Search Results - "Oro, Anthony E."

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma by Atwood, Scott X., Sarin, Kavita Y., Whitson, Ramon J., Li, Jiang R., Kim, Geurim, Rezaee, Melika, Ally, Mina S., Kim, Jinah, Yao, Catherine, Chang, Anne Lynn S., Oro, Anthony E., Tang, Jean Y.

“…Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations…”
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An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib by Danial, Christina, Sarin, Kavita Y, Oro, Anthony E, Chang, Anne Lynn S

“…To assess the tumor response to the smoothened (SMO) inhibitor, sonidegib (LDE225), in patients with an advanced basal cell carcinoma (BCC) resistant to…”
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Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma by Sekulic, Aleksandar, Migden, Michael R, Oro, Anthony E, Dirix, Luc, Lewis, Karl D, Hainsworth, John D, Solomon, James A, Yoo, Simon, Arron, Sarah T, Friedlander, Philip A, Marmur, Ellen, Rudin, Charles M, Chang, Anne Lynn S, Low, Jennifer A, Mackey, Howard M, Yauch, Robert L, Graham, Richard A, Reddy, Josina C, Hauschild, Axel

“…In this international, nonrandomized study, vismodegib, an oral inhibitor of the ligand that activates the hedgehog pathway, showed responses in patients with…”
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Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop by Woo, Wei-Meng, Zhen, Hanson H, Oro, Anthony E

“…During hair follicle morphogenesis, dermal papillae (DPs) function as mesenchymal signaling centers that cross-talk with overlying epithelium to regulate…”
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Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition by Tang, Yujie, Gholamin, Sharareh, Schubert, Simone, Willardson, Minde I, Lee, Alex, Bandopadhayay, Pratiti, Bergthold, Guillame, Masoud, Sabran, Nguyen, Brian, Vue, Nujsaubnusi, Balansay, Brianna, Yu, Furong, Oh, Sekyung, Woo, Pamelyn, Chen, Spenser, Ponnuswami, Anitha, Monje, Michelle, Atwood, Scott X, Whitson, Ramon J, Mitra, Siddhartha, Cheshier, Samuel H, Qi, Jun, Beroukhim, Rameen, Tang, Jean Y, Wechsler-Reya, Rob, Oro, Anthony E, Link, Brian A, Bradner, James E, Cho, Yoon-Jae

“…Cancers dependent on hedgehog pathway signaling are susceptible to the BET bromodomain inhibitor JQ1. Hedgehog signaling drives oncogenesis in several cancers,…”
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AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma by Yao, Catherine D., Haensel, Daniel, Gaddam, Sadhana, Patel, Tiffany, Atwood, Scott X., Sarin, Kavita Y., Whitson, Ramon J., McKellar, Siegen, Shankar, Gautam, Aasi, Sumaira, Rieger, Kerri, Oro, Anthony E.

“…Tumor heterogeneity and lack of knowledge about resistant cell states remain a barrier to targeted cancer therapies. Basal cell carcinomas (BCCs) depend on…”
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RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors by Zhao, Xuesong, Ponomaryov, Tatyana, Ornell, Kimberly J, Zhou, Pengcheng, Dabral, Sukriti K, Pak, Ekaterina, Li, Wei, Atwood, Scott X, Whitson, Ramon J, Chang, Anne Lynn S, Li, Jiang, Oro, Anthony E, Chan, Jennifer A, Kelleher, Joseph F, Segal, Rosalind A

“…Aberrant Shh signaling promotes tumor growth in diverse cancers. The importance of Shh signaling is particularly evident in medulloblastoma and basal cell…”
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Actin polymerization controls cilia-mediated signaling by Drummond, Michael L, Li, Mischa, Tarapore, Eric, Nguyen, Tuyen T L, Barouni, Baina J, Cruz, Shaun, Tan, Kevin C, Oro, Anthony E, Atwood, Scott X

“…Primary cilia are polarized organelles that allow detection of extracellular signals such as Hedgehog (Hh). How the cytoskeleton supporting the cilium…”
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Hedgehog pathway inhibition and the race against tumor evolution by Atwood, Scott X, Chang, Anne Lynn S, Oro, Anthony E

“…Dependence of basal cell carcinomas and medulloblastomas on the Hedgehog pathway provides an opportunity for targeted or "personalized" therapy. The recent…”
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Basal-to-inflammatory transition and tumor resistance via crosstalk with a pro-inflammatory stromal niche by Li, Nancy Yanzhe, Zhang, Weiruo, Haensel, Daniel, Jussila, Anna R., Pan, Cory, Gaddam, Sadhana, Plevritis, Sylvia K., Oro, Anthony E.

“…Cancer-associated inflammation is a double-edged sword possessing both pro- and anti-tumor properties through ill-defined tumor-immune dynamics. While we…”
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Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas by Whitson, Ramon J, Lee, Alex, Urman, Nicole M, Mirza, Amar, Yao, Catherine Y, Brown, Alexander S, Li, Jiang R, Shankar, Gautam, Fry, Micah A, Atwood, Scott X, Lee, Eunice Y, Hollmig, S Tyler, Aasi, Sumaira Z, Sarin, Kavita Y, Scott, Matthew P, Epstein, Ervin H, Tang, Jean Y, Oro, Anthony E

“…A large proportion of basal cell carcinomas develop resistance independently of the canonical mutations in genes encoding hedgehog pathway components. An…”
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A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs by Shue, Yan Ting, Drainas, Alexandros P., Li, Nancy Yanzhe, Pearsall, Sarah M., Morgan, Derrick, Sinnott-Armstrong, Nasa, Hipkins, Susan Q., Coles, Garry L., Lim, Jing Shan, Oro, Anthony E., Simpson, Kathryn L., Dive, Caroline, Sage, Julien

“…The Notch pathway is a conserved cell-cell communication pathway that controls cell fate decisions. Here we sought to determine how Notch pathway activation…”
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TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment by Li, Lingjie, Wang, Yong, Torkelson, Jessica L., Shankar, Gautam, Pattison, Jillian M., Zhen, Hanson H., Fang, Fengqin, Duren, Zhana, Xin, Jingxue, Gaddam, Sadhana, Melo, Sandra P., Piekos, Samantha N., Li, Jiang, Liaw, Eric J., Chen, Lang, Li, Rui, Wernig, Marius, Wong, Wing H., Chang, Howard Y., Oro, Anthony E.

“…Tissue development results from lineage-specific transcription factors (TFs) programming a dynamic chromatin landscape through progressive cell fate…”
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Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche by Haensel, Daniel, Daniel, Bence, Gaddam, Sadhana, Pan, Cory, Fabo, Tania, Bjelajac, Jeremy, Jussila, Anna R., Gonzalez, Fernanda, Li, Nancy Yanzhe, Chen, Yun, Hou, JinChao, Patel, Tiffany, Aasi, Sumaira, Satpathy, Ansuman T., Oro, Anthony E.

“…Cancer immunotherapies have revolutionized treatment but have shown limited success as single-agent therapies highlighting the need to understand the origin,…”
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Loss of Primary Cilia Drives Switching from Hedgehog to Ras/MAPK Pathway in Resistant Basal Cell Carcinoma by Kuonen, François, Huskey, Noelle E., Shankar, Gautam, Jaju, Prajakta, Whitson, Ramon J., Rieger, Kerri E., Atwood, Scott X., Sarin, Kavita Y., Oro, Anthony E.

“…Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naive…”
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MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling by Bershteyn, Marina, Atwood, Scott X., Woo, Wei-Meng, Li, Mischa, Oro, Anthony E.

“…The primary cilium is critical for transducing Sonic hedgehog (Shh) signaling, but the mechanisms of its transient assembly are poorly understood. Previously…”
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LY6D marks pre-existing resistant basosquamous tumor subpopulations by Haensel, Daniel, Gaddam, Sadhana, Li, Nancy Y., Gonzalez, Fernanda, Patel, Tiffany, Cloutier, Jeffrey M., Sarin, Kavita Y., Tang, Jean Y., Rieger, Kerri E., Aasi, Sumaira Z., Oro, Anthony E.

“…Improved response to canonical therapies requires a mechanistic understanding of dynamic tumor heterogeneity by identifying discrete cellular populations with…”
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Biomedical Data Commons (BMDC) prioritizes B-lymphocyte non-coding genetic variants in Type 1 Diabetes by Piekos, Samantha N, Gaddam, Sadhana, Bhardwaj, Pranav, Radhakrishnan, Prashanth, Guha, Ramanathan V, Oro, Anthony E

“…The repurposing of biomedical data is inhibited by its fragmented and multi-formatted nature that requires redundant investment of time and resources by data…”
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Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant by Melo, Sandra P, Lisowski, Leszek, Bashkirova, Elizaveta, Zhen, Hanson H, Chu, Kirk, Keene, Douglas R, Marinkovich, M Peter, Kay, Mark A, Oro, Anthony E

“…Definitive correction of disease causing mutations in somatic cells by homologous recombination (HR) is an attractive therapeutic approach for the treatment of…”
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Bone Morphogenetic Protein Antagonist Gremlin 1 Is Widely Expressed by Cancer-Associated Stromal Cells and Can Promote Tumor Cell Proliferation by Sneddon, Julie B., Zhen, Hanson H., Montgomery, Kelli, van de Rijn, Matt, Tward, Aaron D., West, Robert, Gladstone, Hayes, Chang, Howard Y., Morganroth, Greg S., Oro, Anthony E., Brown, Patrick O.

“…Although tissue microenvironments play critical roles in epithelial development and tumorigenesis, the factors mediating these effects are poorly understood…”
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