Effect of hyperbaric oxygen therapy on cerebral vasospasm: a vascular morphometric study in an experimental subarachnoid hemorrhage model

This study was undertaken to investigate the preventive or therapeutic effect of hyperbaric oxygen therapy (HBOT) on cerebral vasospasm following experimental subarachnoid hemorrhage (SAH). Twenty rabbits were assigned randomly to one of four groups. Animals in Group I were not subjected to SAH or s...

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Bibliographic Details
Published in:	International journal of neuroscience Vol. 124; no. 8; pp. 593 - 600
Main Authors:	Çelik, Özgür, Bay, Hüsniye Hac o lu, Arslanhan, Ayça, Oro lu, Bengüsu, Bozkurt, Süheyla Uyar, ehirli, Ümit Süleyman, Ziyal, Mustafa brahim
Format:	Journal Article
Language:	English
Published:	England Informa Healthcare 03-08-2014 Taylor & Francis
Subjects:	Animals Cerebral vasospasm Disease Models, Animal hyperbaric oxygen Hyperbaric Oxygenation - methods Male Rabbits Random Allocation subarachnoid hemorrhage Subarachnoid Hemorrhage - metabolism Subarachnoid Hemorrhage - pathology Subarachnoid Hemorrhage - therapy Treatment Outcome vascular morphometry vasospasm index Vasospasm, Intracranial - metabolism Vasospasm, Intracranial - pathology Vasospasm, Intracranial - therapy wall thickness Cerebral vasospasm hyperbaric oxygen vascular morphometry wall thickness subarachnoid hemorrhage vasospasm index
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Summary:	This study was undertaken to investigate the preventive or therapeutic effect of hyperbaric oxygen therapy (HBOT) on cerebral vasospasm following experimental subarachnoid hemorrhage (SAH). Twenty rabbits were assigned randomly to one of four groups. Animals in Group I were not subjected to SAH or sham operation (control group, n = 5). Animals in Group II were subjected to sham operation and received no treatment after the procedure (sham group, n = 5). Animals in Group III were subjected to SAH and received no treatment after SAH induction (SAH group, n = 5). Animals in Group IV were subjected to SAH and received five sessions of HBOT at 2.4 atmospheres absolute (ATA) for 2 h (treatment group, n = 5). Animals were euthanized by perfusion and fixation 72 h after procedures. Basilar artery vasospasm indices, arterial wall thicknesses, and cross-sectional luminal areas were evaluated. Statistical comparisons were performed using Kruskal-Wallis and Mann-Whitney U tests. Mean basilar artery vasospasm index in the treatment group was significantly smaller than in the SAH group. Mean basilar artery wall thickness in the treatment group was significantly smaller than in the SAH group. Mean basilar artery cross-sectional luminal area in the treatment group showed an increase relative to the SAH group, but this difference remained statistically insignificant. Our results demonstrated that repeated application of HBOT at 2.4 ATA for 2 h attenuated vasospastic changes such as increased vasospasm index and arterial wall thickness. HBOT is thus a promising candidate for SAH-induced vasospasm. Further studies are needed to evaluate maximal effect and optimal application regimen.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0020-7454 1563-5279 1543-5245
DOI:	10.3109/00207454.2013.865619