Search Results - "Ortego, Lisa S"

Scientific integrity issues in Environmental Toxicology and Chemistry: Improving research reproducibility, credibility, and transparency by Mebane, Christopher A, Sumpter, John P, Fairbrother, Anne, Augspurger, Thomas P, Canfield, Timothy J, Goodfellow, William L, Guiney, Patrick D, LeHuray, Anne, Maltby, Lorraine, Mayfield, David B, McLaughlin, Michael J, Ortego, Lisa S, Schlekat, Tamar, Scroggins, Richard P, Verslycke, Tim A

“…ABSTRACT High‐profile reports of detrimental scientific practices leading to retractions in the scientific literature contribute to lack of trust in scientific…”
Get full text

Current testing programs for pesticides adequately capture endocrine activity and adversity for protection of vertebrate wildlife by Staveley, Jane P., Freeman, Elaine L., McArdle, Margaret E., Ortego, Lisa S., Coady, Katherine K., Bone, Audrey, Lagadic, Laurent, Weltje, Lennart, Weyers, Arnd, Wheeler, James R.

“…The toxicity and ecotoxicity of pesticide active ingredients are evaluated by a number of standardized test methods using vertebrate animals. These standard…”
Get full text

Sources of variability in plant toxicity testing by Clark, Jeremy, Ortego, Lisa S., Fairbrother, Anne

“…Published literature is investigated regarding the response of plants to various substances to determine the sensitivity of agricultural plants versus other…”
Get full text

Critical Review of Read‐Across Potential in Testing for Endocrine‐Related Effects in Vertebrate Ecological Receptors by McArdle, Margaret E., Freeman, Elaine L., Staveley, Jane P., Ortego, Lisa S., Coady, Katherine K., Weltje, Lennart, Weyers, Arnd, Wheeler, James R., Bone, Audrey J.

“…Recent regulatory testing programs have been designed to evaluate whether a chemical has the potential to interact with the endocrine system and could cause…”
Get full text

The Extended Amphibian Metamorphosis Assay: A Thyroid‐Specific and Less Animal‐Intensive Alternative to the Larval Amphibian Growth and Development Assay by Ortego, Lisa S., Olmstead, Allen W., Weltje, Lennart, Wheeler, James R., Bone, Audrey J., Coady, Katherine K., Banman, Chris S., Burden, Natalie, Lagadic, Laurent

“…The amphibian metamorphosis assay (AMA; US Environmental Protection Agency [USEPA] test guideline 890.1100 and Organisation for Economic Co‐Operation and…”
Get full text

Essentiality of nickel and homeostatic mechanisms for its regulation in terrestrial organisms by Phipps, T, Tank, S L, Wirtz, J, Brewer, L, Coyner, A, Ortego, L S, Fairbrother, A

“…Nickel (Ni) is a naturally occurring element with many industrial uses, including in stainless steel, electroplating, pigments, and ceramics. Consequently, Ni…”
Get full text

Acute and chronic toxicity testing of bisphenol A with aquatic invertebrates and plants by Mihaich, Ellen M., Friederich, Urs, Caspers, Norbert, Hall, A. Tilghman, Klecka, Gary M., Dimond, Stephen S., Staples, Charles A., Ortego, Lisa S., Hentges, Steven G.

“…Bisphenol A (BPA, 4,4′-isopropylidine diphenol) is a commercially important chemical used primarily as an intermediate in the production of polycarbonate…”
Get full text

Hypothesis-driven weight of evidence framework for evaluating data within the US EPA’s Endocrine Disruptor Screening Program by Borgert, Christopher J., Mihaich, Ellen M., Ortego, Lisa S., Bentley, Karin S., Holmes, Catherine M., Levine, Steven L., Becker, Richard A.

“…► A framework was developed for weight of evidence evaluations of endocrine activity. ► The framework is tailored to the US EPA’s Endocrine Disruptor Screening…”
Get full text

Relevance Weighting of Tier 1 Endocrine Screening Endpoints by Rank Order by Borgert, Christopher J., Stuchal, Leah D., Mihaich, Ellen M., Becker, Richard A., Bentley, Karin S., Brausch, John M., Coady, Katie, Geter, David R., Gordon, Elliot, Guiney, Patrick D., Hess, Frederick, Holmes, Catherine M., LeBaron, Matthew J., Levine, Steve, Marty, Sue, Mukhi, Sandeep, Neal, Barbara H., Ortego, Lisa S., Saltmiras, David A., Snajdr, Suzanne, Staveley, Jane, Tobia, Abraham

“…Weight of evidence (WoE) approaches are recommended for interpreting various toxicological data, but few systematic and transparent procedures exist. A…”
Get full text

Lessons learned, challenges, and opportunities: the U.S. Endocrine Disruptor Screening Program by Juberg, Daland R, Borghoff, Susan J, Becker, Richard A, Casey, Warren, Hartung, Thomas, Holsapple, Michael P, Marty, M Sue, Mihaich, Ellen M, Van Der Kraak, Glen, Wade, Michael G, Willett, Catherine E, Andersen, Melvin E, Borgert, Christopher J, Coady, Katherine K, Dourson, Michael L, Fowle, 3rd, John R, Gray, L Earl, Lamb, James C, Ortego, Lisa S, Schug, Thaddeus T, Toole, Colleen M, Zorrilla, Leah M, Kroner, Oliver L, Patterson, Jacqueline, Rinckel, Lori A, Jones, Brett R

“…In 1996, the U.S. Congress passed the Food Quality Protection Act and amended the Safe Drinking Water Act (SDWA) requiring the U.S. Environmental Protection…”
Get full text

Long-Term Primary Culture of Epithelial Cells from Rainbow Trout (Oncorhynchus Mykiss) Liver by Ostrander, Gary K., James B. Blair, Beverly A. Stark, Garry M. Marley, Wesley D. Bales, Robert W. Veltri, Hinton, David E., Mark Okihiro, Lisa S. Ortego, Hawkins, William E.

“…Long-term primary cultures of epithelial cells from rainbow trout (Oncorhynchus mykiss) liver have been established. Nearly homogenous (>97%) populations of…”
Get full text

Immunohistochemical detection of proliferating cell nuclear antigen (PCNA) in tissues of aquatic animals utilized in toxicity bioassays by Ortego, Lisa S., Hawkins, William E., Walker, William W., Krol, Rena M., Benson, William H.

“…Cell proliferation is an important component of toxic and carcinogenic mechanisms. A recently developed immunohistochemical assay for proliferating cell…”
Get full text

Cell proliferation in normal and neoplastic tissues of three fish species: Comparison of bromodeoxyuridine and proliferating cell nuclear antigen immunohistochemistry by Ortego, Lisa S., Moore, Michael J., Myers, Mark S., Vogelbein, Wolfgang K., Stegeman, John J., Hawkins, William E.

“…Determination of cell proliferation in aquatic organisms from laboratory and field studies could aid in investigating toxic and carcinogenic processes. Several…”
Get full text

Early life-stage effects in medaka (Oryzias latipes) following in ovo exposure to polyamine biosynthetic inhibitors by Ortego, L S, Nimrod, A C, Brehm, W T, Parsons, G R, Benson, W H

“…Medaka, Oryzias latipes, were exposed in ovo to the polyamine (PA) biosynthesis inhibitors alpha-difluoromethylornithine (DFMO) and methylglyoxal…”
Get more information

Immunohistochemical detection of P-glycoprotein in teleost tissues using mammalian polyclonal and monoclonal antibodies by Hemmer, M J, Courtney, L A, Ortego, L S

“…Mammalian P-glycoprotein is a highly conserved 170-kD integral plasma membrane protein functioning as an energy-dependent efflux pump of exogenous and…”
Get more information