Search Results - "Orsiere, T."

In vivo exposure to benzo(a)pyrene induces significant DNA damage in mouse oocytes and cumulus cells by Einaudi, L., Courbiere, B., Tassistro, V., Prevot, C., Sari-Minodier, I., Orsiere, T., Perrin, J.

“…STUDY QUESTION Does in vivo exposure to benzo(a)pyrene (BaP) induce DNA damage in oocytes and cumulus cells (CCs) in mice? SUMMARY ANSWER Significant increases…”
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Lead and zinc concentrations in household dust and toenails of the residents (Estarreja, Portugal): a source-pathway-fate model by Marinho Reis, A Paula, Cave, M, Sousa, A J, Wragg, J, Rangel, M J, Oliveira, A R, Patinha, C, Rocha, F, Orsiere, T, Noack, Y

“…This paper describes a methodology developed to assess and apportion probable indoor and outdoor sources of potentially toxic elements while identifying…”
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Design of model tokamak particles for future toxicity studies: Morphology and physical characterization by Bernard, E., Jambon, F., Georges, I., Sanles Sobrido, M., Rose, J., Herlin-Boime, N., Miserque, F., Beaunier, P., Vrel, D., Dine, S., Hodille, E., Chêne, J., Garcia-Argote, S., Pieters, G., Peillon, S., Gensdarmes, F., Dinescu, G., Acsente, T., Uboldi, C., Orsiere, T., Malard, V., Rousseau, B., Delaporte, Ph, Grisolia, C.

“…During ITER operation, it is expected that the large panel of plasma-wall interactions triggers the production of dust particles from the tungsten and…”
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Genetic polymorphisms and micronucleus formation: A review of the literature by Iarmarcovai, G., Bonassi, S., Botta, A., Baan, R.A., Orsière, T.

“…The formation of micronuclei (MN) is extensively used in molecular epidemiology as a biomarker of chromosomal damage, genome instability, and eventually of…”
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Micronuclei frequency in peripheral blood lymphocytes of cancer patients: A meta-analysis by Iarmarcovai, G., Ceppi, M., Botta, A., Orsière, T., Bonassi, S.

“…Micronuclei (MN) frequency is a biomarker of chromosomal damage, genome instability, and cancer risk that integrates acquired mutations and genetic…”
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Genotoxic risk assessment of pathology and anatomy laboratory workers exposed to formaldehyde by use of personal air sampling and analysis of DNA damage in peripheral lymphocytes by Orsière, T., Sari-Minodier, I., Iarmarcovai, G., Botta, A.

“…A study was conducted to evaluate the genotoxic effect of occupational exposure to formaldehyde on pathology and anatomy laboratory workers. The level of…”
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Cytogenetic monitoring by use of the micronucleus assay among hospital workers exposed to low doses of ionizing radiation by Sari-Minodier, I., Orsière, T., Auquier, P., Martin, F., Botta, A.

“…The aim of this study was to assess occupationally induced chromosomal damage in a large population of hospital workers exposed to low doses of ionizing…”
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Comet assay on thawed embryos: An optimized technique to evaluate DNA damage in mouse embryos by Rolland, L., Courbiere, B., Tassistro, V., Sansoni, A., Orsière, T., Liu, W., Di Giorgio, C., Perrin, J.

“…Our objective was to optimize the CA technique on mammal embryos. 1000 frozen 2-cell embryos from B6CBA mice were used. Based on a literature review, and after…”
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Number of centromeric signals in micronuclei and mechanisms of aneuploidy by Iarmarcovai, G., Botta, A., Orsière, T.

“…Genome instability or changes in chromosome structure and number are important facets of oncogenesis. Aneuploidy is a major cause of human reproductive failure…”
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A new approach for the oocyte genotoxicity assay: adaptation of comet assay on mouse cumulus–oocyte complexes by Greco, F, Perrin, J, Auffan, M, Tassistro, V, Orsière, T, Courbiere, B

“…Conventional genotoxicity tests are technically difficult to apply to oocytes, and results obtained on somatic cells cannot be extrapolated to gametes. We have…”
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Assessment of respiratory toxicity of ITER-like tungsten metal nanoparticles using an in vitro 3D human airway epithelium model by George, I., Hagège, A., Herlin, N., Vrel, D., Rose, J., Sanles, M., Orsière, T., Uboldi, C., Grisolia, C., Rousseau, B., Malard, V.

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Exposure to genotoxic agents, host factors, and lifestyle influence the number of centromeric signals in micronuclei: a pooled re-analysis by Iarmarcovai, G, Bonassi, S, Sari-Minodier, I, Baciuchka-Palmaro, M, Botta, A, Orsière, T

“…We pooled data from three biomonitoring studies using the cytokinesis-block micronucleus assay in peripheral blood lymphocytes in combination with fluorescence…”
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Risk assessment of welders using analysis of eight metals by ICP-MS in blood and urine and DNA damage evaluation by the comet and micronucleus assays; influence of XRCC1 and XRCC3 polymorphisms by Iarmarcovai, G., Sari-Minodier, I., Chaspoul, F., Botta, C., De Méo, M., Orsière, T., Bergé-Lefranc, J.L., Gallice, P., Botta, A.

“…The aims of the present study were to assess the occupational risk of welders using analysis of metals in biological fluids, DNA damage evaluation by…”
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Oxidative stress and DNA damages induced by 1-nitropyrene in human lung fibroblasts: New insights into the mechanisms of genotoxicity and EPR-spin trapping direct monitoring of free radicals at subcellular levels by Cassien, M., Tassistro, V., Culcasi, M., Ricquebourg, E., Thétiot-Laurent, S., Mercier, A., Orsière, T., Pietri, S.

“…Polycyclic aromatic hydrocarbons (PAHs) and nitro-PAHs are ubiquitous contaminants released in the atmosphere from the incomplete combustion of organic matter…”
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The expression of genes induced in melanocytes by exposure to 365-nm UVA: study by cDNA arrays and real-time quantitative RT-PCR by Jean, Séverine, Bideau, Chantal, Bellon, Laurence, Halimi, Gilles, De Méo, Michel, Orsière, Thierry, Dumenil, Gérard, Bergé-Lefranc, Jean-Louis, Botta, Alain

“…Ultraviolet A radiation (UVA; 320–400 nm) constitutes more than 90% of the terrestrial UV solar energy. This type of radiation generates reactive oxygen…”
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A combined analysis of XRCC1, XRCC3, GSTM1 and GSTT1 polymorphisms and centromere content of micronuclei in welders by Iarmarcovai, G., Sari-Minodier, I., Orsière, T., De Méo, M., Gallice, P., Bideau, C., Iniesta, D., Pompili, J., Bergé-Lefranc, J.L., Botta, A.

“…The aims of the present study were to assess clastogenic and aneugenic properties of welding fumes using fluorescent in situ hybridization (FISH) with a human…”
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Cytogenetic monitoring of industrial radiographers using the micronucleus assay by Sari-Minodier, I., Orsière, T., Bellon, L., Pompili, J., Sapin, C., Botta, A.

“…Industrial radiography is the process of using either gamma-emitting radionuclide sources or X-ray machines to examine the safety of industrial materials…”
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Genotoxicity screening using BlueScreen HC™ and BlueScreen HC S9™ assays: A validation study by Orsière, T., Pearson, N., Valin, M., Sire, G., Sarlang, S., Forster, R., Legrand, J.

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Comparison of the relative sensitivity of human lymphocytes and mouse splenocytes to two spindle poisons by Steiblen, G., Orsière, T., Pallen, C., Botta, A., Marzin, D.

“…Aneugenic compounds act on non-DNA targets to exert genotoxicity via an indirect mechanism. In contrast to DNA-binding agents, these compounds are expected to…”
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Genotoxic and clastogenic effects of doxorubicin by Villani, P, Orsière, T, Duffaud, F, Digue, L, Bouvenot, G, Botta, A

“…Doxorubicine is an anthracyclin used widely in medical oncology. The purpose of this investigation was to evaluate the genotoxic and clastogenic effects of…”
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