Search Results - "Orschell, Christie M"

Peripheral blood endothelial progenitor cells are derived from monocyte/macrophages and secrete angiogenic growth factors by REHMAN, Jalees, JINGLING LI, ORSCHELL, Christie M, MARCH, Keith L

“…Endothelial progenitor cells (EPCs) have been isolated from peripheral blood and can enhance angiogenesis after infusion into host animals. It is not known…”
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Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes by Gasperetti, Tracy, Miller, Tessa, Gao, Feng, Narayanan, Jayashree, Jacobs, Elizabeth R, Szabo, Aniko, Cox, George N, Orschell, Christie M, Fish, Brian L, Medhora, Meetha

“…There is a need for countermeasures to mitigate lethal acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE). In WAG/RijCmcr…”
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Establishing a Murine Model of the Hematopoietic Syndrome of the Acute Radiation Syndrome by Plett, P Artur, Sampson, Carol H, Chua, Hui Lin, Joshi, Mandar, Booth, Catherine, Gough, Alec, Johnson, Cynthia S, Katz, Barry P, Farese, Ann M, Parker, Jeffrey, MacVittie, Thomas J, Orschell, Christie M

“…ABSTRACTThe authors have developed a murine model of the Hematopoietic Syndrome of the Acute Radiation Syndrome (H-ARS) for efficacy testing of medical…”
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Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2) by Shakhov, Alexander N, Singh, Vijay K, Bone, Frederick, Cheney, Alec, Kononov, Yevgeniy, Krasnov, Peter, Bratanova-Toshkova, Troitza K, Shakhova, Vera V, Young, Jason, Weil, Michael M, Panoskaltsis-Mortari, Angela, Orschell, Christie M, Baker, Patricia S, Gudkov, Andrei, Feinstein, Elena

“…Bacterial lipoproteins (BLP) induce innate immune responses in mammals by activating heterodimeric receptor complexes containing Toll-like receptor 2 (TLR2)…”
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Corrigendum: Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes by Gasperetti, Tracy, Miller, Tessa, Gao, Feng, Narayanan, Jayashree, Jacobs, Elizabeth R, Szabo, Aniko, Cox, George N, Orschell, Christie M, Fish, Brian L, Medhora, Meetha

“…[This corrects the article DOI: 10.3389/fphar.2021.634477.]…”
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Long-Term Hematopoietic Stem Cell Damage in a Murine Model of the Hematopoietic Syndrome of the Acute Radiation Syndrome by Chua, Hui Lin, Plett, P Artur, Sampson, Carol H, Joshi, Mandar, Tabbey, Rebeka, Katz, Barry P, MacVittie, Thomas J, Orschell, Christie M

“…ABSTRACTResidual bone marrow damage (RBMD) persists for years following exposure to radiation and is believed to be due to decreased self-renewal potential of…”
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The delayed effects of acute radiation exposure (DEARE): characteristics, mechanisms, animal models, and promising medical countermeasures by Wu, Tong, Orschell, Christie M.

“…Terrorist use of nuclear weapons and radiation accidents put the human population at risk for exposure to life-threatening levels of radiation. Victims of…”
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Effects of HIV Protease Inhibitor Ritonavir on Akt-Regulated Cell Proliferation in Breast Cancer by SRIRANGAM, Anjaiah, MITRA, Ranjana, ORSCHELL, Christie M, SROUR, Edward F, BLUM, Janice S, DONNER, David, SLEDGE, George W, NAKSHATRI, Harikrishna, POTTER, David A, MU WANG, GORSKI, J. Christopher, BADVE, Sunil, BALDRIDGE, Leeann, HAMILTON, Justin, KISHIMOTO, Hiromitsu, HAWES, John, LANG LI

“…Purpose: These studies were designed to determine whether ritonavir inhibits breast cancer in vitro and in vivo and, if so, how. Experimental Design: Ritonavir…”
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Impact of modeled microgravity on migration, differentiation, and cell cycle control of primitive human hematopoietic progenitor cells by Plett, P.Artur, Abonour, Rafat, Frankovitz, Stacy M., Orschell, Christie M.

“…Migration, proliferation, and differentiation of bone marrow (BM) hematopoietic stem cells (HSC) are important factors in maintaining hematopoietic…”
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The Access Technology Program of the Indiana Clinical Translational Sciences Institute (CTSI): A model to facilitate access to cutting-edge technologies across a state by Orschell, Christie M, Skaar, Todd C, DeFord, Melanie E, Ybe, Joel, Driscol, Julie, Drury, Christine, Reeves, Lilith, Willis, Monte S, Reiter, Jill L, York, Jenna, Orr, Rob, McClintick, Jeanette N, Sors, Thomas G, Hunt, Joe, Cornetta, Kenneth, Shekhar, Anantha

“…Access to cutting-edge technologies is essential for investigators to advance translational research. The Indiana Clinical and Translational Sciences Institute…”
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Establishing a Murine Model of the Hematopoietic Acute Radiation Syndrome by Plett, P Artur, Pelus, Louis M, Orschell, Christie M

“…The hematopoietic system is one of the most sensitive tissues to ionizing radiation, and radiation doses from 2 to 10 gray can result in death from bleeding…”
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Hematopoietic Stem Cell Identification Postirradiation by Patterson, Andrea M, Orschell, Christie M, Pelus, Louis M

“…Radiation exposure is particularly damaging to cells of the hematopoietic system, inducing pancytopenia and bone marrow failure. The study of these processes,…”
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IEPA, a novel radiation countermeasure, alleviates acute radiation syndrome in rodents by Wesolowski, Radoslaw, Fish, Brian L., Eibl, Michael, Bähr, Stella, Munjal Mehta, Srishti, Czajkowski, Maciej T., Gasperetti, Tracy, Orschell, Christie M., Asang, Corinna, Singh, Nikita, Himburg, Heather A., Pleimes, Dirk

“…Repurposing therapeutic agents with existing clinical data is a common strategy for developing radiation countermeasures. IEPA (imidazolyl ethanamide…”
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Mitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function by Capitano, Maegan L, Mohamad, Safa F, Cooper, Scott, Guo, Bin, Huang, Xinxin, Gunawan, Andrea M, Sampson, Carol, Ropa, James, Srour, Edward F, Orschell, Christie M, Broxmeyer, Hal E

“…Bone marrow (BM) hematopoietic stem cells (HSCs) become dysfunctional during aging (i.e., they are increased in number but have an overall reduction in…”
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Age and Sex Divergence in Hematopoietic Radiosensitivity in Aged Mouse Models of the Hematopoietic Acute Radiation Syndrome by Patterson, Andrea M., Vemula, Sasidhar, Plett, P. Artur, Sampson, Carol H., Chua, Hui Lin, Fisher, Alexa, Wu, Tong, Sellamuthu, Rajendran, Feng, Hailin, Katz, Barry P., DesRosiers, Colleen M., Pelus, Louis M., Cox, George N., MacVittie, Thomas J., Orschell, Christie M.

“…The hematopoietic system is highly sensitive to stress from both aging and radiation exposure, and the hematopoietic acute radiation syndrome (H-ARS) should be…”
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Distribution of marrow repopulating cells between bone marrow and spleen early after transplantation by Plett, P. Artur, Frankovitz, Stacy M., Orschell, Christie M.

“…Whether hematopoietic stem cells (HSCs) home selectively to bone marrow (BM) early after transplantation remains an issue of debate. Better understanding of…”
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Effect of Age at Time of Irradiation, Sex, Genetic Diversity, and Granulopoietic Cytokine Radiomitigation on Lifespan and Lymphoma Development in Murine H-ARS Survivors by Plett, P. Artur, Chua, Hui Lin, Wu, Tong, Sampson, Carol H., Guise, Theresa A., Wright, Laura, Pagnotti, Gabriel M., Feng, Hailin, Chin-Sinex, Helen, Pike, Francis, Cox, George N., MacVittie, Thomas J., Sandusky, George, Orschell, Christie M.

“…Acute, high-dose radiation exposure results in life-threatening acute radiation syndrome (ARS) and debilitating delayed effects of acute radiation exposure…”
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Effect of Sex on Biomarker Response in a Mouse Model of the Hematopoietic Acute Radiation Syndrome by Jones, Jace W, Alloush, Jenna, Sellamuthu, Rajendran, Chua, Hui Lin, MacVittie, Thomas J, Orschell, Christie M, Kane, Maureen A

“…ABSTRACTSex is an important confounding variable in biomarker development that must be incorporated into biomarker discovery and validation. Additionally,…”
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Lifelong Residual bone Marrow Damage in Murine Survivors of the Hematopoietic Acute Radiation Syndrome (H-ARS): A Compilation of Studies Comprising the Indiana University Experience by Chua, Hui Lin, Plett, P Artur, Fisher, Alexa, Sampson, Carol H, Vemula, Sasidhar, Feng, Hailin, Sellamuthu, Rajendran, Wu, Tong, MacVittie, Thomas J, Orschell, Christie M

“…ABSTRACTAccurate analyses of the delayed effects of acute radiation exposure in survivors of the hematopoietic acute radiation syndrome are hampered by low…”
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Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE) by Orschell, Christie M., Wu, Tong, Patterson, Andrea M.

“…Purpose of Review Malicious or accidental radiation exposure increases risk for the hematopoietic acute radiation syndrome (H-ARS) and the delayed effects of…”
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