Search Results - "Orozco, J I"

Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors by Llinàs-Arias, Pere, Ensenyat-Mendez, Miquel, Íñiguez-Muñoz, Sandra, Orozco, Javier I J, Valdez, Betsy, Salomon, Matthew P, Matsuba, Chikako, Solivellas-Pieras, Maria, Bedoya-López, Andrés F, Sesé, Borja, Mezger, Anja, Ormestad, Mattias, Unzueta, Fernando, Strand, Siri H, Boiko, Alexander D, Hwang, E Shelley, Cortés, Javier, DiNome, Maggie L, Esteller, Manel, Lupien, Mathieu, Marzese, Diego M

“…Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here…”
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Current Triple-Negative Breast Cancer Subtypes: Dissecting the Most Aggressive Form of Breast Cancer by Ensenyat-Mendez, Miquel, Llinàs-Arias, Pere, Orozco, Javier I. J., Íñiguez-Muñoz, Sandra, Salomon, Matthew P., Sesé, Borja, DiNome, Maggie L., Marzese, Diego M.

“…Triple-negative breast cancer (TNBC) is a highly heterogeneous disease defined by the absence of estrogen receptor (ER) and progesterone receptor (PR)…”
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Epigenetic profiling for the molecular classification of metastatic brain tumors by Orozco, Javier I. J., Knijnenburg, Theo A., Manughian-Peter, Ayla O., Salomon, Matthew P., Barkhoudarian, Garni, Jalas, John R., Wilmott, James S., Hothi, Parvinder, Wang, Xiaowen, Takasumi, Yuki, Buckland, Michael E., Thompson, John F., Long, Georgina V., Cobbs, Charles S., Shmulevich, Ilya, Kelly, Daniel F., Scolyer, Richard A., Hoon, Dave S. B., Marzese, Diego M.

“…Optimal treatment of brain metastases is often hindered by limitations in diagnostic capabilities. To meet this challenge, here we profile DNA methylomes of…”
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Construction and validation of a gene expression classifier to predict immunotherapy response in primary triple-negative breast cancer by Ensenyat-Mendez, Miquel, Orozco, Javier I. J., Llinàs-Arias, Pere, Íñiguez-Muñoz, Sandra, Baker, Jennifer L., Salomon, Matthew P., Martí, Mercè, DiNome, Maggie L., Cortés, Javier, Marzese, Diego M.

“…Background Immune checkpoint inhibitors (ICI) improve clinical outcomes in triple-negative breast cancer (TNBC) patients. However, a subset of patients does…”
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3-D chromatin conformation, accessibility, and gene expression profiling of triple-negative breast cancer by Llinàs-Arias, Pere, Ensenyat-Méndez, Miquel, Orozco, Javier I J, Íñiguez-Muñoz, Sandra, Valdez, Betsy, Wang, Chuan, Mezger, Anja, Choi, Eunkyoung, Tran, Yan Zhou, Yao, Liqun, Bonath, Franziska, Olsen, Remi-André, Ormestad, Mattias, Esteller, Manel, Lupien, Mathieu, Marzese, Diego M

“…Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype with limited treatment options. Unlike other breast cancer subtypes, the…”
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Breast Conservation Project: Clinical Outcomes of Extreme Oncoplastic Breast-Conserving Therapy Versus Mastectomy for Large and Multiple Lesions by Jackson, Katherine M., Millen, Janelle-Cheri, Handy, Nicketti, Orozco, Javier I. J., Stern, Stacey L., Fancher, Crystal E., Grumley, Janie G.

“…Introduction Patients with multiple or large malignant breast lesions are classically considered mastectomy candidates, but extreme oncoplastic…”
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ASO Visual Abstract: Breast Conservation Project: Clinical Outcomes of Extreme Oncoplastic Breast-Conserving Therapy versus Mastectomy for Large and Multiple Lesions by Jackson, Katherine M., Millen, Janelle-Cheri, Handy, Nicketti, Orozco, Javier I. J., Stern, Stacey L., Fancher, Crystal E., Grumley, Janie G.

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Comparing Costs: Does Extreme Oncoplastic Breast-Conserving Surgery Confer a Cost Benefit When Compared with Mastectomy and Reconstruction? by Millen, Janelle-Cheri, Sibia, Udai, Jackson, Katherine, Stern, Stacey L., Orozco, Javier I. J., Fancher, Crystal E., Grumley, Janie

“…Introduction Extreme oncoplastic breast-conserving surgery (eOBCS) describes the application of OBCS to patients who would otherwise need a mastectomy, and its…”
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ASO Visual Abstract: Comparing Costs—Does Extreme Oncoplastic Breast-Conserving Surgery Confer a Cost Benefit When Compared with Mastectomy and Reconstruction? by Millen, Janelle-Cheri, Sibia, Udai, Jackson, Katherine, Stern, Stacey L., Orozco, Javier I. J., Fancher, Crystal E., Grumley, Janie

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Correction: Comparing Costs: Does Extreme Oncoplastic Breast-Conserving Surgery Confer a Cost Benefit When Compared with Mastectomy and Reconstruction? by Millen, Janelle-Cheri, Sibia, Udai, Jackson, Katherine, Stern, Stacey L., Orozco, Javier I. J., Fancher, Crystal E., Grumley, Janie

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ASO Author Reflections: Molecular Testing in Breast Cancer: Is Core Biopsy Equivalent to Surgical Specimen? by Orozco, Javier I. J., Grumley, Janie G.

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Impact of Locoregional Treatment on Survival in Young Patients with Early-Stage Breast Cancer undergoing Upfront Surgery by Orozco, Javier I. J., Keller, Jennifer K., Chang, Shu-Ching, Fancher, Crystal E., Grumley, Janie G.

“…Background Randomized, controlled trials comparing breast-conserving therapy (BCT) with mastectomy have demonstrated equivalent overall survival (OS), but…”
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Simultaneous Symmetry Procedure in Patients Undergoing Oncoplastic Breast-Conserving Surgery: An Evaluation of Patient Desire and Revision Rates by Millen, Janelle-Cheri, Jackson, Katherine M., Stern, Stacey L., Orozco, Javier I. J., Fancher, Crystal E., Grumley, Janie

“…Introduction In the era of oncoplastic breast conserving-surgery (OBCS), cosmetic outcomes and the desire for symmetry have become essential elements of the…”
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ASO Author Reflections: Breast-Conserving Therapy: A Safe Option in Young Patients with Early-Stage Breast Cancer by Orozco, Javier I. J., Fancher, Crystal E., Grumley, Janie G.

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Biological effects of intraoperative radiation therapy: histopathological changes and immunomodulation in breast cancer patients by Orozco, Javier I J, Valdez, Betsy J, Matsuba, Chikako, Simanonok, Michael P, Ensenyat-Mendez, Miquel, Ramiscal, Judi Anne B, Salomon, Matthew P, Takasumi, Yuki, Grumley, Janie G

“…Intraoperative radiation therapy (IORT) delivers a single accelerated radiation dose to the breast tumor bed during breast-conserving surgery (BCS). The…”
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Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements by Iñiguez-Muñoz, Sandra, Llinàs-Arias, Pere, Ensenyat-Mendez, Miquel, Bedoya-López, Andrés F., Orozco, Javier I. J., Cortés, Javier, Roy, Ananya, Forsberg-Nilsson, Karin, DiNome, Maggie L., Marzese, Diego M.

“…Discoveries in the field of genomics have revealed that non-coding genomic regions are not merely "junk DNA", but rather comprise critical elements involved in…”
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Epigenetic Signatures Predict Pathologic Nodal Stage in Breast Cancer Patients with Estrogen Receptor-Positive, Clinically Node-Positive Disease by Ensenyat-Mendez, Miquel, Rünger, Dennis, Orozco, Javier I. J., Le, Julie, Baker, Jennifer L., Weidhaas, Joanne, Marzese, Diego M., DiNome, Maggie L.

“…Background Breast cancer patients with clinically positive nodes who undergo upfront surgery are often recommended for axillary lymph node dissection (ALND),…”
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ASO Author Reflections: Molecular Signatures May Render Surgical Staging of the Axilla Obsolete by Orozco, Javier I. J., Le, Julie, Baker, Jennifer L., Marzese, Diego M., DiNome, Maggie L.

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ASO Visual Abstract: Epigenetic Signatures Predict Pathologic Nodal Stage in Breast Cancer Patients with Estrogen-Receptor-Positive, Clinically Node-Positive Disease by Ensenyat-Mendez, Miquel, Rünger, Dennis, Orozco, Javier I. J., Le, Julie, Baker, Jennifer L., Weidhaas, Joanne, Marzese, Diego M., DiNome, Maggie L.

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A Look at the Other Side: High-Risk Lesions and Occult Contralateral Malignancy in Symmetry Procedures for Patients Undergoing Oncoplastic Breast-Conserving Surgery by Jackson, Katherine M., Millen, Janelle-Cheri, Orozco, Javier I. J., Stern, Stacey L., Fancher, Crystal E., Grumley, Janie G.

“…Background The incidence of occult breast cancer among patients undergoing reduction mammoplasty or risk-reducing mastectomies ranges from 1% to approximately…”
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