Search Results - "Orner, Brendan P."

Self-assembly in the ferritin nano-cage protein superfamily by Zhang, Yu, Orner, Brendan P

“…Protein self-assembly, through specific, high affinity, and geometrically constraining protein-protein interactions, can control and lead to complex cellular…”
Get full text

Design and Applications of Protein-Cage-Based Nanomaterials by Zhang, Yu, Ardejani, Maziar S., Orner, Brendan P.

“…Materials science is beginning to focus on biotemplation, and in support of that trend, it is realized that protein cages—proteins that assemble from multiple…”
Get full text

Designability of Aromatic Interaction Networks at E. coli Bacterioferritin B-Type Channels by Zhang, Yu, Zhou, Jinhua, Ardejani, Maziar S, Li, Xun, Wang, Fei, Orner, Brendan P

“…The bacterioferritin from (BFR), a maxi-ferritin made of 24 subunits, has been utilized as a model to study the fundamentals of protein folding and…”
Get full text

Complete shift of ferritin oligomerization toward nanocage assembly via engineered protein-protein interactions by Ardejani, Maziar S, Chok, Xiao Ling, Foo, Ce Jin, Orner, Brendan P

“…Computational redesign of a dimorphic protein nano-cage at the C3-symmetrical interfaces forces it to assemble into the monomorphic cage. These monodisperse…”
Get more information

Mutagenesis study to disrupt electrostatic interactions on the twofold symmetry interface of Escherichia coli bacterioferritin by Zhang, Yu, Wang, Lijun, Ardejani, Maziar S, Aris, Nur Fazlina, Li, Xun, Orner, Brendan P, Wang, Fei

“…Ferritins and other cage proteins have been utilized as models to understand the fundamentals of protein folding and self-assembly. The bacterioferritin (BFR)…”
Get full text

Defined Substrates for Human Embryonic Stem Cell Growth Identified from Surface Arrays by Derda, Ratmir, Li, Lingyin, Orner, Brendan P, Lewis, Rachel L, Thomson, James A, Kiessling, Laura L

“…Methods for the rapid identification of defined cell growth conditions are lacking. This deficiency is a major barrier to the investigation and application of…”
Get full text

Rational disruption of the oligomerization of the mini‐ferritin E. coli DPS through protein‐protein interface mutation by Zhang, Yu, Fu, Jing, Chee, Sze Y., Ang, Emmiline X. W., Orner, Brendan P.

“…DNA‐binding protein from starved cells (DPS), a mini‐ferritin capable of self‐assembling into a 12‐meric nano‐cage, was chosen as the basis for an…”
Get full text

Arrays for the Combinatorial Exploration of Cell Adhesion by Orner, Brendan P, Derda, Ratmir, Lewis, Rachel L, Thomson, James A, Kiessling, Laura L

“…A new method for the fabrication of arrays of self-assembled monolayers (SAMs) of alkane thiols (ATs) on gold to combinatorially assay surfaces for cell…”
Get full text

The discovery of small-molecule mimicking peptides through phage display by Dudak, Fahriye Ceyda, Boyaci, Ismail Hakki, Orner, Brendan P

“…Using peptides to achieve the functional and structural mimicry of small-molecules, especially those with biological activity or clear biotechnological…”
Get full text

A Versatile One-Pot Synthesis of 1,3-Substituted Guanidines from Carbamoyl Isothiocyanates by Linton, Brian R, Carr, Andrew J, Orner, Brendan P, Hamilton, Andrew D

Get full text

High-Throughput Discovery of Synthetic Surfaces That Support Proliferation of Pluripotent Cells by Derda, Ratmir, Musah, Samira, Orner, Brendan P, Klim, Joseph R, Li, Lingyin, Kiessling, Laura L

“…Synthetic materials that promote the growth or differentiation of cells have advanced the fields of tissue engineering and regenerative medicine. Most…”
Get full text

The Crystal Structure of a Maxi/Mini-Ferritin Chimera Reveals Guiding Principles for the Assembly of Protein Cages by Cornell, Thomas A, Srivastava, Yogesh, Jauch, Ralf, Fan, Rongli, Orner, Brendan P

“…Cage proteins assemble into nanoscale structures with large central cavities. They play roles, including those as virus capsids and chaperones, and have been…”
Get full text

A Structure-Based Assembly Screen of Protein Cage Libraries in Living Cells: Experimentally Repacking a Protein–Protein Interface To Recover Cage Formation in an Assembly-Frustrated Mutant by Cornell, Thomas A, Ardejani, Maziar S, Fu, Jing, Newland, Stephanie H, Zhang, Yu, Orner, Brendan P

“…Cage proteins, which assemble into often highly symmetric hollow nanoscale capsules, have great potential in applications as far reaching as drug delivery,…”
Get full text

Modular peptides from the thermoplastic squid sucker ring teeth form amyloid-like cross-β supramolecular networks by Hiew, Shu Hui, Guerette, Paul A., Zvarec, Ondrej J., Phillips, Margaret, Zhou, Feng, Su, Haibin, Pervushin, Konstantin, Orner, Brendan P., Miserez, Ali

“…[Display omitted] The hard sucker ring teeth (SRT) from decapodiforme cephalopods, which are located inside the sucker cups lining the arms and tentacles of…”
Get full text

Obey the Peptide Assembly Rules by Ardejani, Maziar S., Orner, Brendan P.

“…Application of simple design rules enables controlled assembly of discrete peptide nanostructures. [Also see Report by Fletcher et al. ] The complex properties…”
Get full text

Detection of Specific Protein–Protein Interactions in Nanocages by Engineering Bipartite FlAsH Binding Sites by Cornell, Thomas A, Fu, Jing, Newland, Stephanie H, Orner, Brendan P

“…Proteins that form cage-like structures have been of much recent cross-disciplinary interest due to their application to bioconjugate and materials chemistry,…”
Get full text

Stabilization of a Protein Nanocage through the Plugging of a Protein–Protein Interfacial Water Pocket by Ardejani, Maziar S, Li, Noel X, Orner, Brendan P

“…The unique structural properties of the ferritin protein cages have provided impetus to focus on the methodical study of these self-assembling nanosystems…”
Get full text

Terphenyl-Based Bak BH3 α-Helical Proteomimetics as Low-Molecular-Weight Antagonists of Bcl-xL by Yin, Hang, Lee, Gui-in, Sedey, Kristine A, Kutzki, Olaf, Park, Hyung Soon, Orner, Brendan P, Ernst, Justin T, Wang, Hong-Gang, Sebti, Said M, Hamilton, Andrew D

“…We describe a general method for the mimicry of one face of an α-helix based on a terphenyl scaffold that spatially projects functionality in a manner similar…”
Get full text

Development of a Potent Bcl-xL Antagonist Based on α-Helix Mimicry by Kutzki, Olaf, Park, Hyung Soon, Ernst, Justin T, Orner, Brendan P, Yin, Hang, Hamilton, Andrew D

“…The rational design of low-molecular weight ligands that disrupt protein−protein interactions is still a challenging goal in medicinal chemistry. Our approach…”
Get full text

A Helix Swapping Study of Two Protein Cages by Fan, Rongli, Boyle, Aimee L, Cheong, Vee Vee, Ng, See Liang, Orner, Brendan P

“…Protein cages have been the focus of studies across multiple scientific disciplines. They have been used to deliver drugs, as templates for nanostructured…”
Get full text