Search Results - "Orsolić, Ines"

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress by Bursać, Sladana, Brdovčak, Maja Cokarić, Pfannkuchen, Martin, Orsolić, Ines, Golomb, Lior, Zhu, Yan, Katz, Chen, Daftuar, Lilyn, Grabušić, Kristina, Vukelić, Iva, Filić, Vedrana, Oren, Moshe, Prives, Carol, Volarević, Siniša

“…Impairment of ribosomal biogenesis can activate the p53 protein independently of DNA damage. The ability of ribosomal proteins L5, L11, L23, L26, or S7 to bind…”
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Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint by Oršolić, Ines, Bursać, Slađana, Jurada, Deana, Drmić Hofman, Irena, Dembić, Zlatko, Bartek, Jiri, Mihalek, Ivana, Volarević, Siniša

“…Perturbations in ribosome biogenesis have been associated with cancer. Such aberrations activate p53 through the RPL5/RPL11/5S rRNA complex-mediated inhibition…”
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Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis by Lindström, Mikael S., Jurada, Deana, Bursac, Sladana, Orsolic, Ines, Bartek, Jiri, Volarevic, Sinisa

“…The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that are responsible for protein synthesis. A wealth of research over…”
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The relationship between the nucleolus and cancer: Current evidence and emerging paradigms by Orsolic, Ines, Jurada, Deana, Pullen, Nick, Oren, Moshe, Eliopoulos, Aristides G, Volarevic, Sinisa

“…Abstract The nucleolus is the most prominent nuclear substructure assigned to produce ribosomes; molecular machines that are responsible for carrying out…”
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Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival by Bublik, Débora R., Bursać, Slađana, Sheffer, Michal, Oršolíc, Ines, Shalit, Tali, Tarcic, Ohad, Kotler, Eran, Mouhadeb, Odelia, Hoffman, Yonit, Fuchs, Gilad, Levin, Yishai, Volarević, Siniša, Oren, Moshe

“…The microRNA miR-504 targets TP53 mRNA encoding the p53 tumor suppressor. miR-504 resides within the fibroblast growth factor 13 (FGF13) gene, which is…”
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Genetic and epigenetic defects of the RNA modification machinery in cancer by Orsolic, Ines, Carrier, Arnaud, Esteller, Manel

“…Cancer was initially considered to be an exclusively genetic disease, but an interplay of dysregulated genetic and epigenetic mechanisms is now known to…”
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Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer by Velimezi, Georgia, Liontos, Michalis, Vougas, Konstantinos, Roumeliotis, Theodoros, Bartkova, Jirina, Sideridou, Maria, Dereli-Oz, Ayguel, Kocylowski, Maciej, Pateras, Ioannis S., Evangelou, Kostas, Kotsinas, Athanassios, Orsolic, Ines, Bursac, Sladana, Cokaric-Brdovcak, Maja, Zoumpourlis, Vassilis, Kletsas, Dimitris, Papafotiou, George, Klinakis, Apostolos, Volarevic, Sinisa, Gu, Wei, Bartek, Jiri, Halazonetis, Thanos D., Gorgoulis, Vassilis G.

“…The DNA damage response (DDR) pathway and ARF function as barriers to cancer development. Although commonly regarded as operating independently of each other,…”
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Erratum: Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer by Velimezi, Georgia, Liontos, Michalis, Vougas, Konstantinos, Roumeliotis, Theodoros, Bartkova, Jirina, Sideridou, Maria, Dereli-Oz, Ayguel, Kocylowski, Maciej, Pateras, Ioannis S., Evangelou, Kostas, Kotsinas, Athanassios, Orsolic, Ines, Bursac, Sladana, Cokaric-Brdovcak, Maja, Zoumpourlis, Vassilis, Kletsas, Dimitris, Papafotiou, George, Klinakis, Apostolos, Volarevic, Sinisa, Gu, Wei, Bartek, Jiri, Halazonetis, Thanos D., Gorgoulis, Vassilis G.

“…Nat. Cell Biol. 15, 967–977 (2013); published online 14 July 2013; corrected after print 28 August 2013 In the version of this Article originally published,…”
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Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer by Velimezi, Georgia, Liontos, Michalis, Vougas, Konstantinos, Roumeliotis, Theodoros, Bartkova, Jirina, Sideridou, Maria, Dereli-oz, Ayguel, Kocylowski, Maciej, Pateras, Ioannis S, Evangelou, Kostas, Kotsinas, Athanassios, Orsolic, Ines, Bursac, Sladana, Cokaric-brdovcak, Maja, Zoumpourlis, Vassilis, Kletsas, Dimitris, Papafotiou, George, Klinakis, Apostolos, Volarevic, Sinisa, Gu, Wei, Bartek, Jiri, Halazonetis, Thanos D, Gorgoulis, Vassilis G

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