Search Results - "Orr, William"

redox stress hypothesis of aging by Sohal, Rajindar S, Orr, William C

“…The main objective of this review is to examine the role of endogenous reactive oxygen/nitrogen species (ROS) in the aging process. Until relatively recently,…”
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Tightening the connection between transposable element mobilization and aging by Orr, William C.

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Sleep disturbances and inflammatory bowel disease by Ali, Tauseef, Orr, William C

“…With an estimated 70 million Americans suffering, sleep disorders have become a global issue, and discovering their causes and consequences are the focus of…”
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Larks and owls and disease manifestation by Orr, William C.

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Sleep, immunity and inflammation in gastrointestinal disorders by Ali, Tauseef, Choe, James, Awab, Ahmed, Wagener, Theodore L, Orr, William C

“…Sleep disorders have become a global issue, and discovering their causes and consequences are the focus of many research endeavors. An estimated 70 million…”
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Assessment of the relationship between quality of sleep and disease activity in inflammatory bowel disease patients by Ali, Tauseef, Madhoun, Mohammad F, Orr, William C, Rubin, David T

“…Poor sleep quality is associated with adverse health consequences. Sleep disturbances can impact the immune function and process of inflammation. The…”
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Circadian regulation of glutathione levels and biosynthesis in Drosophila melanogaster by Beaver, Laura M, Klichko, Vladimir I, Chow, Eileen S, Kotwica-Rolinska, Joanna, Williamson, Marisa, Orr, William C, Radyuk, Svetlana N, Giebultowicz, Jadwiga M

“…Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels…”
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Overexpression of antimicrobial peptides contributes to aging through cytotoxic effects in Drosophila tissues by Badinloo, Marziyeh, Nguyen, Elizabeth, Suh, Winston, Alzahrani, Faisal, Castellanos, Jovelyn, Klichko, Vladimir I., Orr, William C., Radyuk, Svetlana N.

“…The innate immune response tends to become hyperactive and proinflammatory in older organisms. We investigated connections between activity of the…”
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The effect of baclofen on objective and subjective sleep measures in a model of transient insomnia by Raad, Samih, Wilkerson, Meredith, Jones, Kellie R., Orr, William C.

“…Insomnia is a common medical complaint. Current pharmacologic treatments have modest efficacy and numerous side effects. Baclofen is a gamma-aminobutyric acid…”
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Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila by Radyuk, Svetlana N, Michalak, Katarzyna, Klichko, Vladimir I, Benes, Judith, Rebrin, Igor, Sohal, Rajindar S, Orr, William C

“…Peroxiredoxin 5 is a distinct isoform of the peroxiredoxin gene family. The antioxidative and anti-apoptotic functions of peroxiredoxin 5 have been extensively…”
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Risk of acute myocardial infarction in patients with gastroesophageal reflux disease: A nationwide population-based study by Lei, Wei-Yi, Wang, Jen-Hung, Wen, Shu-Hui, Yi, Chih-Hsun, Hung, Jui-Sheng, Liu, Tso-Tsai, Orr, William C, Chen, Chien-Lin

“…Gastroesophageal reflux disease (GERD) is a common disease which can cause troublesome symptoms and affect quality of life. In addition to esophageal…”
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The role of peroxiredoxin 4 in inflammatory response and aging by Klichko, Vladimir I., Orr, William C., Radyuk, Svetlana N.

“…In prior studies, we determined that the moderate overexpression of the Drosophila endoplasmic reticulum (ER)-localized peroxiredoxin (Prx), dPrx4, reduced…”
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EKG Abnormalities in a Youth Athlete Following COVID-19: It’s Not Always Myocarditis by Powell, Adam W., Urbina, Elaine M., Orr, William B., Hansen, Jesse E., Baskar, Shankar

“…COVID-19 associated myocarditis following mild infections is rare while incidental findings may be more common. A young athlete fully recovered from a mild…”
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Recanalization of an atretic intramural left main coronary artery after bypass surgery in a pediatric patient with anomalous aortic origin of the left main coronary artery arising from the right sinus of Valsalva by Orr, William B., Johnson, Mark C., Abarbanell, Aaron M., Sintek, Marc

“…We report a pediatric patient with nonatherosclerotic chronic total occlusion (CTO) of the left main coronary artery (LMCA) leading to complete LMCA atresia…”
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Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster by Ferguson, Melissa, Mockett, Robin J, Shen, Yi, Orr, William C, Sohal, Rajindar S

“…The principal objective of the present study was to identify specific alterations in mitochondrial respiratory functions during the aging process. Respiration…”
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Involvement of redox state in the aging of Drosophila melanogaster by Orr, William C, Radyuk, Svetlana N, Sohal, Rajindar S

“…The main objective of this review was to provide an exposition of investigations, conducted in Drosophila melanogaster, on the role of reactive oxygen species…”
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Incorporation of the CardioMEMS™ System During an Exercise Physiology Test in a Pediatric Congenital Heart Disease Patient Contributing to Medical Decision-Making by Orr, William B., Colombo, Jamie N., Roberts, Bayley, Silva, Jennifer N. Avari, Balzer, David

“…Exercise testing among the pediatric congenital heart disease population continues to transform and expand the way patients are evaluated and managed. We…”
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Association between use of proton pump inhibitors and colorectal cancer: A nationwide population-based study by Lei, Wei-Yi, Wang, Jen-Hung, Yi, Chih-Hsun, Liu, Tso-Tsai, Hung, Jui-Sheng, Wong, Ming-Wun, Bair, Ming-Jong, Vaezi, Michael F., Orr, William C., Chen, Chien-Lin

“…Proton pump inhibitors (PPIs) use is associated with hypergastrinemia and gut microbiota alteration. Concern over the risk that these factors may increase…”
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Echocardiograms and bed placement in patients with multisystem inflammatory syndrome in children by Lodhi, Hafsa, Singer, Emma, McGlynn, Mary Claire, Wang, Jinli, Hoefgen, Erik, Srinivasan, Mythili, Orr, William B

“…Understanding of multisystem inflammatory syndrome in children (MIS-C) continues to evolve with extensive evaluations, including echocardiograms, obtained in…”
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Peroxiredoxins Play an Important Role in the Regulation of Immunity and Aging in Drosophila by Odnokoz, Olena, Earland, Noah, Badinloo, Marziyeh, Klichko, Vladimir, Benes, Judith, Orr, William, Radyuk, Svetlana

“…Aberrant immune responses and chronic inflammation can impose significant health risks and promote premature aging. Pro-inflammatory responses are largely…”
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