Search Results - "Orr, David E"
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Design of a Modular Bioreactor to Incorporate Both Perfusion Flow and Hydrostatic Compression for Tissue Engineering Applications
Published in Annals of biomedical engineering (01-07-2008)“…Physiological models have demonstrated that cells undergo a cyclic regimen of hydrostatic compression and fluid shear stress within the lacunar-canalicular…”
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Design and Evaluation of a Novel Flow Chamber for Measuring Cell Adhesion to Absorbable Polymer Films
Published in Biotechnology progress (01-03-2005)“…There is great interest in improving cellular attachment to synthetic materials, particularly for developing small diameter tissue‐engineered vascular grafts…”
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Abstract 3935: A perfused 3D co-culture model of vemurafenib-resistant melanoma
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…Abstract Background: Vemurafenib(VF) is highly active against melanomas with a BRAFV600E mutation. Although remarkable clinical responses occur, progression…”
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Abstract 1102: The 3DKUBE™ segregated co-culture system: optimal tumor-stromal interactions for modeling the tumor microenvironment in anticancer therapeutic development
Published in Cancer research (Chicago, Ill.) (15-04-2013)“…Abstract Background: Better models of the tumor microenvironment (TME) are needed in order to reduce the number of anticancer drug failures in clinical trials…”
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Macrophage incorporation into a 3D perfusion tri-culture model of human breast cancer
Published in Journal for immunotherapy of cancer (04-11-2015)“…BackgroundImmunotherapy has recently shown promising clinical activity in multiple tumor types but standard in vitro immuno-oncology models for preclinical and…”
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