Search Results - "Orta, Manuel Luis"

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair by Petermann, Eva, Orta, Manuel Luís, Issaeva, Natalia, Schultz, Niklas, Helleday, Thomas

“…Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs, which initially results in stalled replication forks that,…”
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Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors by Hajji, Nabil, Garcia-Revilla, Juan, Soto, Manuel Sarmiento, Perryman, Richard, Symington, Jake, Quarles, Chad C, Healey, Deborah R, Guo, Yijie, Orta-Vázquez, Manuel Luis, Mateos-Cordero, Santiago, Shah, Khalid, Bomalaski, John, Anichini, Giulio, Tzakos, Andreas G, Crook, Timothy, O'Neill, Kevin, Scheck, Adrienne C, Venero, Jose Luis, Syed, Nelofer

“…New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is…”
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Evaluating the Cancer Therapeutic Potential of Cardiac Glycosides by Burgos-Morón, Estefanía, Calderón-Montaño, José Manuel, Orta, Manuel Luis, Maldonado-Navas, Dolores, García-Domínguez, Irene, López-Lázaro, Miguel

“…Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring…”
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Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA damage, formation of topoisomerase I- and II-DNA complexes and cancer cell death by Calderón-Montaño, José Manuel, Burgos-Morón, Estefanía, Orta, Manuel Luis, Pastor, Nuria, Austin, Caroline A., Mateos, Santiago, López-Lázaro, Miguel

“…•Numerous naturally occurring compounds contain the lactones 2-furanone and 2-pyrone.•We report that 2-furanone and 2-pyrone induce cellular DNA damage.•Both…”
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Effect of DNA repair deficiencies on the cytotoxicity of drugs used in cancer therapy - a review by Calderón-Montaño, José Manuel, Burgos-Morón, Estefanía, Orta, Manuel Luis, López-Lázaro, Miguel

“…Tumor cells often have defects in DNA repair pathways that make them vulnerable to specific DNA-damaging anticancer agents. The identification of DNA repair…”
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Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid by Burgos-Morón, Estefanía, Calderón-Montaño, José Manuel, Orta, Manuel Luis, Guillén-Mancina, Emilio, Mateos, Santiago, López-Lázaro, Miguel

“…Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular disorders, some cancers, diabetes,…”
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DNA demethylation protects from cleavable complex stabilization and DNA strand breakage induced by the topoisomerase type I inhibitor camptothecin by Orta, Manuel Luís, Mateos, Santiago, Cortés, Felipe

“…Methylation of cytosine in CpG sequences of the DNA in mammalian cells is an epigenetic feature regulated very exactly that bears importance for events like…”
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Metabolic Disturbance of High-Saturated Fatty Acid Diet in Cognitive Preservation by Rivas-Domínguez, Antonio, Mohamed-Mohamed, Himan, Jimenez-Palomares, Margarita, García-Morales, Victoria, Martinez-Lopez, Laura, Orta, Manuel Luis, Ramos-Rodriguez, Juan José, Bermudez-Pulgarin, Beatriz

“…Aging continues to be the main cause of the development of Alzheimer's, although it has been described that certain chronic inflammatory pathologies can…”
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The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions by Orta, Manuel Luis, Höglund, Andreas, Calderón-Montaño, José Manuel, Domínguez, Inmaculada, Burgos-Morón, Estefanía, Visnes, Torkild, Pastor, Nuria, Ström, Cecilia, López-lázaro, Miguel, Helleday, Thomas

“…Decitabine (5-aza-2'-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid Leukemia (AML). Its mechanism of…”
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The Coffee Constituent Chlorogenic Acid Induces Cellular DNA Damage and Formation of Topoisomerase I– and II–DNA Complexes in Cells by Burgos-Morón, Estefanía, Calderón-Montaño, José Manuel, Orta, Manuel Luis, Pastor, Nuria, Pérez-Guerrero, Concepción, Austin, Caroline, Mateos, Santiago, López-Lázaro, Miguel

“…Chlorogenic acid (CGA) is a plant polyphenol with known antioxidant properties. Although some studies suggest that CGA has anticancer properties, others…”
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5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair by Orta, Manuel Luís, Calderón-Montaño, José Manuel, Domínguez, Inmaculada, Pastor, Nuria, Burgos-Morón, Estefanía, López-Lázaro, Miguel, Cortés, Felipe, Mateos, Santiago, Helleday, Thomas

“…5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological diseases and works by being…”
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The Role of DNA Damage Response in Dysbiosis-Induced Colorectal Cancer by Rivas-Domínguez, Antonio, Pastor, Nuria, Martínez-López, Laura, Colón-Pérez, Julia, Bermúdez, Beatriz, Orta, Manuel Luis

“…The high incidence of colorectal cancer (CRC) in developed countries indicates a predominant role of the environment as a causative factor. Natural gut…”
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A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells by Calderón-Montaño, José Manuel, Burgos-Morón, Estefanía, Orta, Manuel Luis, Mateos, Santiago, López-Lázaro, Miguel

“…Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium oleander has been used in traditional…”
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Selective Cytotoxic Activity of New Lipophilic Hydroxytyrosol Alkyl Ether Derivatives by Calderón-Montaño, José Manuel, Madrona, Andrés, Burgos-Morón, Estefanía, Orta, Manuel Luis, Mateos, Santiago, Espartero, José Luis, López-Lázaro, Miguel

“…Recent data suggest that hydroxytyrosol, a phenolic compound of virgin olive oils, has anticancer activity. This communication reports the synthesis of decyl…”
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Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation by Groth, Petra, Orta, Manuel Luís, Elvers, Ingegerd, Majumder, Muntasir Mamun, Lagerqvist, Anne, Helleday, Thomas

“…Ionizing radiation (IR) produces direct two-ended DNA double-strand breaks (DSBs) primarily repaired by non-homologous end joining (NHEJ). It is, however, well…”
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Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination by Orta, Manuel Luis, Pastor, Nuria, Burgos-Morón, Estefanía, Domínguez, Inmaculada, Calderón-Montaño, José Manuel, Huertas Castaño, Carlos, López-Lázaro, Miguel, Helleday, Thomas, Mateos, Santiago

“…•HR is the main pathway to repair DSB induced by zebularine.•Zebularine induces replicacion coupled-DSB that are repaired by HR through an exchange mechanism…”
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In Vitro Anticancer Activity and Mechanism of Action of an Aziridinyl Galactopyranoside by Burgos-Morón, Estefanía, Pastor, Nuria, Orta, Manuel Luis, Jiménez-Alonso, Julio José, Palo-Nieto, Carlos, Vega-Holm, Margarita, Vega-Pérez, José Manuel, Iglesias-Guerra, Fernando, Mateos, Santiago, López-Lázaro, Miguel, Calderón-Montaño, José Manuel

“…We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and identified 2-methyl-2,3-[…”
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Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside by Burgos‐Morón, Estefanía, Pastor, Nuria, Orta, Manuel Luis, Jiménez‐Alonso, Julio José, Vega‐Holm, Margarita, Vega‐Pérez, José Manuel, Iglesias‐Guerra, Fernando, Mateos, Santiago, López‐Lázaro, Miguel, Calderón‐Montaño, José Manuel

“…Preclinical Research & Development Several clinically useful anticancer drugs selectively kill cancer cells by inducing DNA damage; the genomic instability and…”
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The DNA topoisomerase II catalytic inhibitor merbarone is genotoxic and induces endoreduplication by Pastor, Nuria, Domínguez, Inmaculada, Orta, Manuel Luís, Campanella, Claudia, Mateos, Santiago, Cortés, Felipe

“…In the last years a number of reports have shown that the so-called topoisomerase II (topo II) catalytic inhibitors are able to induce DNA and chromosome…”
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Protection of halogenated DNA from strand breakage and sister-chromatid exchange induced by the topoisomerase I inhibitor camptothecin by Orta, Manuel Luís, Mateos, Santiago, Cantero, Gloria, Wolff, Lisa J, Cortés, Felipe

“…The fundamental nuclear enzyme DNA topoisomerase I (topo I), cleaves the double-stranded DNA molecule at preferred sequences within its recognition/binding…”
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