Search Results - "Orsulic, Sandra"

Inflammation is a key contributor to ovarian cancer cell seeding by Jia, Dongyu, Nagaoka, Yoshiko, Katsumata, Makoto, Orsulic, Sandra

“…The incidence of ovarian cancer dramatically increases in early menopause but the factors contributing to cancer onset are unclear. Most ovarian cancers…”
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Mouse models of cancer by Cheon, Dong-Joo, Orsulic, Sandra

“…Genetically engineered mouse models have significantly contributed to our understanding of cancer biology. They have proven to be useful in validating gene…”
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Response to the Letter to the Editor on : "A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets," Cancer Lett. 2016 Nov 28;382(2):203-214 by Orsulic, Sandra, Dr

“…Due to our focus on the pan-cancer gene signature of cancer-associated fibroblasts (CAFs) exclusively in primary cancers [2], we did not discuss multiple…”
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Editorial: Molecular pathology and computational image analyses in gynecologic malignancies by Malapelle, Umberto, Orsulic, Sandra

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Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment by Dinh, Huy Q., Pan, Feng, Wang, Geng, Huang, Qing-Feng, Olingy, Claire E., Wu, Zhi-Yong, Wang, Shao-Hong, Xu, Xin, Xu, Xiu-E, He, Jian-Zhong, Yang, Qian, Orsulic, Sandra, Haro, Marcela, Li, Li-Yan, Huang, Guo-Wei, Breunig, Joshua J., Koeffler, H. Phillip, Hedrick, Catherine C., Xu, Li-Yan, Lin, De-Chen, Li, En-Min

“…The tumor microenvironment is a highly complex ecosystem of diverse cell types, which shape cancer biology and impact the responsiveness to therapy. Here, we…”
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The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor by GASSER, Stephan, ORSULIC, Sandra, BROWN, Eric J, RAULET, David H

“…Some stimulatory receptors of the innate immune system, such as the NKG2D receptor (also called KLRK1) expressed by natural killer cells and activated CD8(+)T…”
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A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets by Jia, Dongyu, Liu, Zhenqiu, Deng, Nan, Tan, Tuan Zea, Huang, Ruby Yun-Ju, Taylor-Harding, Barbie, Cheon, Dong- Joo, Lawrenson, Kate, Wiedemeyer, Wolf R, Walts, Ann E, Karlan, Beth Y, Orsulic, Sandra

“…Highlights • COL11A1 is a highly specific biomarker of activated CAFs in multiple epithelial cancer types. • COL11A1 is not expressed in mesenchymal precursors…”
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Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer by Goode, Ellen L, Block, Matthew S, Kalli, Kimberly R, Vierkant, Robert A, Chen, Wenqian, Fogarty, Zachary C, Gentry-Maharaj, Aleksandra, Tołoczko, Aleksandra, Hein, Alexander, Bouligny, Aliecia L, Jensen, Allan, Osorio, Ana, Hartkopf, Andreas, Ryan, Andy, Chudecka-Głaz, Anita, Magliocco, Anthony M, Hartmann, Arndt, Jung, Audrey Y, Gao, Bo, Hernandez, Brenda Y, Fridley, Brooke L, McCauley, Bryan M, Kennedy, Catherine J, Wang, Chen, Karpinskyj, Chloe, de Sousa, Christiani B, Tiezzi, Daniel G, Wachter, David L, Herpel, Esther, Taran, Florin Andrei, Modugno, Francesmary, Nelson, Gregg, Lubiński, Jan, Menkiszak, Janusz, Alsop, Jennifer, Lester, Jenny, García-Donas, Jesús, Nation, Jill, Hung, Jillian, Palacios, José, Rothstein, Joseph H, Kelley, Joseph L, de Andrade, Jurandyr M, Robles-Díaz, Luis, Intermaggio, Maria P, Widschwendter, Martin, Beckmann, Matthias W, Ruebner, Matthias, Jimenez-Linan, Mercedes, Singh, Naveena, Oszurek, Oleg, Harnett, Paul R, Rambau, Peter F, Sinn, Peter, Wagner, Philipp, Ghatage, Prafull, Sharma, Raghwa, Edwards, Robert P, Ness, Roberta B, Orsulic, Sandra, Brucker, Sara Y, Johnatty, Sharon E, Longacre, Teri A, Ursula, Eilber, McGuire, Valerie, Sieh, Weiva, Natanzon, Yanina, Li, Zheng, Whittemore, Alice S, Anna, deFazio, Staebler, Annette, Karlan, Beth Y, Gilks, Blake, Bowtell, David D, Høgdall, Estrid, Candido dos Reis, Francisco J, Steed, Helen, Campbell, Ian G, Gronwald, Jacek, Benítez, Javier, Koziak, Jennifer M, Chang-Claude, Jenny, Moysich, Kirsten B, Kelemen, Linda E, Cook, Linda S, Goodman, Marc T, García, María José, Fasching, Peter A, Kommoss, Stefan, Deen, Suha, Kjaer, Susanne K, Menon, Usha, Brenton, James D, Pharoah, Paul DP, Chenevix-Trench, Georgia, Huntsman, David G, Winham, Stacey J, Köbel, Martin, Ramus, Susan J

“…Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic…”
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Immunological configuration of ovarian carcinoma: features and impact on disease outcome by Fucikova, Jitka, Coosemans, An, Orsulic, Sandra, Cibula, David, Vergote, Ignace, Galluzzi, Lorenzo, Spisek, Radek

“…Epithelial ovarian carcinoma (EOC) is a relatively rare malignancy but is the fifth-leading cause of cancer-related death in women, largely reflecting early,…”
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Hippo Pathway Effector Yap Is an Ovarian Cancer Oncogene by HALL, Chad A, RUNSHENG WANG, JIANGYONG MIAO, OLIVA, Esther, XIAOYUN SHEN, WHEELER, Thomas, HILSENBECK, Susan G, ORSULIC, Sandra, GOODE, Scott

“…The Hippo pathway regulates organ size and tumorigenesis in Drosophila and mammals and is altered in a variety of human cancers, yet it remains unclear if the…”
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A Paradoxical Correlation of Cancer-Associated Fibroblasts With Survival Outcomes in B-Cell Lymphomas and Carcinomas by Haro, Marcela, Orsulic, Sandra

“…The tumor microenvironment is increasingly recognized as an active participant in tumor progression. A recent pan-cancer genomic profile analysis has revealed…”
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Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers by Deng, Shan, Yang, Xiaojun, Lassus, Heini, Liang, Shun, Kaur, Sippy, Ye, Qunrui, Li, Chunsheng, Wang, Li-Ping, Roby, Katherine F, Orsulic, Sandra, Connolly, Denise C, Zhang, Youcheng, Montone, Kathleen, Bützow, Ralf, Coukos, George, Zhang, Lin

“…Aldehyde dehydrogenase isoform 1 (ALDH1) has been proved useful for the identification of cancer stem cells. However, our knowledge of the expression and…”
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Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas by Broz, Marina T., Ko, Emily Y., Ishaya, Kristin, Xiao, Jinfen, De Simone, Marco, Hoi, Xen Ping, Piras, Roberta, Gala, Basia, Tessaro, Fernando H. G., Karlstaedt, Anja, Orsulic, Sandra, Lund, Amanda W., Chan, Keith Syson, Guarnerio, Jlenia

“…T cell-based immunotherapies have exhibited promising outcomes in tumor control; however, their efficacy is limited in immune-excluded tumors…”
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Editorial: The Tumor Microenvironment: Recent Advances and Novel Therapeutic Approaches by Korkaya, Hasan, Orsulic, Sandra

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Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer by Kasikova, Lenka, Rakova, Jana, Hensler, Michal, Lanickova, Tereza, Tomankova, Jana, Pasulka, Josef, Drozenova, Jana, Mojzisova, Katerina, Fialova, Anna, Vosahlikova, Sarka, Laco, Jan, Ryska, Ales, Dundr, Pavel, Kocian, Roman, Brtnicky, Tomas, Skapa, Petr, Capkova, Linda, Kovar, Marek, Prochazka, Jan, Praznovec, Ivan, Koblizek, Vladimir, Taskova, Alice, Tanaka, Hisashi, Lischke, Robert, Mendez, Fernando Casas, Vachtenheim, Jiri, Heinzelmann-Schwarz, Viola, Jacob, Francis, McNeish, Iain A., Halaska, Michal J., Rob, Lukas, Cibula, David, Orsulic, Sandra, Galluzzi, Lorenzo, Spisek, Radek, Fucikova, Jitka

“…Intratumoral tertiary lymphoid structures (TLSs) have been associated with improved outcome in various cohorts of patients with cancer, reflecting their…”
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Computational pathology in ovarian cancer by Orsulic, Sandra, John, Joshi, Walts, Ann E., Gertych, Arkadiusz

“…Histopathologic evaluations of tissue sections are key to diagnosing and managing ovarian cancer. Pathologists empirically assess and integrate visual…”
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Identification of Infertility-Associated Topologically Important Genes Using Weighted Co-expression Network Analysis by Wu, Jingni, Xia, Xiaomeng, Hu, Ye, Fang, Xiaoling, Orsulic, Sandra

“…Endometriosis has been associated with a high risk of infertility. However, the underlying molecular mechanism of infertility in endometriosis remains poorly…”
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Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells by Goldberg, Michael S., Xing, Deyin, Ren, Yin, Orsulic, Sandra, Bhatia, Sangeeta N., Sharp, Phillip A.

“…Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP1) with small molecules has been shown to be an effective treatment for ovarian cancer…”
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Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors by Lahiguera, Álvaro, Hyroššová, Petra, Figueras, Agnès, Garzón, Diana, Moreno, Roger, Soto‐Cerrato, Vanessa, McNeish, Iain, Serra, Violeta, Lazaro, Conxi, Barretina, Pilar, Brunet, Joan, Menéndez, Javier, Matias‐Guiu, Xavier, Vidal, August, Villanueva, Alberto, Taylor‐Harding, Barbie, Tanaka, Hisashi, Orsulic, Sandra, Junza, Alexandra, Yanes, Oscar, Muñoz‐Pinedo, Cristina, Palomero, Luís, Pujana, Miquel Àngel, Perales, José Carlos, Viñals, Francesc

“…Mitochondrial metabolism and the generation of reactive oxygen species (ROS) contribute to the acquisition of DNA mutations and genomic instability in cancer…”
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Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS by Taylor-Harding, Barbie, Aspuria, Paul-Joseph, Agadjanian, Hasmik, Cheon, Dong-Joo, Mizuno, Takako, Greenberg, Danielle, Allen, Jenieke R, Spurka, Lindsay, Funari, Vincent, Spiteri, Elizabeth, Wang, Qiang, Orsulic, Sandra, Walsh, Christine, Karlan, Beth Y, Wiedemeyer, W Ruprecht

“…High-grade serous ovarian cancers (HGSOC) are genomically complex, heterogeneous cancers with a high mortality rate, due to acquired chemoresistance and lack…”
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