Search Results - "Orser, B. A."

Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar by Jevtovic-Todorovic, V, Absalom, A.R., Blomgren, K, Brambrink, A, Crosby, G, Culley, D.J., Fiskum, G, Giffard, R.G., Herold, K.F., Loepke, A.W., Ma, D, Orser, B.A., Planel, E, Slikker, W, Soriano, S.G., Stratmann, G, Vutskits, L, Xie, Z, Hemmings, H.C.

“…Although previously considered entirely reversible, general anaesthesia is now being viewed as a potentially significant risk to cognitive performance at both…”
Get full text

G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors by MacDonald, J. F, Lu, W-Y, Xiong, Z-G, Lei, S, Orser, B. A, Dudek, E, Browning, M. D

“…The N-methyl-D-aspartate (NMDA) receptor contributes to synaptic plasticity in the central nervous system and is both serine-threonine and tyrosine…”
Get full text

Inhibition by propofol (2,6 di‐isopropylphenol) of the N‐methyl‐D‐aspartate subtype of glutamate receptor in cultured hippocampal neurones by Orser, Beverley A., Bertlik, Maria, Wang, Lu‐Yang, MacDonald, John F.

“…1 The effects of propofol (2,6 di‐isopropylphenol) on responses to the selective glutamate receptor agonists, N‐methyl‐D‐aspartate (NMDA) and kainate, were…”
Get full text

Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors by ORSER, B. A, PENNEFATHER, P. S, MACDONALD, J. F

“…The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor is blocked by ketamine, and this action likely contributes to ketamine's anesthetic and analgesic…”
Get full text

Medication errors in anesthetic practice: a survey of 687 practitioners by ORSER, Beverley A, CHEN, Robert J. B, YEE, Doreen A

“…The objectives of this study were to determine: 1) if anesthesiologists had experienced a medication error and 2) to identify causal factors. The perceived…”
Get full text

Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons by Orser, BA, Wang, LY, Pennefather, PS, MacDonald, JF

“…Propofol (2,6 di-isopropylphenol) is an alkyphenol recently introduced for use as a general anesthetic. The modulation of GABAA receptor activation and…”
Get full text

Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A by Wang, Lu-Yang, Orser, Bev A, Brautigan, David L, MacDonald, John F

“…Phosphorylation of glutamate receptors is probably an important mechanism for modulating excitatory transmission. However, there is little direct evidence to…”
Get full text

Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src by Macdonald, D S, Weerapura, M, Beazely, M A, Martin, L, Czerwinski, W, Roder, J C, Orser, B A, MacDonald, J F

“…At CA1 synapses, activation of NMDA receptors (NMDARs) is required for the induction of both long-term potentiation and depression. The basal level of activity…”
Get full text

External compression of a nasotracheal tube due to the displaced bony fragments of multiple LeFort fractures by JOO, D. T, ORSER, B. A

Get full text

Potentiation of GABAA receptor activity by volatile anaesthetics is reduced by α5GABAA receptor-preferring inverse agonists by Lecker, I., Yin, Y., Wang, D.S., Orser, B.A.

“…Animal studies have shown that memory deficits in the early post-anaesthetic period can be prevented by pre-treatment with an inverse agonist that…”
Get full text

Blockade of glutamate receptors and barbiturate anesthesia : Increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice by JOO, D. T, ZHIGANG XIONG, MACDONALD, J. F, ZHENGPING JIA, RODER, J, SONNER, J, ORSER, B. A

“…Barbiturates enhance gamma-aminobutyric acid type A (GABA(A)) receptor function and also inhibit the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid…”
Get full text

In CA1 Pyramidal Neurons of the Hippocampus Protein Kinase C Regulates Calcium-Dependent Inactivation of NMDA Receptors by Lu, Wei-Yang, Jackson, Michael F, Bai, Donglin, Orser, Beverley A, MacDonald, John F

“…The NMDA subtype of the glutamate-gated channel exhibits a high permeability to Ca(2+). The influx of Ca(2+) through NMDA channels is limited by a rapid and…”
Get full text

General anaesthetics and their effects on GABA A receptor desensitization by Orser, B.A., McAdam, L.C., Roder, S., MacDonald, J.F.

“…1. Intravenous anaesthetics, including propofol and thiopental have at least three distinct effects on GABA A receptor function. 2. Low concentrations of these…”
Get full text

Drug safety in Canada: 2 steps forward, 1 step back by Orser, Beverley A, Dionee, Claire, Hyland, Sylvia

Get full text

Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons by Bai, D, Zhu, G, Pennefather, P, Jackson, M F, MacDonald, J F, Orser, B A

“…gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter, activates a persistent low amplitude tonic current in several brain regions in…”
Get more information

The Effects of Midazolam on Propofol-Induced Anesthesia: Propofol Dose Requirements, Mood Profiles, and Perioperative Dreams by Oxorn, Donald C, Ferris, Lorraine E, Harrington, Ellen, Orser, Beverley A

“…This study examined the effects of midazolam on the doses of propofol required for the induction of hypnosis and the maintenance of propofol/nitrous oxide…”
Get full text

Cation selective channel in fetal alveolar type II epithelium by Orser, B A, Bertlik, M, Fedorko, L, O'Brodovich, H

“…A cation selective channel was identified in the apical membrane of fetal rat (Wistar) alveolar type II epithelium using the patch clamp technique. The single…”
Get more information

Modulation of AMPA receptors by a novel organic nitrate by Toong, S, Xiong, Z G, Zavorin, S I, Bai, D, Orser, B A, Thatcher, G R, Reynolds, J N, MacDonald, J F

“…Positive modulators of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) channels reduce desensitization and alter their gating kinetics. We have…”
Get more information

The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors by Bai, D, Pennefather, P S, MacDonald, J F, Orser, B A

“…Propofol (2,6-di-isopropylphenol) has multiple actions on GABA(A) receptor function that act in concert to potentiate GABA-evoked currents. To understand how…”
Get full text

An anaesthetic drug error : minimizing the risk by ORSER, B. A, OXORN, D. C

“…A medication error caused a near fatal cardiac arrest in a previously healthy patient undergoing elective surgery. Inadvertent epinephrine injection induced…”
Get full text