Search Results - "Ortega, David Gallego"

Genomic Cytometry Editorial by Salomon, Robert, Gallego‐Ortega, David

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Mammary Tumor Organoid Culture in Non‐Adhesive Alginate for Luminal Mechanics and High‐Throughput Drug Screening by Fang, Guocheng, Lu, Hongxu, Rodriguez de la Fuente, Laura, Law, Andrew M. K., Lin, Gungun, Jin, Dayong, Gallego‐Ortega, David

“…Mammary tumor organoids have become a promising in vitro model for drug screening and personalized medicine. However, the dependency on the basement membrane…”
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Genomic Cytometry and New Modalities for Deep Single‐Cell Interrogation by Salomon, Robert, Martelotto, Luciano, Valdes‐Mora, Fatima, Gallego‐Ortega, David

“…In the past few years, the rapid development of single‐cell analysis techniques has allowed for increasingly in‐depth analysis of DNA, RNA, protein, and…”
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Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells by Chua, Boon Tin, Gallego-Ortega, David, Ramirez de Molina, Ana, Ullrich, Axel, Lacal, Juan Carlos, Downward, Julian

“…The serine/threonine kinase PKB/Akt plays essential role in various cellular processes including cell growth and proliferation, metabolism and cell survival…”
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Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer by Law, Andrew M K, Valdes-Mora, Fatima, Gallego-Ortega, David

“…The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and…”
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ALTEN: A High‐Fidelity Primary Tissue‐Engineering Platform to Assess Cellular Responses Ex Vivo by Law, Andrew M. K., Chen, Jiamin, Colino‐Sanguino, Yolanda, Fuente, Laura Rodriguez de la, Fang, Guocheng, Grimes, Susan M., Lu, Hongxu, Huang, Robert J., Boyle, Sarah T., Venhuizen, Jeron, Castillo, Lesley, Tavakoli, Javad, Skhinas, Joanna N., Millar, Ewan K. A., Beretov, Julia, Rossello, Fernando J., Tipper, Joanne L., Ormandy, Christopher J., Samuel, Michael S., Cox, Thomas R., Martelotto, Luciano, Jin, Dayong, Valdes‐Mora, Fatima, Ji, Hanlee P., Gallego‐Ortega, David

“…To fully investigate cellular responses to stimuli and perturbations within tissues, it is essential to replicate the complex molecular interactions within the…”
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Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis by Papanicolaou, Michael, Parker, Amelia L., Yam, Michelle, Filipe, Elysse C., Wu, Sunny Z., Chitty, Jessica L., Wyllie, Kaitlin, Tran, Emmi, Mok, Ellie, Nadalini, Audrey, Skhinas, Joanna N., Lucas, Morghan C., Herrmann, David, Nobis, Max, Pereira, Brooke A., Law, Andrew M. K., Castillo, Lesley, Murphy, Kendelle J., Zaratzian, Anaiis, Hastings, Jordan F., Croucher, David R., Lim, Elgene, Oliver, Brian G., Mora, Fatima Valdes, Parker, Benjamin L., Gallego-Ortega, David, Swarbrick, Alexander, O’Toole, Sandra, Timpson, Paul, Cox, Thomas R.

“…The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in shaping their…”
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Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization by Mayer, Johannes U., Hilligan, Kerry L., Chandler, Jodie S., Eccles, David A., Old, Samuel I., Domingues, Rita G., Yang, Jianping, Webb, Greta R., Munoz-Erazo, Luis, Hyde, Evelyn J., Wakelin, Kirsty A., Tang, Shiau-Choot, Chappell, Sally C., von Daake, Sventja, Brombacher, Frank, Mackay, Charles R., Sher, Alan, Tussiwand, Roxane, Connor, Lisa M., Gallego-Ortega, David, Jankovic, Dragana, Le Gros, Graham, Hepworth, Matthew R., Lamiable, Olivier, Ronchese, Franca

“…The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of…”
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Disentangling single-cell omics representation with a power spectral density-based feature extraction by Zandavi, Seid Miad, Koch, Forrest C, Vijayan, Abhishek, Zanini, Fabio, Mora, Fatima Valdes, Ortega, David Gallego, Vafaee, Fatemeh

“…Abstract Emerging single-cell technologies provide high-resolution measurements of distinct cellular modalities opening new avenues for generating detailed…”
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Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies by Law, Andrew M K, Rodriguez de la Fuente, Laura, Grundy, Thomas J, Fang, Guocheng, Valdes-Mora, Fatima, Gallego-Ortega, David

“…Over 90% of potential anti-cancer drug candidates results in translational failures in clinical trials. The main reason for this failure can be attributed to…”
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Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment by Araujo, Angela M, Abaurrea, Andrea, Azcoaga, Peio, López-Velazco, Joanna I, Manzano, Sara, Rodriguez, Javier, Rezola, Ricardo, Egia-Mendikute, Leire, Valdés-Mora, Fátima, Flores, Juana M, Jenkins, Liam, Pulido, Laura, Osorio-Querejeta, Iñaki, Fernández-Nogueira, Patricia, Ferrari, Nicola, Viera, Cristina, Martín-Martín, Natalia, Tzankov, Alexandar, Eppenberger-Castori, Serenella, Alvarez-Lopez, Isabel, Urruticoechea, Ander, Bragado, Paloma, Coleman, Nicholas, Palazón, Asís, Carracedo, Arkaitz, Gallego-Ortega, David, Calvo, Fernando, Isacke, Clare M, Caffarel, María M, Lawrie, Charles H

“…The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the…”
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Cell Lineage Tracing Identifies Hormone-Regulated and Wnt-Responsive Vaginal Epithelial Stem Cells by Ali, Ayesha, Syed, Shafiq M., Jamaluddin, M. Fairuz B., Colino-Sanguino, Yolanda, Gallego-Ortega, David, Tanwar, Pradeep S.

“…The intact vaginal epithelium is essential for women’s reproductive health and provides protection against HIV and sexually transmitted infections. How this…”
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ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling by Pinho, Andreia V., Van Bulck, Mathias, Chantrill, Lorraine, Arshi, Mehreen, Sklyarova, Tatyana, Herrmann, David, Vennin, Claire, Gallego-Ortega, David, Mawson, Amanda, Giry-Laterriere, Marc, Magenau, Astrid, Leuckx, Gunther, Baeyens, Luc, Gill, Anthony J., Phillips, Phoebe, Timpson, Paul, Biankin, Andrew V., Wu, Jianmin, Rooman, Ilse

“…Whereas genomic aberrations in the SLIT-ROBO pathway are frequent in pancreatic ductal adenocarcinoma (PDAC), their function in the pancreas is unclear. Here…”
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Advancements and challenges in developing in vivo CAR T cell therapies for cancer treatment by Bui, Thuy Anh, Mei, Haoqi, Sang, Rui, Ortega, David Gallego, Deng, Wei

“…The Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a ground-breaking immunotherapeutic approach in cancer treatment. To overcome the complexity…”
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Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer by Valdés-Mora, Fátima, Gould, Cathryn M., Colino-Sanguino, Yolanda, Qu, Wenjia, Song, Jenny Z., Taylor, Kylie M., Buske, Fabian A., Statham, Aaron L., Nair, Shalima S., Armstrong, Nicola J., Kench, James G., Lee, Kenneth M. L., Horvath, Lisa G., Qiu, Minru, Ilinykh, Alexei, Yeo-Teh, Nicole S., Gallego-Ortega, David, Stirzaker, Clare, Clark, Susan J.

“…Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active promoters and is associated with oncogene activation in prostate cancer, but its role in…”
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Single-Cell Transcriptomics in Cancer Immunobiology: The Future of Precision Oncology by Valdes-Mora, Fatima, Handler, Kristina, Law, Andrew M K, Salomon, Robert, Oakes, Samantha R, Ormandy, Christopher J, Gallego-Ortega, David

“…Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a myriad of non-cancerous cell types that together with the extracellular…”
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Static droplet array for culturing single live adherent cells in an isolated chemical microenvironment by Hassanzadeh-Barforoushi, Amin, Law, Andrew M K, Hejri, Abbas, Asadnia, Mohsen, Ormandy, Christopher J, Gallego-Ortega, David, Ebrahimi Warkiani, Majid

“…We present here a new method to easily and reliably generate an array of hundreds of dispersed nanoliter-volume semi-droplets for single-cells culture and…”
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Upconversion nanoparticle‐assisted single‐molecule assay for detecting circulating antigens of aggressive prostate cancer by Chen, Yinghui, Shimoni, Olga, Huang, Guan, Wen, Shihui, Liao, Jiayan, Duong, Hien T. T., Maddahfar, Mahnaz, Su, Qian Peter, Ortega, David Gallego, Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J., Jin, Dayong

“…Sensitive and quantitative detection of molecular biomarkers is crucial for the early diagnosis of diseases like metabolic syndrome and cancer. Here we present…”
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Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype by Valdés-Mora, Fátima, Salomon, Robert, Gloss, Brian Stewart, Law, Andrew Man Kit, Venhuizen, Jeron, Castillo, Lesley, Murphy, Kendelle Joan, Magenau, Astrid, Papanicolaou, Michael, Rodriguez de la Fuente, Laura, Roden, Daniel Lee, Colino-Sanguino, Yolanda, Kikhtyak, Zoya, Farbehi, Nona, Conway, James Ronald William, Sikta, Neblina, Oakes, Samantha Richelle, Cox, Thomas Robert, O’Donoghue, Seán Ignatius, Timpson, Paul, Ormandy, Christopher John, Gallego-Ortega, David

“…Basal breast cancer is associated with younger age, early relapse, and a high mortality rate. Here, we use unbiased droplet-based single-cell RNA sequencing…”
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Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment by Araujo, Angela M, Abaurrea, Andrea, Azcoaga, Peio, López-Velazco, Joanna I, Manzano, Sara, Rodriguez, Javier, Rezola, Ricardo, Egia-Mendikute, Leire, Valdés-Mora, Fátima, Flores, Juana M, Jenkins, Liam, Pulido, Laura, Osorio-Querejeta, Iñaki, Fernández-Nogueira, Patricia, Ferrari, Nicola, Viera, Cristina, Martín-Martín, Natalia, Tzankov, Alexandar, Eppenberger-Castori, Serenella, Alvarez-Lopez, Isabel, Urruticoechea, Ander, Bragado, Paloma, Coleman, Nicholas, Palazón, Asís, Carracedo, Arkaitz, Gallego-Ortega, David, Calvo, Fernando, Isacke, Clare M, Caffarel, María M, Lawrie, Charles H

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