, Roger A, Males, Alexandra, Proceviat, Cameron, Madden, Zarina, Rogalski, Jason C, Busmann, Jil A, Foster, Leonard J, García Fernández, José M, Davies, Gideon J, Ortiz Mellet, Carmen, Vocadlo, David J

“…Owing to its roles in human health and disease, the modification of nuclear, cytoplasmic, and mitochondrial proteins with O-linked N-acetylglucosamine residues…”
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Trifaceted Mickey Mouse Amphiphiles for Programmable Self‐Assembly, DNA Complexation and Organ‐Selective Gene Delivery by Carbajo‐Gordillo, Ana I., González‐Cuesta, Manuel, Jiménez Blanco, José L., Benito, Juan M., Santana‐Armas, María L., Carmona, Thais, Di Giorgio, Christophe, Przybylski, Cédric, Ortiz Mellet, Carmen, Tros de Ilarduya, Conchita, Mendicuti, Francisco, García Fernández, José M.

“…Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose‐based trifaceted macrocyclic scaffold allows engineering…”
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Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery by Varan, Gamze, Benito, Juan M, Mellet, Carmen Ortiz, Bilensoy, Erem

“…Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its bioavailability problems arising from very poor…”
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The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study by García‐Moreno, M. Isabel, Ortega‐Caballero, Fernando, Rísquez‐Cuadro, Rocío, Ortiz Mellet, Carmen, García Fernández, José M.

“…The vision of multivalency as a strategy limited to achieve affinity enhancements between a protein receptor and its putative sugar ligand (glycotope) has…”
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Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis by Manzanares, Darío, Pérez-Carrión, María Dolores, Jiménez Blanco, José Luis, Ortiz Mellet, Carmen, García Fernández, José Manuel, Ceña, Valentín

“…Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics since it can knockdown very efficiently the target protein. It is…”
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Pharmacological chaperone therapy for Gaucher disease: a patent review by Benito, Juan M, García Fernández, José M, Ortiz Mellet, Carmen

“…Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher disease (GD), which give rise to significant…”
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Plasmid‐Templated Control of DNA–Cyclodextrin Nanoparticle Morphology through Molecular Vector Design for Effective Gene Delivery by Gallego‐Yerga, Laura, Benito, Juan M., Blanco‐Fernández, Laura, Martínez‐Negro, María, Vélaz, Itziar, Aicart, Emilio, Junquera, Elena, Ortiz Mellet, Carmen, Tros de Ilarduya, Conchita, García Fernández, Jose M.

“…Engineering self‐assembled superstructures through complexation of plasmid DNA (pDNA) and single‐isomer nanometric size macromolecules (molecular…”
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Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery by Díaz-Moscoso, Alejandro, Guilloteau, Nicolas, Bienvenu, Céline, Méndez-Ardoy, Alejandro, Jiménez Blanco, José L, Benito, Juan M, Le Gourriérec, Loïc, Di Giorgio, Christophe, Vierling, Pierre, Defaye, Jacques, Ortiz Mellet, Carmen, García Fernández, José M

“…Abstract Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a multi-tail hydrophobic moiety…”
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Polycationic Amphiphilic Cyclodextrins for Gene Delivery: Synthesis and Effect of Structural Modifications on Plasmid DNA Complex Stability, Cytotoxicity, and Gene Expression by Díaz-Moscoso, Alejandro, Le Gourriérec, Löic, Gómez-García, Marta, Benito, Juan M., Balbuena, Patricia, Ortega-Caballero, Fernando, Guilloteau, Nicolas, Di Giorgio, Christophe, Vierling, Pierre, Defaye, Jacques, Ortiz Mellet, Carmen, García Fernández, José M.

“…A molecular‐diversity‐oriented approach for the preparation of well‐defined polycationic amphiphilic cyclodextrins (paCDs) as gene‐delivery systems is…”
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Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells by Gallego-Yerga, Laura, Posadas, Inmaculada, de la Torre, Cristina, Ruiz-Almansa, Jesús, Sansone, Francesco, Ortiz Mellet, Carmen, Casnati, Alessandro, García Fernández, José M, Ceña, Valentín

“…Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA ) module undergo self-assembly in aqueous media…”
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Cyclodextrin-Based Functional Glyconanomaterials by Rivero-Barbarroja, Gonzalo, Benito, Juan Manuel, Ortiz Mellet, Carmen, García Fernández, José Manuel

“…Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as "off-the-shelve" tools to manipulate the pharmacokinetics of…”
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Synthesis of High-Mannose Oligosaccharide Analogues through Click Chemistry: True Functional Mimics of Their Natural Counterparts Against Lectins? by François-Heude, Marc, Méndez-Ardoy, Alejandro, Cendret, Virginie, Lafite, Pierre, Daniellou, Richard, Ortiz Mellet, Carmen, García Fernández, José M., Moreau, Vincent, Djedaïni-Pilard, Florence

“…Terminal “high‐mannose oligosaccharides” are involved in a broad range of biological and pathological processes, from sperm‐egg fusion to influenza and human…”
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Insights in cellular uptake mechanisms of pDNA–polycationic amphiphilic cyclodextrin nanoparticles (CDplexes) by Díaz-Moscoso, Alejandro, Vercauteren, Dries, Rejman, Joanna, Benito, Juan M., Ortiz Mellet, Carmen, De Smedt, Stefaan C., Fernández, José M. García

“…It is generally recognized that the major obstacle to efficient gene delivery is cellular internalization and endosomal escape of the DNA. Recently, we have…”
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