Search Results - "Orozco, Ian"

Structures of human pannexin 1 reveal ion pathways and mechanism of gating by Ruan, Zheng, Orozco, Ian J., Du, Juan, Lü, Wei

“…Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of physiological functions such as blood pressure regulation 1 , apoptotic cell…”
Get full text

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake by Ren, Hongxia, Orozco, Ian J., Su, Ya, Suyama, Shigetomo, Gutiérrez-Juárez, Roger, Horvath, Tamas L., Wardlaw, Sharon L., Plum, Leona, Arancio, Ottavio, Accili, Domenico

“…Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating food intake, but druggable biochemical pathways that control this…”
Get full text

A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism by Fernandes-Rosa, Fabio L., Daniil, Georgios, Orozco, Ian J., Göppner, Corinna, El Zein, Rami, Jain, Vandana, Boulkroun, Sheerazed, Jeunemaitre, Xavier, Amar, Laurence, Lefebvre, Hervé, Schwarzmayr, Thomas, Strom, Tim M., Jentsch, Thomas J., Zennaro, Maria-Christina

“…Primary aldosteronism is the most common and curable form of secondary arterial hypertension. We performed whole-exome sequencing in patients with early-onset…”
Get full text

Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition by Ruan, Zheng, Haley, Emery, Orozco, Ian J., Sabat, Mark, Myers, Richard, Roth, Rebecca, Du, Juan, Lü, Wei

“…The Ca 2+ -activated TRPM5 channel plays essential roles in taste perception and insulin secretion. However, the mechanism by which Ca 2+ regulates TRPM5…”
Get full text

Physiological temperature drives TRPM4 ligand recognition and gating by Hu, Jinhong, Park, Sung Jin, Walter, Tyler, Orozco, Ian J., O‘Dea, Garrett, Ye, Xinyu, Du, Juan, Lü, Wei

“…Temperature profoundly affects macromolecular function, particularly in proteins with temperature sensitivity 1 , 2 . However, its impact is often overlooked…”
Get full text

Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism by Göppner, Corinna, Orozco, Ian J., Hoegg-Beiler, Maja B., Soria, Audrey H., Hübner, Christian A., Fernandes-Rosa, Fabio L., Boulkroun, Sheerazed, Zennaro, Maria-Christina, Jentsch, Thomas J.

“…Human primary aldosteronism (PA) can be caused by mutations in several ion channel genes but mouse models replicating this condition are lacking. We now show…”
Get full text

Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction by Hoegg-Beiler, Maja B., Sirisi, Sònia, Orozco, Ian J., Ferrer, Isidre, Hohensee, Svea, Auberson, Muriel, Gödde, Kathrin, Vilches, Clara, de Heredia, Miguel López, Nunes, Virginia, Estévez, Raúl, Jentsch, Thomas J.

“…Defects in the astrocytic membrane protein MLC1, the adhesion molecule GlialCAM or the chloride channel ClC-2 underlie human leukoencephalopathies. Whereas…”
Get full text

Author Correction: Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition by Ruan, Zheng, Haley, Emery, Orozco, Ian J., Sabat, Mark, Myers, Richard, Roth, Rebecca, Du, Juan, Lü, Wei

Get full text

Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease by Lee, Linda, Dale, Elena, Staniszewski, Agnes, Zhang, Hong, Saeed, Faisal, Sakurai, Mikako, Fa', Mauro, Orozco, Ian, Michelassi, Francesco, Akpan, Nsikan, Lehrer, Helaina, Arancio, Ottavio

“…Learning and memory and the underlying cellular correlate, long-term synaptic plasticity, involve regulation by posttranslational modifications (PTMs). Here we…”
Get full text

Loss of the Intermembrane Space Protein Mgm1/OPA1 Induces Swelling and Localized Constrictions along the Lengths of Mitochondria by Griparic, Lorena, van der Wel, Nicole N, Orozco, Ian J, Peters, Peter J, van der Bliek, Alexander M

“…Mgm1 is a member of the dynamin family of GTP-binding proteins. Mgm1 was first identified in yeast, where it affects mitochondrial morphology. The human…”
Get full text

The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice by Orozco, Ian J., Koppensteiner, Peter, Ninan, Ipe, Arancio, Ottavio

“…The dystrobrevin binding protein (DTNBP) 1 gene has emerged over the last decade as a potential susceptibility locus for schizophrenia. While no causative…”
Get full text

A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment by Liu, Li, Orozco, Ian J, Planel, Emmanuel, Wen, Yi, Bretteville, Alexis, Krishnamurthy, Pavan, Wang, Lili, Herman, Mathieu, Figueroa, Helen, Yu, W. Haung, Arancio, Ottavio, Duff, Karen

“…Abstract In the last decade, multiple lines of transgenic APP overexpressing mice have been created that recapitulate certain aspects of Alzheimer's disease…”
Get full text

KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors by Schütze, Sebastian, Orozco, Ian J., Jentsch, Thomas J.

“…M-current-mediating KCNQ (Kv7) channels play an important role in regulating the excitability of neuronal cells, as highlighted by mutations in Kcnq2 and Kcnq3…”
Get full text

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake by Ren, Hongxia, Orozco, Ian J., Su, Ya, Suyama, Shigetomo, Gutiérrez-Juárez, Roger, Horvath, Tamas L., Wardlaw, Sharon L., Plum, Leona, Arancio, Ottavio, Accili, Domenico

Get full text

Radiofrequency Ablation of Recurrent Metastatic Papillary Thyroid Cancer to a Lymph Node by Ahmad, Shahzad, Orozco, Ian James, Raashid, Sheheryar, Hamid, Zainab, Aljammal, Jules

Get full text

Preparation of oligomeric beta-amyloid 1-42 and induction of synaptic plasticity impairment on hippocampal slices by Fa, Mauro, Orozco, Ian J, Francis, Yitshak I, Saeed, Faisal, Gong, Yimin, Arancio, Ottavio

“…Impairment of synaptic connections is likely to underlie the subtle amnesic changes occurring at the early stages of Alzheimer s Disease (AD). beta-amyloid (A…”
Get full text

Enhanced spontaneous release of neurotransmitter underlies early changes in synaptic function by beta-amyloid by Fa, Mauro, Leznik, Elena, Ninan, Ipe, Trinchese, Fabrizio, Liu, Shumin, Orozco, Ian J, Koppensteiner, Peter, Arancio, Ottavio

Get full text

The Poly(A) Signal, without the Assistance of Any Downstream Element, Directs RNA Polymerase II to Pause in Vivo and Then to Release Stochastically from the Template by Orozco, Ian J, Kim, Steven J, Martinson, Harold G

“…Genes encoding polyadenylated mRNAs depend on their poly(A) signals for termination of transcription. Typically, transcription downstream of the poly(A) signal…”
Get full text

Ion pathways in the human pannexin 1 channel by Orozco, Ian J., Ruan, Zheng, Du, Juan, Lu, Wei

Get full text

Structural and Functional Investigation on Human Pannexin 1 (PANX1) Reveals Novel Insight Into Channel Gating, Ion Permeation and Drug Inhibition by Ruan, Zheng, Ian, Orozco J., Du, Juan, Lu, Wei

Get full text