Search Results - "Orren, A"

Complement factor 5 (C5) p.A252T mutation is prevalent in, but not restricted to, sub‐Saharan Africa: implications for the susceptibility to meningococcal disease by Franco‐Jarava, C., Comas, D., Orren, A., Hernández‐González, M., Colobran, R.

“…Summary Complement C5 deficiency (C5D) is a rare primary immunodeficiency associated with recurrent infections, particularly meningitis, by Neisseria species…”
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Complete deficiency of the sixth complement component (C6Q0), susceptibility to Neisseria meningitidis infections and analysis of the frequencies of C6Q0 gene defects in South Africans by Orren, A., Owen, E. P., Henderson, H. E., van der Merwe, L., Leisegang, F., Stassen, C., Potter, P. C.

“…Summary Complete complement component 6 deficiency (C6Q0) is a co‐dominant genetic disease presenting as increased susceptibility to invasive Neisseria…”
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Characterization of a large genomic deletion in four Irish families with C7 deficiency by Thomas, A.D., Orren, A., Connaughton, J., Feighery, C., Morgan, B.P., Roberts, A.G.

“…► The examination of four complement C7 deficient Irish families. ► The identification of the genomic basis of deficiency. ► A PCR based screening method to…”
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Complement component 5 deficiency (C5D) in South Africa by Orren, A., Owen, T., Potter, P.C., Leisegang, F., Morgan, B.P., Wurzner, R.

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Complement component C5 and C6 mutation screening indicated in meningococcal disease in South Africa by Owen, E P, Leisegang, F, Whitelaw, A, Simpson, J, Baker, S, Würzner, R, Potter, P, Orren, A

“…Invasive meningococcal disease (MD), caused by Neisseria meningitidis infection, is endemic in South Africa, with a seasonal peak in winter and spring. There…”
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Screening for complement deficiency by Orren, A

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Molecular mechanisms of complement component C6 deficiency; a hypervariable exon 6 region responsible for three of six reported defects by Orren, A

“…The complement proteins, C5 through C9, together comprise the terminal complement components; on activation these combine to form the membrane attack complex,…”
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Complement‐mediated lipopolysaccharide release and outer membrane damage in Escherichia coli J5: requirement for C9 by O'Hara, A. M., Moran, A. P., Würzner, R., Orren, A.

“…Summary Lipopolysaccharides (LPS) are major antigenic components of the outer membrane of Gram‐negative bacteria and can stimulate activation of the complement…”
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Vaccination against meningococcus in complement‐deficient individuals by Morgan, B P, Orren, A

“…Inherited deficiency syndromes have been described for each of the component proteins and for many of the regulators of the complement system. Although each of…”
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How do mammals distinguish between pathogens and non-self? by Orren, Ann

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The molecular basis of C6 deficiency in the western Cape, South Africa by HOBART, M. J, FERNIE, B. A, FIJEN, K. A. P. M. J, ORREN, A

“…Deficiency of the sixth component of human complement (C6) has been reported in a number of families from the western Cape, South Africa. Meningococcal disease…”
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Meningococcal septicaemia in a C6-deficient patient and effects of plasma transfusion on lipopolysaccharide release by Lehner, P J, Davies, K A, Walport, M J, Cope, A P, Würzner, R, Orren, A, Morgan, B P, Cohen, J

“…Patients whose blood is deficient in the terminal component of complement have an increased susceptibility to meningococcal infection. However, mortality from…”
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Characterization of strains of Neisseria meningitidis recovered from complement-sufficient and complement-deficient patients in the Western Cape Province, South Africa by Orren, A, Caugant, D A, Fijen, C A, Dankert, J, van Schalkwyk, E J, Poolman, J T, Coetzee, G J

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C7 deficiency in an Irish family: a deletion defect which is predominant in the Irish by O'HARA, A. M, FERNIE, B. A, MORAN, A. P, WILLIAMS, Y. E, CONNAUGHTON, J. J, ORREN, A, HOBART, M. J

“…Human deficiencies of terminal complement components are known to be associated with increased susceptibility to Neisseria meningitidis infection. Polymorphic…”
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How partial C7 deficiency with chronic and recurrent bacterial infections can mimic total C7 deficiency: temporary restoration of host C7 levels following plasma transfusion by WÜRZNER, R., PLATONOV, A. E., BELOBORODOV, V. B., PEREVERZEV, A. I., VERSHININA, I. V., FERNIE, B. A., HOBART, M. J., LACHMANN, P. J., ORREN, A.

“…An apparently completely complement C7‐deficient patient with refractory otitis media and two episodes of meningococcal disease was given therapeutic plasma…”
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Prophylaxis against Neisseria meningitidis Infections and Antibody Responses in Patients with Deficiency of the Sixth Component of Complement by Potter, P. C., Frasch, C. E., van der Sande, W. J. M., Cooper, R. C., Patel, Y., Orren, A.

“…Forty South African patients with homozygous deficiency of the sixth component of complement (C6) have been identified in an area where group B meningococcal…”
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Antibodies to meningococcal class 1 outer membrane proteins in South African complement-deficient and complement-sufficient subjects by Orren, A, Warren, R E, Potter, P C, Jones, A M, Lachmann, P J, Poolman, J T

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A new intronic polymorphism in the C7 gene 36 bp from the common expressed C7 M/N polymorphism by Fernie, B A, Würzner, R, Orren, A, Hobart, M

“…We report a new polymorphism in the complement C7 gene that results from an A-C transversion in intron 12, 27 bp upstream of exon 13 (C712.-27) and 36 bp…”
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Functionally active complement proteins C6 and C7 detected in C6‐ and C7‐deficient individuals by WÜRZNER, R., ORREN, A., POTTER, P., MORGAN, B. P., PONARD, D., SPÄTH, P., BRAI, M., SCHULZE, M., HAPPE, L., GÖTZE, O.

“…SUMMARY Two sensitive sandwich ELISAs based on monoclonal antibodies directed to native C6 and C7 allowed the detection and quantitation of these complement…”
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DNA haplotypes of the complement C6 and C7 genes associated with deficiencies of the seventh component; and a new DNA polymorphism in C7 exon 13 by FERNIE, B. A., ORREN, A., SCHLESINGER, M., WÜRZNER, R., PLATONOV, A. E., COOPER, R. C., WILLIAMS, Y. E., HOBART, M. J.

“…Eight common DNA polymorphisms have been described for the linked C6 and C7 genes. We now describe a ninth polymorphism in C7 exon 13 which is located in a…”
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