Search Results - "Orr, Mark T."

Natural Killer Cell Education and Tolerance by Orr, Mark T., Lanier, Lewis L.

“…Natural killer (NK) cells play a key role in the immune response to certain infections and malignancies by direct cytolysis of infected or transformed cells…”
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CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease by Fang, Min, Orr, Mark T., Spee, Pieter, Egebjerg, Thomas, Lanier, Lewis L., Sigal, Luis J.

“…It is well established that natural killer (NK) cells confer resistance to many viral diseases, but in only a few instances the molecular mechanisms whereby NK…”
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Prophylactic efficacy against Mycobacterium tuberculosis using ID93 and lipid-based adjuvant formulations in the mouse model by Baldwin, Susan L, Reese, Valerie A, Larsen, Sasha E, Beebe, Elyse, Guderian, Jeff, Orr, Mark T, Fox, Christopher B, Reed, Steven G, Coler, Rhea N

“…An estimated 10 million people developed tuberculosis (TB) disease in 2019 which underscores the need for a vaccine that prevents disease and reduces…”
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The TLR4 Agonist Vaccine Adjuvant, GLA-SE, Requires Canonical and Atypical Mechanisms of Action for TH1 Induction by Dubois Cauwelaert, Natasha, Desbien, Anthony L, Hudson, Thomas E, Pine, Samuel O, Reed, Steven G, Coler, Rhea N, Orr, Mark T

“…The Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant formulated in a stable emulsion (GLA-SE) promotes strong TH1 and balanced IgG1/IgG2 responses to…”
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A dual TLR agonist adjuvant enhances the immunogenicity and protective efficacy of the tuberculosis vaccine antigen ID93 by Orr, Mark T, Beebe, Elyse A, Hudson, Thomas E, Moon, James J, Fox, Christopher B, Reed, Steven G, Coler, Rhea N

“…With over eight million cases of tuberculosis each year there is a pressing need for the development of new vaccines against Mycobacterium tuberculosis…”
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Mucosal delivery switches the response to an adjuvanted tuberculosis vaccine from systemic TH1 to tissue-resident TH17 responses without impacting the protective efficacy by Orr, Mark T, Beebe, Elyse A, E. Hudson, Thomas, Argilla, David, Huang, Po-Wei D, Reese, Valerie A, Fox, Christopher B, Reed, Steven G, Coler, Rhea N

“…Abstract Pulmonary tuberculosis (TB) remains one of the leading causes of infectious disease death despite widespread usage of the BCG vaccine. A number of new…”
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Semi-synthetic terpenoids with differential adjuvant properties as sustainable replacements for shark squalene in vaccine emulsions by Fisher, Karl J., Kinsey, Robert, Mohamath, Raodoh, Phan, Tony, Liang, Hong, Orr, Mark T., Lykins, William R., Guderian, Jeffrey A., Bakken, Julie, Argilla, David, Ramer-Denisoff, Gabi, Larson, Elise, Qi, Yizhi, Sivananthan, Sandra, Smolyar, Karina, Carter, Darrick, Paddon, Christopher J., Fox, Christopher B.

“…Synthetic biology has allowed for the industrial production of supply-limited sesquiterpenoids such as the antimalarial drug artemisinin and β-farnesene. One…”
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Optimizing a Multi-Component Intranasal Entamoeba Histolytica Vaccine Formulation Using a Design of Experiments Strategy by Abhyankar, Mayuresh M, Orr, Mark T, Kinsey, Robert, Sivananthan, Sandra, Nafziger, Andrew J, Oakland, David N, Young, Mary K, Farr, Laura, Uddin, Md Jashim, Leslie, Jhansi L, Burgess, Stacey L, Liang, Hong, De Lima, Ines, Larson, Elise, Guderian, Jeffrey A, Lin, Susan, Kahn, Aaron, Ghosh, Prakash, Reed, Sierra, Tomai, Mark A, Pedersen, Karl, Petri, Jr, William A, Fox, Christopher B

“…Amebiasis is a neglected tropical disease caused by a. Although the disease burden varies geographically, amebiasis is estimated to account for some 55,000…”
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Formulated Phospholipids as Non-Canonical TLR4 Agonists by Liang, Hong, Lykins, William R, Seydoux, Emilie, Guderian, Jeffrey A, Phan, Tony, Fox, Christopher B, Orr, Mark T

“…Immunogenic agents known as adjuvants play a critical role in many vaccine formulations. Adjuvants often signal through Toll-like receptor (TLR) pathways,…”
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Key roles of adjuvants in modern vaccines by Reed, Steven G, Orr, Mark T, Fox, Christopher B

“…Adjuvants play an important part in vaccines, as they can enhance and shape antigen-specific immune responses. This Review discusses the benefits of adjuvants…”
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Development and function of CD94-deficient natural killer cells by Orr, Mark T, Wu, Jun, Fang, Min, Sigal, Luis J, Spee, Pieter, Egebjerg, Thomas, Dissen, Erik, Fossum, Sigbjørn, Phillips, Joseph H, Lanier, Lewis L

“…The CD94 transmembrane-anchored glycoprotein forms disulfide-bonded heterodimers with the NKG2A subunit to form an inhibitory receptor or with the NKG2C or…”
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Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection by Orr, Mark T, Sun, Joseph C, Hesslein, David G T, Arase, Hisashi, Phillips, Joseph H, Takai, Toshiyuki, Lanier, Lewis L

“…The activating natural killer (NK) cell receptor Ly49H recognizes the mouse cytomegalovirus (MCMV) m157 glycoprotein expressed on the surface of infected cells…”
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Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC by Barao, Isabel, Alvarez, Maite, Ames, Erik, Orr, Mark T., Stefanski, Heather E., Blazar, Bruce R., Lanier, Lewis L., Anderson, Stephen K., Redelman, Doug, Murphy, William J.

“…Natural killer (NK) cell subsets can be defined by the differential expression of inhibitory receptors for MHC class I molecules. Early after congenic HSCT, we…”
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Stressed stability and protective efficacy of lead lyophilized formulations of ID93+GLA-SE tuberculosis vaccine by Archer, Michelle C., McCollum, Joseph, Press, Christopher, Dutill, Timothy S., Liang, Hong, Fedor, Dawn, Kapilow-Cohen, Liam, Gerhardt, Alana, Phan, Tony, Trappler, Edward H., Orr, Mark T., Kramer, Ryan M., Fox, Christopher B.

“…With the recent exception of coronavirus disease 2019 (COVID-19), tuberculosis (TB) causes more deaths globally than any other infectious disease, and…”
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Enhanced Anti- Mycobacterium tuberculosis Immunity over Time with Combined Drug and Immunotherapy Treatment by Larsen, Sasha E, Baldwin, Susan L, Orr, Mark T, Reese, Valerie A, Pecor, Tiffany, Granger, Brian, Dubois Cauwelaert, Natasha, Podell, Brendan K, Coler, Rhea N

“…It is estimated that one third of the world's population is infected with ( ). This astounding statistic, in combination with costly and lengthy treatment…”
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'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection by Murphy, William J, Orr, Mark T, Lanier, Lewis L

“…The importance of natural killer cell 'licensing' in vivo remains unclear. Lanier and co-workers now report that 'unlicensed' natural killer cells are more…”
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The science of vaccine adjuvants: advances in TLR4 ligand adjuvants by Reed, Steven G, Hsu, Fan-Chi, Carter, Darrick, Orr, Mark T

“…Highlights • Recent advances in TLR4 ligand design are impacting new adjuvants. • Non-glycolipid agonists of TLR4 have potent adjuvant activity. • Adjuvant…”
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Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirus by Orr, Mark T., Beilke, Joshua N., Proekt, Irina, Lanier, Lewis L.

“…Resting natural killer (NK) cells in nonobese diabetic (NOD) mice have impaired immune functions compared with NK cells from other mouse strains. Here we…”
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Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses by Seydoux, Emilie, Liang, Hong, Dubois Cauwelaert, Natasha, Archer, Michelle, Rintala, Nicholas D, Kramer, Ryan, Carter, Darrick, Fox, Christopher B, Orr, Mark T

“…The involvement of innate receptors that recognize pathogen- and danger-associated molecular patterns is critical to programming an effective adaptive immune…”
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Physicochemical structure of a polyacrylic acid stabilized nanoparticle alum (nanoalum) adjuvant governs TH1 differentiation of CD4+ T cells by Khandhar, Amit P, Liang, Hong, Simpson, Adrian C, Reed, Steven G, Carter, Darrick, Fox, Christopher B, Orr, Mark T

“…The growing shift to subunit antigen vaccines underscores the need for adjuvants that can enhance the magnitude and quality of immune response. Aluminum salts…”
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