Search Results - "Orson, Frank M"

A vaccine against methamphetamine attenuates its behavioral effects in mice by Shen, Xiaoyun Y, Kosten, Therese A, Lopez, Angel Y, Kinsey, Berma M, Kosten, Thomas R, Orson, Frank M

“…Abstract Background Vaccines have treatment potential for methamphetamine (MA) addiction. We tested whether a conjugate vaccine against MA…”
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Active and Passive Immunization with an Anti-Methamphetamine Vaccine Attenuates the Behavioral and Cardiovascular Effects of Methamphetamine by Haile, Colin N, Varner, Kurt J, Huijing, Xia, Arora, Reetakshi, Orson, Frank M, Kosten, Thomas R, Kosten, Therese A

“…Background: Methamphetamine use disorder (MUD) is a growing health concern with no FDA-approved treatment. The present series of studies build upon our…”
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Probing cocaine-antibody interactions in buffer and human serum by Ramakrishnan, Muthu, Alves De Melo, Fernando, Kinsey, Berma M, Ladbury, John E, Kosten, Thomas R, Orson, Frank M

“…Despite progress in cocaine immunotherapy, the kinetic and thermodynamic properties of antibodies which bind to cocaine and its metabolites are not well…”
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Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion by Carroll, Marilyn E, Zlebnik, Natalie E, Anker, Justin J, Kosten, Thomas R, Orson, Frank M, Shen, Xiaoyun, Kinsey, Berma, Parks, Robin J, Gao, Yang, Brimijoin, Stephen

“…Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH)…”
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Fibrin Complexes From The Sputum Of Human Asthmatics Contain Viable Fungi by Maskatia, Rani, Dr, Landers, Cameron, BS, Li, Evan, Dr, Rossen, Roger, Dr, Orson, Frank M., Dr, Corry, David B., Dr

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Hepatocyte Growth Factor Gene Transfer to Alveolar Septa for Effective Suppression of Lung Fibrosis by Watanabe, Masaki, Ebina, Masahito, Orson, Frank M, Nakamura, Akira, Kubota, Kazuo, Koinuma, Daizo, Akiyama, Ken-ichi, Maemondo, Makoto, Okouchi, Shinya, Tahara, Minoru, Matsumoto, Kunio, Nakamura, Toshikazu, Nukiwa, Toshihiro

“…We examined therapeutic gene transfer of human hepatocyte growth factor (hHGF) to alveolar septa in mouse bleomycin-induced lung fibrosis using macroaggregated…”
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Isolation and characterization of two complete Ara h 2 isoforms cDNA by Chatel, Jean-Marc, Bernard, Hervé, Orson, Frank M

“…Ara h 2 is a major peanut allergen recognized by IgE in more than 90% of patients. After electrophoretic separation the purified protein exists as a doublet,…”
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Vaccines for cocaine abuse by Orson, Frank M., Kinsey, Berma M., Singh, Rana A.K., Wu, Yan, Kosten, Thomas R.

“…Treatments for cocaine abuse have been disappointingly ineffective, especially in comparison with those for some other abused substances. A new approach, using…”
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Preclinical efficacy of an anti‐methamphetamine vaccine using E6020 adjuvant by Arora, Reetakshi, Haile, Colin N., Kosten, Therese A., Wu, Yan, Ramakrishnan, Muthu, Hawkins, Lynn D., Orson, Frank M., Kosten, Thomas R.

“…Background and Objective Methamphetamine (MA) substance use disorder (SUD) does not have an efficacious pharmacotherapy. We developed a MA vaccine and…”
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The concept of pharmacologic cocaine interception as a treatment for drug abuse by Gao, Yang, Orson, Frank M., Kinsey, Berma, Kosten, Tom, Brimijoin, Stephen

“…Cocaine access to brain tissue and associated cocaine-induced behaviors are substantially reduced in rats and mice by significant plasma levels of an enzyme…”
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Substance Abuse Vaccines by Orson, Frank M., Kinsey, Berma M., Singh, Rana A.K., Wu, Yan, Gardner, Tracie, Kosten, Thomas R.

“…Conventional substance‐abuse treatments have only had limited success for drugs such as cocaine, nicotine, methamphetamine, and phencyclidine. New approaches,…”
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A morphine conjugate vaccine attenuates the behavioral effects of morphine in rats by Kosten, Therese A., Shen, Xiaoyun Y., O'Malley, Patrick W., Kinsey, Berma M., Lykissa, Ernest D., Orson, Frank M., Kosten, Thomas R.

“…Vaccines for opioid dependence may provide a treatment that would reduce or slow the distribution of the drug to brain, thus reducing the drug's reinforcing…”
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Anti-drug vaccines to treat substance abuse by Kinsey, Berma M, Jackson, David C, Orson, Frank M

“…Substance abuse is a growing world‐wide problem. The big four drugs of abuse that might lend themselves to immunotherapy are nicotine, cocaine, morphine/heroin…”
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Altered methamphetamine place conditioning in mice vaccinated with a succinyl-methamphetamine-tetanus-toxoid vaccine by Haile, Colin N., Kosten, Therese A., Shen, Xiaoyun Y., O'Malley, Patrick W., Winoske, Kevin J., Kinsey, Berma M., Wu, Yan, Huang, Zhen, Lykissa, Ernest D., Naidu, Naga, Cox, Joseph A., Arora, Reetakshi, Kosten, Thomas R., Orson, Frank M.

“…Background and Objectives We previously reported that an anti‐methamphetamine (MA) vaccine attenuated drug‐conditioned effects in mice, but it used a carrier…”
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Hapten Optimization for Cocaine Vaccine with Improved Cocaine Recognition by Ramakrishnan, Muthu, Kinsey, Berma M., Singh, Rana A., Kosten, Thomas R., Orson, Frank M.

“…In the absence of any effective pharmacotherapy for cocaine addiction, immunotherapy is being actively pursued as a therapeutic intervention. While several…”
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Anti-cocaine vaccine development by Kinsey, Berma M, Kosten, Thomas R, Orson, Frank M

“…Cocaine abuse is an ongoing and serious problem that has led to the growth of a brutal criminal enterprise, particularly in the Americas and Europe. At…”
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Spontaneous Development of IgM Anti-Cocaine Antibodies in Habitual Cocaine Users: Effect on IgG Antibody Responses to a Cocaine Cholera Toxin B Conjugate Vaccine by Orson, Frank M., Rossen, Roger D., Shen, Xiaoyun, Lopez, Angel Y., Wu, Yan, Kosten, Thomas R.

“…Background and Objectives In cocaine vaccine studies, only a minority of subjects made strong antibody responses. To investigate this issue, IgG and IgM…”
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The future potential for cocaine vaccines by Orson, Frank M, Wang, Rongfu, Brimijoin, Stephen, Kinsey, Berma M, Singh, Rana Ak, Ramakrishnan, Muthu, Wang, Helen Y, Kosten, Thomas R

“…Addiction to cocaine is a major problem around the world, but especially in developed countries where the combination of wealth and user demand has created…”
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Dose-dependent changes in the locomotor responses to methamphetamine in BALB/c mice: Low doses induce hypolocomotion by Singh, Rana A.K., Kosten, Therese A., Kinsey, Berma M., Shen, Xiaoyun, Lopez, Angel Y., Kosten, Thomas R., Orson, Frank M.

“…The overall goal of the present study was to determine the effects of different doses of (+)-methamphetamine (meth) on locomotor activity of Balb/C mice. Four…”
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Attenuation of cocaine-induced locomotor activity in male and female mice by active immunization by Kosten, Therese A., Shen, Xiaoyun Y., Kinsey, Berma M., Kosten, Thomas R., Orson, Frank M.

“…Background and Objectives Immunotherapy for drug addiction is being investigated in several laboratories but most studies are conducted in animals of one sex…”
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