Search Results - "Ormsby, Tereza"
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ASH1-catalyzed H3K36 methylation drives gene repression and marks H3K27me2/3-competent chromatin
Published in eLife (23-11-2018)“…Methylation of histone H3 at lysine 36 (H3K36me), a widely-distributed chromatin mark, largely results from association of the lysine methyltransferase (KMT)…”
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Telomere repeats induce domains of H3K27 methylation in Neurospora
Published in eLife (03-01-2018)“…Development in higher organisms requires selective gene silencing, directed in part by di-/trimethylation of lysine 27 on histone H3 (H3K27me2/3). Knowledge of…”
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LSD1 prevents aberrant heterochromatin formation in Neurospora crassa
Published in Nucleic acids research (09-10-2020)“…Abstract Heterochromatin is a specialized form of chromatin that restricts access to DNA and inhibits genetic processes, including transcription and…”
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Nucleosome Positioning by an Evolutionarily Conserved Chromatin Remodeler Prevents Aberrant DNA Methylation in Neurospora
Published in Genetics (Austin) (01-02-2019)“…In the filamentous fungus , constitutive heterochromatin is marked by tri-methylation of histone H3 lysine 9 (H3K9me3) and DNA methylation. We identified…”
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Marked Neurospora crassa Strains for Competition Experiments and Bayesian Methods for Fitness Estimates
Published in G3 : genes - genomes - genetics (01-04-2020)“…The filamentous fungus , a model microbial eukaryote, has a life cycle with many features that make it suitable for studying experimental evolution. However,…”
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Evolutionarily ancient BAH–PHD protein mediates Polycomb silencing
Published in Proceedings of the National Academy of Sciences - PNAS (26-05-2020)“…Methylation of histone H3 lysine 27 (H3K27) is widely recognized as a transcriptionally repressive chromatin modification but the mechanism of repression…”
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Polymer-based antibody mimetics (iBodies) target human PD-L1 and function as a potent immune checkpoint blocker
Published in The Journal of biological chemistry (01-06-2024)“…Immune checkpoint blockade (ICB) using monoclonal antibodies against programmed cell death protein 1 (PD-1) or programmed death-ligand 1 (PD-L1) is the…”
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Normal chromosome conformation depends on subtelomeric facultative heterochromatin in Neurospora crassa
Published in Proceedings of the National Academy of Sciences - PNAS (27-12-2016)“…High-throughput chromosome conformation capture (Hi-C) analyses revealed that the 3D structure of the Neurospora crassa genome is dominated by intra- and…”
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Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with α-ketoamide warheads
Published in European journal of medicinal chemistry (15-11-2021)“…Peptidomimetic inhibitors of fibroblast activation protein (FAP) are regarded as promising tools for tumor targeting in vivo. Even though several…”
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Control of Development, Secondary Metabolism and Light-Dependent Carotenoid Biosynthesis by the Velvet Complex of Neurospora crassa
Published in Genetics (Austin) (01-07-2019)“…is an established reference organism to investigate carotene biosynthesis and light regulation. However, there is little evidence of its capacity to produce…”
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LST1/A Is a Myeloid Leukocyte-specific Transmembrane Adaptor Protein Recruiting Protein Tyrosine Phosphatases SHP-1 and SHP-2 to the Plasma Membrane
Published in The Journal of biological chemistry (29-06-2012)“…Transmembrane adaptor proteins are membrane-anchored proteins consisting of a short extracellular part, a transmembrane domain, and a cytoplasmic part with…”
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Btk is a positive regulator in the TREM-1/DAP12 signaling pathway
Published in Blood (28-07-2011)“…The triggering receptor expressed on myeloid cells 1 (TREM-1) has been implicated in the production of proinflammatory cytokines and chemokines during…”
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Control of Development, Secondary Metabolism and Light-Dependent Carotenoid Biosynthesis by the Velvet Complex of Neurospora crassa
Published in Genetics (Austin) (01-07-2019)“…Neurospora crassa is an established reference organism to investigate carotene biosynthesis and light regulation. However, there is little evidence of its…”
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Control of Development, Secondary Metabolism and Light-Dependent Carotenoid Biosynthesis by the Velvet Complex of Neurospora crassa
Published in Genetics (Austin) (01-07-2019)“…Neurospora crassa is an established reference organism to investigate carotene biosynthesis and light regulation. However, there is little evidence of its…”
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PRR7 Is a Transmembrane Adaptor Protein Expressed in Activated T Cells Involved in Regulation of T Cell Receptor Signaling and Apoptosis
Published in The Journal of biological chemistry (03-06-2011)“…Transmembrane adaptor proteins (TRAPs) are important organizers and regulators of immunoreceptor-mediated signaling. A bioinformatic search revealed several…”
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