Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico

Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico

Metabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas. In a cross-sectional stu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of physiological anthropology Vol. 40; no. 1; pp. 1 - 11
Main Authors: Ortega, Pilar E. Núéez, Meneses, María E, Delgado-Enciso, Iván, Irecta-Nájera, César Antonio, Castro-Quezada, Itandehui, Solís-Hernández, Roberto, Flores-Guillén, Elena, García-Miranda, Rosario, Valladares-Salgado, Adán, Locia-Morales, Daniel, Ochoa-Díaz-López, Héctor
Format: Journal Article
Language:English
Published: Tokyo BioMed Central Ltd 28-08-2021
BioMed Central
BMC
Subjects:
Analysis
Blood pressure
Body mass index
Chiapas
Diabetes
Family medical history
Fasting
Food
FTO
Gene frequency
Gene polymorphism
Genetic testing
Glucose
Hyperglycemia
Hypertension
Indigenous peoples
Insulin resistance
Mayan indigenous women
Metabolic syndrome
Mexico
Mortality
Obesity
Original
Overweight
Population
Questionnaires
Regression analysis
Risk factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Sociodemographics
Statistical analysis
Triglycerides
Type 2 diabetes
Women
Womens health
Mexico
Germany
France
United States > US
Berlin Germany
Japan
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas. In a cross-sectional study, sociodemographic, anthropometric, clinical, and biochemical data were obtained from 291 adult women from three regions of Chiapas, Mexico. The prevalence of MetS and the allele and genotype frequencies of the rs9939609-FTO were estimated. Multivariate logistic regression models were used to assess the association of the single nucleotide polymorphism (SNP) with each of the MetS components. The MetS prevalence was 60%. We found a statistically significant association between rs9939609-FTO and hyperglycemia in the dominant model (OR 2.6; 95% CI 1.3-5.3; p = 0.007). Women from Mayan communities of Chiapas presented a high prevalence of MetS and a relevant association of the FTO variant with hyperglycemia. This is the first study carried out in these Mayan indigenous communities from Chiapas.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1880-6805
1880-6791
1880-6805
DOI:10.1186/s40101-021-00259-9