Search Results - "Ortiz, Rodrigo"
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The Role of Transcription Factors in the Loss of Inter-Chromosomal Co-Expression for Breast Cancer Subtypes
Published in International journal of molecular sciences (01-12-2023)“…Breast cancer encompasses a diverse array of subtypes, each exhibiting distinct clinical characteristics and treatment responses. Unraveling the underlying…”
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Porous Honeycomb Self-Assembled Monolayers: Tripodal Adsorption and Hidden Chirality of Carboxylate Anchored Triptycenes on Ag
Published in ACS nano (27-07-2021)“…Molecules with tripodal anchoring to substrates represent a versatile platform for the fabrication of robust self-assembled monolayers (SAMs), complementing…”
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A systematic review of the biological mediators of fat taste and smell
Published in Physiological reviews (01-01-2023)“…Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly palatable energy-dense foods can lead to increased caloric intake…”
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Characterization of Apo‐Form Selective Inhibition of Indoleamine 2,3‐Dioxygenase
Published in Chembiochem : a European journal of chemical biology (02-02-2021)“…Indoleamine‐2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that catalyzes the rate‐limiting step in the kynurenine pathway of tryptophan (TRP)…”
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Using Wood Rot Phenotypes to Illuminate the “Gray” Among Decomposer Fungi
Published in Frontiers in microbiology (12-06-2020)“…Wood-decomposing fungi use distinct strategies to deconstruct wood that can significantly vary carbon release rates and fates. White and brown rot-type fungi…”
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Toward the Characterization of DAPT Interactions with γ‐Secretase
Published in ChemMedChem (17-05-2019)“…DAPT is a potent γ‐secretase (GS) inhibitor that blocks the production of short amyloid‐β (Aβ) peptides. Aggregation and oligomerization of Aβ peptides have…”
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Visualization of the Hybrid State of tRNA Binding Promoted by Spontaneous Ratcheting of the Ribosome
Published in Molecular cell (24-10-2008)“…A crucial step in translation is the translocation of tRNAs through the ribosome. In the transition from one canonical site to the other, the tRNAs acquire…”
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Approximation of a Convective-Event-Monitoring System Using GOES-R Data and Ensemble ML Models
Published in Remote sensing (Basel, Switzerland) (01-02-2024)“…The presence of deep convective clouds is directly related to potential convective hazards, such as lightning strikes, hail, severe storms, flash floods, and…”
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Exploring gender stereotypes in financial reporting: An aspect-level sentiment analysis using big data and deep learning
Published in Heliyon (30-10-2024)“…This study delves into the intricate interplay between gender stereotypes and financial reporting through an aspect-level sentiment analysis approach…”
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Synthesis of Quinazolin‐2,4,6‐triamine Derivatives as Non‐purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential
Published in ChemMedChem (17-10-2023)“…In this work, a new set of quinazolin‐2,4,6‐triamine derivatives were synthesized to explore their potential biological activity as xanthine oxidase (XO)…”
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In Silico Characterization of Masitinib Interaction with SARS‐CoV‐2 Main Protease
Published in ChemMedChem (05-08-2021)“…Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection continues to be a global health problem. Despite the current implementation of COVID‐19…”
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Structural characterization of mRNA-tRNA translocation intermediates
Published in Proceedings of the National Academy of Sciences - PNAS (17-04-2012)“…Cryo-EM analysis of a wild-type Escherichia coli pretranslocational sample has revealed the presence of previously unseen intermediate substates of the…”
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Impact of R&D on the Innovation of Products and Processes in Latin Countries
Published in Axioms (01-02-2023)“…According to the literature on innovation, several vital factors or determinants favor innovation in companies. In the case of R&D, significant advances have…”
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Generation of Amyloid‐β Peptides by γ‐Secretase
Published in Israel journal of chemistry (01-07-2017)“…γ‐Secretase is a four‐component membrane‐embedded aspartyl protease involved in the final cleavage step of the amyloid precursor protein (APP) to generate the…”
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Identification and In Silico Characterization of Novel Helicobacter pylori Glucose-6-Phosphate Dehydrogenase Inhibitors
Published in Molecules (Basel, Switzerland) (16-08-2021)“…Helicobacter pylori (H. pylori) is a pathogen that can remain in the stomach of an infected person for their entire life. As a result, this leads to the…”
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Evaluation of New Benzimidazole Derivatives as Cysticidal Agents: In Vitro, in Vivo and Docking Studies
Published in Chemical & pharmaceutical bulletin (01-12-2019)“…Based on our previous research on cysticidal drugs, we report the synthesis and evaluation of three new benzimidazole derivatives. In these compounds, the…”
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Design, Synthesis and Evaluation of 2,4‐Diaminoquinazoline Derivatives as Potential Tubulin Polymerization Inhibitors
Published in ChemMedChem (05-10-2020)“…Microtubules are highly dynamic polymers composed of α‐ and β‐tubulin proteins that have been shown to be potential therapeutic targets for the development of…”
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Structure‐based approaches for the design of benzimidazole‐2‐carbamate derivatives as tubulin polymerization inhibitors
Published in Chemical biology & drug design (01-07-2017)“…Microtubules are highly dynamic assemblies of α/β‐tubulin heterodimers whose polymerization inhibition is among one of the most successful approaches for…”
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Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities
Published in International journal of molecular sciences (10-06-2020)“…Sarcoendoplasmic reticulum calcium ATPase (SERCA), a member of the P-type ATPase family of ion and lipid pumps, is responsible for the active transport of Ca…”
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