Search Results - "Orth, Anthony P."

SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel by Qiu, Zhaozhu, Dubin, Adrienne E, Mathur, Jayanti, Tu, Buu, Reddy, Kritika, Miraglia, Loren J, Reinhardt, Jürgen, Orth, Anthony P, Patapoutian, Ardem

“…Maintenance of a constant cell volume in response to extracellular or intracellular osmotic changes is critical for cellular homeostasis. Activation of a…”
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Co-regulatory networks of human serum proteins link genetics to disease by Emilsson, Valur, Ilkov, Marjan, Lamb, John R, Finkel, Nancy, Gudmundsson, Elias F, Pitts, Rebecca, Hoover, Heather, Gudmundsdottir, Valborg, Horman, Shane R, Aspelund, Thor, Shu, Le, Trifonov, Vladimir, Sigurdsson, Sigurdur, Manolescu, Andrei, Zhu, Jun, Olafsson, Örn, Jakobsdottir, Johanna, Lesley, Scott A, To, Jeremy, Zhang, Jia, Harris, Tamara B, Launer, Lenore J, Zhang, Bin, Eiriksdottir, Gudny, Yang, Xia, Orth, Anthony P, Jennings, Lori L, Gudnason, Vilmundur

“…Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end,…”
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Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets by Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.

“…A high-throughput RNA interference (RNAi) screen targeting 542 genes of the human kinome was used to discover regulators of RNAi. Here we report that the…”
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Proteomic associations with forced expiratory volume: a Mendelian randomisation study by Axelsson, Gisli Thor, Jonmundsson, Thorarinn, Woo, Youngjae, Frick, Elisabet Alexandra, Aspelund, Thor, Loureiro, Joseph J, Orth, Anthony P, Jennings, Lori L, Gudmundsson, Gunnar, Emilsson, Valur, Gudmundsdottir, Valborg, Gudnason, Vilmundur

“…A decline in forced expiratory volume (FEV1) is a hallmark of respiratory diseases that are an important cause of morbidity among the elderly. While some data…”
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Functional profiling of microtumors to identify cancer associated fibroblast-derived drug targets by Horman, Shane R, To, Jeremy, Lamb, John, Zoll, Jocelyn H, Leonetti, Nicole, Tu, Buu, Moran, Rita, Newlin, Robbin, Walker, John R, Orth, Anthony P

“…Recent advances in chemotherapeutics highlight the importance of molecularly-targeted perturbagens. Although these therapies typically address dysregulated…”
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Tumor suppressor protein (p)53, is a regulator of NF-κB repression by the glucocorticoid receptor by Murphy, Samantha H, Suzuki, Kotaro, Downes, Michael, Welch, Genevieve L, De Jesus, Paul, Miraglia, Loren J, Orth, Anthony P, Chanda, Sumit K, Evans, Ronald M, Verma, Inder M

“…Glucocorticoids can inhibit inflammation by abrogating the activity of NF-κB, a family of transcription factors that regulates the production of…”
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Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening by Zhou, Zongxiang, Patel, Manishha, Ng, Nicholas, Hsieh, Mindy H, Orth, Anthony P, Walker, John R, Batalov, Serge, Harris, Jennifer L, Liu, Jun

“…MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC in cancer has been challenging…”
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An HTS-compatible 3D colony formation assay to identify tumor-specific chemotherapeutics by Horman, Shane R, To, Jeremy, Orth, Anthony P

“…There has been increasing interest in the development of cellular behavior models that take advantage of three-dimensional (3D) cell culture. To enable…”
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Large-Scale Analysis of the Human and Mouse Transcriptomes by Su, Andrew I., Cooke, Michael P., Ching, Keith A., Hakak, Yaron, Walker, John R., Wiltshire, Tim, Orth, Anthony P., Vega, Raquel G., Sapinoso, Lisa M., Moqrich, Aziz, Patapoutian, Ardem, Hampton, Garret M., Schultz, Peter G., Hogenesch, John B.

“…High-throughput gene expression profiling has become an important tool for investigating transcriptional activity in a variety of biological samples. To date,…”
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FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells by Kim, Sungeun, Dubrovska, Anna, Salamone, Richard J, Walker, John R, Grandinetti, Kathryn B, Bonamy, Ghislain M C, Orth, Anthony P, Elliott, Jimmy, Porta, Diana Graus, Garcia-Echeverria, Carlos, Reddy, Venkateshwar A

“…Emerging evidence suggests that some cancers contain a population of stem-like TICs (tumor-initiating cells) and eliminating TICs may offer a new strategy to…”
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High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor by Groot-Kormelink, Paul J, Ferrand, Sandrine, Kelley, Nicholas, Bill, Anke, Freuler, Felix, Imbert, Pierre-Eloi, Marelli, Anthony, Gerwin, Nicole, Sivilotti, Lucia G, Miraglia, Loren, Orth, Anthony P, Oakeley, Edward J, Schopfer, Ulrich, Siehler, Sandra

“…High throughput random mutagenesis is a powerful tool to identify which residues are important for the function of a protein, and gain insight into its…”
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Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen by Hu, Xiaoyi V., Rodrigues, Tânia M. A., Tao, Haiyan, Baker, Robert K., Miraglia, Loren, Orth, Anthony P., Lyons, Gary E., Schultz, Peter G., Wu, Xu

“…DNA methylation is an important epigenetic modification involved in transcriptional regulation, nuclear organization, development, aging, and disease. Although…”
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Screening the Mammalian Extracellular Proteome for Regulators of Embryonic Human Stem Cell Pluripotency by Gonzalez, Rodolfo, Jennings, Lori L., Knuth, Mark, Orth, Anthony P., Klock, Heath E., Ou, Weija, Feuerhelm, Julie, Hull, Mitchell V., Koesema, Eric, Wang, Yuping, Zhang, Jia, Wu, Chunlei, Cho, Charles Y., Su, Andrew I., Batalov, Serge, Chen, Hong, Johnson, Kristen, Laffitte, Bryan, Nguyerf, Deborah G., Snyder, Evan Y., Schult, Peter G., Harris, Jennifer L., Lesley, Scott A.

“…Approximately 3,500 mammalian genes are predicted to be secreted or single-pass transmembrane proteins. The function of the majority of these genes is still…”
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Identification of a Family of cAMP Response Element-Binding Protein Coactivators by Genome-Scale Functional Analysis in Mammalian Cells by Iourgenko, Vadim, Zhang, Wenjun, Mickanin, Craig, Daly, Ira, Jiang, Can, Hexham, Jonathan M., Orth, Anthony P., Miraglia, Loren, Meltzer, Jodi, Garza, Dan, Chirn, Gung-Wei, McWhinnie, Elizabeth, Cohen, Dalia, Skelton, Joanne, Terry, Robert, Yu, Yang, Bodian, Dale, Buxton, Frank P., Zhu, Jian, Song, Chuanzheng, Labow, Mark A.

“…This report describes an unbiased method for systematically determining gene function in mammalian cells. A total of 20,704 predicted human full-length cDNAs…”
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coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway by Amelio, Antonio L, Miraglia, Loren J, Conkright, Juliana J, Mercer, Becky A, Batalov, Serge, Cavett, Valerie, Orth, Anthony P, Busby, Jennifer, Hogenesch, John B, Conkright, Michael D

“…Signal transduction pathways often use a transcriptional component to mediate adaptive cellular responses. Coactivator proteins function prominently in these…”
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Genome-Wide Functional Analysis of Human Cell-Cycle Regulators by Mukherji, Mridul, Bell, Russell, Supekova, Lubica, Wang, Yan, Orth, Anthony P., Batalov, Serge, Miraglia, Loren, Huesken, Dieter, Lange, Joerg, Martin, Christopher, Sahasrabudhe, Sudhir, Reinhardt, Mischa, Natt, Francois, Hall, Jonathan, Mickanin, Craig, Labow, Mark, Chanda, Sumit K., Cho, Charles Y., Schultz, Peter G.

“…Human cells have evolved complex signaling networks to coordinate the cell cycle. A detailed understanding of the global regulation of this fundamental process…”
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A functional genomics approach to the mode of action of apratoxin A by Izpisúa Belmonte, Juan Carlos, Luesch, Hendrik, Orth, Anthony P, DeJesus, Paul D, Raya, R Marina, Walker, John R, Schultz, Peter G, Chanda, Sumit K

“…The cyanobacterial metabolite apratoxin A (1) demonstrates potent cytotoxicity against tumor cell lines by a hitherto unknown mechanism. We have used…”
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Cofactors Required for TLR7- and TLR9-Dependent Innate Immune Responses by Chiang, Chih-yuan, Engel, Alex, Opaluch, Amanda M., Ramos, Irene, Maestre, Ana M., Secundino, Ismael, De Jesus, Paul D., Nguyen, Quy T., Welch, Genevieve, Bonamy, Ghislain M.C., Miraglia, Loren J., Orth, Anthony P., Nizet, Victor, Fernandez-Sesma, Ana, Zhou, Yingyao, Barton, Gregory M., Chanda, Sumit K.

“…Pathogens commonly utilize endocytic pathways to gain cellular access. The endosomal pattern recognition receptors TLR7 and TLR9 detect pathogen-encoded…”
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Gene set enrichment in eQTL data identifies novel annotations and pathway regulators by Wu, Chunlei, Delano, David L, Mitro, Nico, Su, Stephen V, Janes, Jeff, McClurg, Phillip, Batalov, Serge, Welch, Genevieve L, Zhang, Jie, Orth, Anthony P, Walker, John R, Glynne, Richard J, Cooke, Michael P, Takahashi, Joseph S, Shimomura, Kazuhiro, Kohsaka, Akira, Bass, Joseph, Saez, Enrique, Wiltshire, Tim, Su, Andrew I

“…Genome-wide gene expression profiling has been extensively used to generate biological hypotheses based on differential expression. Recently, many studies have…”
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EndoBind detects endogenous protein-protein interactions in real time by Bill, Anke, Espinola, Sheryll, Guthy, Daniel, Haling, Jacob R., Lanter, Mylene, Lu, Min, Marelli, Anthony, Mendiola, Angelica, Miraglia, Loren, Taylor, Brandon L., Vargas, Leonardo, Orth, Anthony P., King, Frederick J.

“…We present two high-throughput compatible methods to detect the interaction of ectopically expressed (RT-Bind) or endogenously tagged (EndoBind) proteins of…”
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