Search Results - "Orrenius, S."

Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease by FADEEL, B., ORRENIUS, S.

“… Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the maintenance of tissue homeostasis in the adult organism…”
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Role of cardiolipin in cytochrome c release from mitochondria by Ott, M, Zhivotovsky, B, Orrenius, S

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Cell cycle and cell death in disease: past, present and future by Zhivotovsky, B., Orrenius, S.

“…  Zhivotovsky B, Orrenius S (Institute of Environmental Medicine, Division of Toxicology, Karolinska Institute, Stockholm, Sweden) Cell cycle and cell death…”
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Mitochondrial targeting of tBid Bax: a role for the TOM complex? by Ott, M, Norberg, E, Zhivotovsky, B, Orrenius, S

“…The release of pro-apoptotic proteins from the mitochondria is a key event in cell death signaling that is regulated by Bcl-2 family proteins. For example,…”
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DNA damage induces two distinct modes of cell death in ovarian carcinomas by Vakifahmetoglu, H, Olsson, M, Tamm, C, Heidari, N, Orrenius, S, Zhivotovsky, B

“…Activation of p53 by cellular stress may lead to either cell cycle arrest or apoptotic cell death. Restrictions in a cell's ability to halt the cell cycle…”
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An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death by Norberg, E, Gogvadze, V, Ott, M, Horn, M, Uhlén, P, Orrenius, S, Zhivotovsky, B

“…Apoptosis-inducing factor (AIF), a flavoprotein with NADH oxidase activity anchored to the mitochondrial inner membrane, is known to be involved in complex I…”
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Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage by VAKIFAHMETOGLU, H, OLSSON, M, ORRENIUS, S, ZHIVOTOVSKY, B

“…Recent findings have established caspase-2 as an important apical regulator in apoptotic pathways leading from DNA damage to release of mitochondrial…”
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Reactive oxygen species generated in different compartments induce cell death, survival, or senescence (vol 57, pg 176, 2013) by Panieri, E, Gogvadze, V, Norberg, E, Venkatesh, R, Orrenius, S, Zhivotovsky, B

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Corrigendum to “Reactive oxygen species generated in different compartments induce cell death, survival, or senescence”. [Free Radic. Biol. Med. 2013 Apr; 57:176–187.] by Panieri, E., Gogvadze, V., Norberg, E., Venkatesh, R., Orrenius, S., Zhivotovsky, B.

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Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli by Elinder, F, Akanda, N, Tofighi, R, Shimizu, S, Tsujimoto, Y, Orrenius, S, Ceccatelli, S

“…Apoptotic cell death is an essential process in the development of the central nervous system and in the pathogenesis of its degenerative diseases. Efflux of…”
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Molecular Mechanisms of Apoptosis Induced by Cytotoxic Chemicals by Robertson, John D., Orrenius, Sten

“…ABSTRACT The purpose of this review article is to discuss established molecular mechanisms of apoptosis and their relevance to cell death induced by…”
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Serine proteases and calpains fulfill important supporting roles in the apoptotic tragedy of the cellular opera by Vandenabeele, P, Orrenius, S, Zhivotovsky, B

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HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53 by Hallgren, O, Gustafsson, L, Irjala, H, Selivanova, G, Orrenius, S, Svanborg, C

“…HAMLET (Human alpha-lactalbumin Made Lethal to Tumor cells) triggers selective tumor cell death in vitro and limits tumor progression in vivo. Dying cells show…”
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Distinct pathways for stimulation of cytochrome c release by etoposide by Robertson, J D, Gogvadze, V, Zhivotovsky, B, Orrenius, S

“…Induction of apoptosis by DNA-damaging agents, such as etoposide, is known to involve the release of mitochondrial cytochrome c, although the mechanism…”
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Neural stem cells and cell death by Ceccatelli, S., Tamm, C., Sleeper, E., Orrenius, S.

“…Neural stem cells (NSC) undergo apoptotic cell death as an essential component of neural development. Here, we present the results of our studies on the…”
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Hsp27 Inhibits Cytochrome c-Mediated Caspase Activation by Sequestering Both Pro-caspase-3 and Cytochrome c by Concannon, C G, Orrenius, S, Samali, A

“…Mitochondrial cytochrome c release in response to pro-apoptotic signals leads to the formation of a cytochrome c/Apaf-1/procaspase-9 complex (the apoptosome)…”
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The most unkindest cut of all : on the multiple roles of mammalian caspases by FADEEL, B, ORRENIUS, S, ZHIVOTOVSKY, B

“…The caspases, first discovered almost a decade ago, are intracellular cysteine proteases which have been shown to play an essential role in the initiation and…”
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Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death by Vakifahmetoglu-Norberg, H, Norberg, E, Perdomo, A B, Olsson, M, Ciccosanti, F, Orrenius, S, Fimia, G M, Piacentini, M, Zhivotovsky, B

“…The caspase family of proteases cleaves large number of proteins resulting in major morphological and biochemical changes during apoptosis. Yet, only a few of…”
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Injected cytochrome c induces apoptosis by Zhivotovsky, Boris, Orrenius, Sten, Brustugun, Odd T, Døskeland, Stein O

“…Mitochondria, the cell's energy-producing organelles, are thought to play a central role in mediating apoptosis, or programmed cell death. Mitochondrial…”
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Early work on apoptosis, an interview with Sten Orrenius by Orrenius, Sten

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