Search Results - "Ortines, Roger V"

Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus-Infected Wounds in Nondiabetic and Diabetic Mice by Ortines, Roger V, Liu, Haiyun, Cheng, Lily I, Cohen, Taylor S, Lawlor, Heather, Gami, Abhishek, Wang, Yu, Dillen, Carly A, Archer, Nathan K, Miller, Robert J, Ashbaugh, Alyssa G, Pinsker, Bret L, Marchitto, Mark C, Tkaczyk, Christine, Stover, C Kendall, Sellman, Bret R, Miller, Lloyd S

“…wound infections delay healing and result in invasive complications such as osteomyelitis, especially in the setting of diabetic foot ulcers. In preclinical…”
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The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection by Gordon, Oren, Dikeman, Dustin A, Ortines, Roger V, Wang, Yu, Youn, Christine, Mumtaz, Mohammed, Orlando, Nicholas, Zhang, Jeffrey, Patel, Aman M, Gough, Ethan, Kaushik, Amit, Nuermberger, Eric L, Upton, Anna M, Fotouhi, Nader, Miller, Lloyd S, Archer, Nathan K

“…Staphylococcus aureus is an important cause of various infections in humans, including bacteremia, skin and soft tissue infections, and infections associated…”
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Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe by Romero Pastrana, Francisco, Thompson, John M., Heuker, Marjolein, Hoekstra, Hedzer, Dillen, Carly A., Ortines, Roger V., Ashbaugh, Alyssa G., Pickett, Julie E., Linssen, Matthijs D., Bernthal, Nicholas M., Francis, Kevin P., Buist, Girbe, van Oosten, Marleen, van Dam, Gooitzen M., Thorek, Daniel L. J., Miller, Lloyd S., van Dijl, Jan Maarten

“…Staphylococcus aureus infections are a major threat in healthcare, requiring adequate early-stage diagnosis and treatment. This calls for novel diagnostic…”
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Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses by Liu, Haiyun, Archer, Nathan K., Dillen, Carly A., Wang, Yu, Ashbaugh, Alyssa G., Ortines, Roger V., Kao, Tracy, Lee, Steven K., Cai, Shuting S., Miller, Robert J., Marchitto, Mark C., Zhang, Emily, Riggins, Daniel P., Plaut, Roger D., Stibitz, Scott, Geha, Raif S., Miller, Lloyd S.

“…Staphylococcus aureus colonization contributes to skin inflammation in diseases such as atopic dermatitis, but the signaling pathways involved are unclear…”
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IL-6R/Signal Transducer and Activator of Transcription 3 Signaling in Keratinocytes rather than in T Cells Induces Psoriasis-Like Dermatitis in Mice by Ravipati, Advaitaa, Nolan, Sabrina, Alphonse, Martin, Dikeman, Dustin, Youn, Christine, Wang, Yu, Orlando, Nicholas, Patrick, Garrett, Lee, Steven, Ortines, Roger V., Liu, Haiyun, Miller, Robert J., Dillen, Carly A., Marchitto, Mark, Cai, S. Sarah, Miller, Lloyd S., Archer, Nathan K.

“…Signal transducer and activator of transcription 3 (STAT3) is important for psoriasis pathogenesis because STAT3 signaling downstream of IL-6, IL-21, IL-22,…”
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Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection by Dong, Xintong, Limjunyawong, Nathachit, Sypek, Elizabeth I, Wang, Gaofeng, Ortines, Roger V, Youn, Christine, Alphonse, Martin P, Dikeman, Dustin, Wang, Yu, Lay, Mark, Kothari, Ruchita, Vasavda, Chirag, Pundir, Priyanka, Goff, Loyal, Miller, Lloyd S, Lu, Wuyuan, Garza, Luis A, Kim, Brian S, Archer, Nathan K, Dong, Xinzhong

“…Healthy skin maintains a diverse microbiome and a potent immune system to fight off infections. Here, we discovered that the epithelial-cell-derived…”
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Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1α release by Archer, Nathan K., Jo, Jay-Hyun, Lee, Steven K., Kim, Dongwon, Smith, Barbara, Ortines, Roger V., Wang, Yu, Marchitto, Mark C., Ravipati, Advaitaa, Cai, Shuting S., Dillen, Carly A., Liu, Haiyun, Miller, Robert J., Ashbaugh, Alyssa G., Uppal, Angad S., Oyoshi, Michiko K., Malhotra, Nidhi, Hoff, Sabine, Garza, Luis A., Kong, Heidi H., Segre, Julia A., Geha, Raif S., Miller, Lloyd S.

“…Atopic dermatitis (AD) is associated with epidermal barrier defects, dysbiosis, and skin injury caused by scratching. In particular, the barrier-defective…”
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Divergent Tumor Necrosis Factor Receptor-Related Remodeling Responses in Heart Failure : Role of Nuclear Factor-κB and Inflammatory Activation by HAMID, Tariq, YAN GU, ORTINES, Roger V, BHATTACHARYA, Chhandashri, GUANGWU WANG, XUAN, Yu-Ting, PRABHU, Sumanth D

“…Background— Although preclinical data suggested that tumor necrosis factor-α (TNF) neutralization in heart failure (HF) would be beneficial, clinical trials of…”
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Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease by Patrick, Garrett J, Liu, Haiyun, Alphonse, Martin P, Dikeman, Dustin A, Youn, Christine, Otterson, Jack C, Wang, Yu, Ravipati, Advaitaa, Mazhar, Momina, Denny, George, Ortines, Roger V, Zhang, Emily, Miller, Robert J, Dillen, Carly A, Liu, Qi, Nolan, Sabrina J, Nguyen, Kristine, Marcello, LeeAnn, Do, Danh C, Wier, Eric M, Zhang, Yan, Caviness, Gary, Klimowicz, Alexander C, Mierz, Diane V, Fine, Jay S, Sun, Guangping, Goldbach-Mansky, Raphaela, Marusina, Alina I, Merleev, Alexander A, Maverakis, Emanual, Garza, Luis A, Milner, Joshua D, Gao, Peisong, Ramanujam, Meera, Raymond, Ernest L, Archer, Nathan K, Miller, Lloyd S

“…IgE induced by type 2 immune responses in atopic dermatitis is implicated in the progression of atopic dermatitis to other allergic diseases, including food…”
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Clonal Vγ6⁺Vδ4⁺ T cells promote IL-17–mediated immunity against Staphylococcus aureus skin infection by Marchitto, Mark C., Dillen, Carly A., Liu, Haiyun, Miller, Robert J., Archer, Nathan K., Ortines, Roger V., Alphonse, Martin P., Marusina, Alina I., Merleev, Alexander A., Wang, Yu, Pinsker, Bret L., Byrd, Angel S., Brown, Isabelle D., Ravipati, Advaitaa, Zhang, Emily, Cai, Shuting S., Limjunyawong, Nathachit, Dong, Xinzhong, Yeaman, Michael R., Simon, Scott I., Shen, Wei, Durum, Scott K., O’Brien, Rebecca L., Maverakis, Emanual, Miller, Lloyd S.

“…T cell cytokines contribute to immunity against Staphylococcus aureus, but the predominant T cell subsets involved are unclear. In an S. aureus skin infection…”
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Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection by Dillen, Carly A, Pinsker, Bret L, Marusina, Alina I, Merleev, Alexander A, Farber, Orly N, Liu, Haiyun, Archer, Nathan K, Lee, Da B, Wang, Yu, Ortines, Roger V, Lee, Steven K, Marchitto, Mark C, Cai, Shuting S, Ashbaugh, Alyssa G, May, Larissa S, Holland, Steven M, Freeman, Alexandra F, Miller, Loren G, Yeaman, Michael R, Simon, Scott I, Milner, Joshua D, Maverakis, Emanual, Miller, Lloyd S

“…The mechanisms that mediate durable protection against Staphylococcus aureus skin reinfections are unclear, as recurrences are common despite high antibody…”
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Mouse model of hematogenous implant-related Staphylococcus aureus biofilm infection reveals therapeutic targets by Wang, Yu, Cheng, Lily I., Helfer, David R., Ashbaugh, Alyssa G., Miller, Robert J., Tzomides, Alexander J., Thompson, John M., Ortines, Roger V., Tsai, Andrew S., Liu, Haiyun, Dillen, Carly A., Archer, Nathan K., Cohen, Taylor S., Tkaczyk, Christine, Stover, C. Kendall, Sellman, Bret R., Miller, Lloyd S.

“…Infection is a major complication of implantable medical devices, which provide a scaffold for biofilm formation, thereby reducing susceptibility to…”
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Theranostic biocomposite scaffold membrane by Roussakis, Emmanuel, Ortines, Roger V., Pinsker, Bret L., Mooers, Cavin T., Evans, Conor L., Miller, Lloyd S., Calderón-Colón, Xiomara

“…Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from…”
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Oral-Only Linezolid-Rifampin Is Highly Effective Compared with Other Antibiotics for Periprosthetic Joint Infection: Study of a Mouse Model by Thompson, John M., Saini, Vikram, Ashbaugh, Alyssa G., Miller, Robert J., Ordonez, Alvaro A., Ortines, Roger V., Wang, Yu, Sterling, Robert S., Jain, Sanjay K., Miller, Lloyd S.

“…The medical treatment of periprosthetic joint infection (PJI) involves prolonged systemic antibiotic courses, often with suboptimal clinical outcomes including…”
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Pan-caspase inhibition as a potential host-directed immunotherapy against MRSA and other bacterial skin infections by Alphonse, Martin P, Rubens, Jessica H, Ortines, Roger V, Orlando, Nicholas A, Patel, Aman M, Dikeman, Dustin, Wang, Yu, Vuong, Ivan, Joyce, Daniel P, Zhang, Jeffrey, Mumtaz, Mohammed, Liu, Haiyun, Liu, Qi, Youn, Christine, Patrick, Garrett J, Ravipati, Advaitaa, Miller, Robert J, Archer, Nathan K, Miller, Lloyd S

“…causes most skin infections in humans, and the emergence of methicillin-resistant (MRSA) strains is a serious public health threat. There is an urgent clinical…”
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CCR2 contributes to host defense against Staphylococcus aureus orthopedic implant‐associated infections in mice by Wang, Yu, Dikeman, Dustin, Zhang, Jeffrey, Ackerman, Nicole, Kim, Sophia, Alphonse, Martin P., Ortines, Roger V., Liu, Haiyun, Joyce, Daniel P., Dillen, Carly A., Thompson, John M., Thomas, Abigail A., Plaut, Roger D., Miller, Lloyd S., Archer, Nathan K.

“…C‐C motif chemokine receptor 2 (CCR2) is an important mediator of myeloid cell chemotaxis during inflammation and infection. Myeloid cells such as monocytes,…”
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Interleukin‐1β and tumor necrosis factor are essential in controlling an experimental orthopedic implant‐associated infection by Wang, Yu, Ashbaugh, Alyssa G., Dikeman, Dustin A., Zhang, Jeffrey, Ackerman, Nicole E., Kim, Sophie E., Falgons, Christian, Ortines, Roger V., Liu, Haiyun, Joyce, Daniel P., Alphonse, Martin Prince, Dillen, Carly A., Thompson, John M., Archer, Nathan K., Miller, Lloyd S.

“…Orthopedic implant‐associated infection (OIAI) is a major complication that leads to implant failure. In preclinical models of Staphylococcus aureus OIAI,…”
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In Vivo Bioluminescence Imaging in a Rabbit Model of Orthopaedic Implant-Associated Infection to Monitor Efficacy of an Antibiotic-Releasing Coating by Miller, Robert J., Thompson, John M., Zheng, Jesse, Marchitto, Mark C., Archer, Nathan K., Pinsker, Bret L., Ortines, Roger V., Jiang, Xuesong, Martin, Russell A., Brown, Isabelle D., Wang, Yu, Sterling, Robert S., Mao, Hai-Quan, Miller, Lloyd S.

“…In vivo bioluminescence imaging (BLI) provides noninvasive monitoring of bacterial burden in animal models of orthopaedic implant-associated infection (OIAI)…”
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Development of a Staphylococcus aureus reporter strain with click beetle red luciferase for enhanced in vivo imaging of experimental bacteremia and mixed infections by Miller, Robert J., Crosby, Heidi A., Schilcher, Katrin, Wang, Yu, Ortines, Roger V., Mazhar, Momina, Dikeman, Dustin A., Pinsker, Bret L., Brown, Isabelle D., Joyce, Daniel P., Zhang, Jeffrey, Archer, Nathan K., Liu, Haiyun, Alphonse, Martin P., Czupryna, Julie, Anderson, William R., Bernthal, Nicholas M., Fortuno-Miranda, Lea, Bulte, Jeff W. M., Francis, Kevin P., Horswill, Alexander R., Miller, Lloyd S.

“…In vivo bioluminescence imaging has been used to monitor Staphylococcus aureus infections in preclinical models by employing bacterial reporter strains…”
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Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice by Ortines, Roger V, Wang, Yu, Liu, Haiyun, Dikeman, Dustin A, Pinsker, Bret L, Miller, Robert J, Kim, Sophia E, Ackerman, Nicole E, Rizkallah, Joe F, Marcello, LeeAnn T, Cohen, Taylor S, Tkaczyk, Christine, Sellman, Bret R, Miller, Lloyd S

“…Surgical site infections (SSIs) are commonly caused by We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize alpha-toxin,…”
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