Search Results - "Orme, Ian M"

Host response to nontuberculous mycobacterial infections of current clinical importance by Orme, Ian M, Ordway, Diane J

“…The nontuberculous mycobacteria are a large group of acid-fast bacteria that are very widely distributed in the environment. While Mycobacterium avium was once…”
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Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens by Qualls, Joseph E, Pesce, John T, Tuomanen, Elaine I, Orme, Ian M, Murray, Peter J, Kanneganti, Thirumala-Devi, Fitzgerald, Katherine A, Kaplan, Gilla, König, Till, Henao-Tamayo, Marcela, Schleicher, Ulrike, Bogdan, Christian, Koo, Mi-Sun, Basaraba, Randall J, Smith, Amber M, Wynn, Thomas A, El Kasmi, Karim C, Thompson, Robert W

“…Classically activated macrophages are targets of intracellular bacteria such as Mycobacteria tuberculosis . Murray and colleagues find that such pathogens…”
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A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis by Sweeney, Kari A, Dao, Dee N, Goldberg, Michael F, Hsu, Tsungda, Venkataswamy, Manjunatha M, Henao-Tamayo, Marcela, Ordway, Diane, Sellers, Rani S, Jain, Paras, Chen, Bing, Chen, Mei, Kim, John, Lukose, Regy, Chan, John, Orme, Ian M, Porcelli, Steven A, Jacobs, William R

“…New vaccine candidates are urgently needed for the control and prevention of Mycobacterium tuberculosis (Mtb) infection. Kari Sweeney and her colleagues now…”
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Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity by Sun, Jim, Singh, Vijender, Lau, Alice, Stokes, Richard W, Obregón-Henao, Andrés, Orme, Ian M, Wong, Dennis, Av-Gay, Yossef, Hmama, Zakaria

“…Defining the mechanisms of Mycobacterium tuberculosis (Mtb) persistence in the host macrophage and identifying mycobacterial factors responsible for it are…”
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Gr1(int)CD11b+ myeloid-derived suppressor cells in Mycobacterium tuberculosis infection by Obregón-Henao, Andrés, Henao-Tamayo, Marcela, Orme, Ian M, Ordway, Diane J

“…Tuberculosis is one of the world's leading killers, stealing 1.4 million lives and causing 8.7 million new and relapsed infections in 2011. The only vaccine…”
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Location of Persisting Mycobacteria in a Guinea Pig Model of Tuberculosis Revealed by R207910 by LENAERTS, Anne J, HOFF, Donald, ALY, Sahar, EHLERS, Stefan, ANDRIES, Koen, CANTARERO, Luis, ORME, Ian M, BASARABA, Randall J

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Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation by Redente, Elizabeth F., Higgins, David M., Dwyer-Nield, Lori D., Orme, Ian M., Gonzalez-Juarrero, Mercedes, Malkinson, Alvin M.

“…Alveolar macrophages undergo similar polarization to chemically and pathogen‐induced chronic lung inflammation, but the phenotype of bone marrow‐derived…”
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Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis by Palanisamy, Gopinath S, Kirk, Natalie M, Ackart, David F, Shanley, Crystal A, Orme, Ian M, Basaraba, Randall J

“…The development of granulomatous inflammation with caseous necrosis is an important but poorly understood manifestation of tuberculosis in humans and some…”
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The Hypervirulent Mycobacterium tuberculosis Strain HN878 Induces a Potent TH1 Response followed by Rapid Down-Regulation by Ordway, Diane, Henao-Tamayo, Marcela, Harton, Marisa, Palanisamy, Gopinath, Troudt, Jolynn, Shanley, Crystal, Basaraba, Randall J, Orme, Ian M

“…The HN878 strain of Mycobacterium tuberculosis is regarded as "hypervirulent" due to its rapid growth and reduced survival of infected mice when compared with…”
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The Efficacy of the BCG Vaccine against Newly Emerging Clinical Strains of Mycobacterium tuberculosis by Henao-Tamayo, Marcela, Shanley, Crystal A, Verma, Deepshikha, Zilavy, Andrew, Stapleton, Margaret C, Furney, Synthia K, Podell, Brendan, Orme, Ian M

“…To date, most new vaccines against Mycobacterium tuberculosis, including new recombinant versions of the current BCG vaccine, have usually been screened…”
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Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity to Mycobacterium tuberculosis by Orme, Ian M, Henao-Tamayo, Marcela I

“…The purpose of vaccination against tuberculosis and other diseases is to establish a heightened state of acquired specific resistance in which the memory…”
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Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis by Hinchey, Joseph, Lee, Sunhee, Jeon, Bo Y, Basaraba, Randall J, Venkataswamy, Manjunatha M, Chen, Bing, Chan, John, Braunstein, Miriam, Orme, Ian M, Derrick, Steven C, Morris, Sheldon L, Jacobs, Jr, William R, Porcelli, Steven A

“…The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of pathogenic mycobacteria. We show that inactivation of the…”
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Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease by Chan, Edward D, Bai, Xiyuan, Kartalija, Marinka, Orme, Ian M, Ordway, Diane J

“…Rapidly growing mycobacteria (RGM) are environmental organisms classified under the broader category of nontuberculous mycobacteria. The most common RGM to…”
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Comparative Studies Evaluating Mouse Models Used for Efficacy Testing of Experimental Drugs against Mycobacterium tuberculosis by DE GROOTE, Mary A, GILLILAND, Janet C, WELLS, Colby L, BROOKS, Elizabeth J, WOOLHISER, Lisa K, GRUPPO, Veronica, PELOQUIN, Charles A, ORME, Ian M, LENAERTS, Anne J

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Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models by LENAERTS, Anne J, GRUPPO, Veronica, MARIETTA, Karen S, JOHNSON, Christine M, DRISCOLL, Diane K, TOMPKINS, Nicholas M, ROSE, Jerry D, REYNOLDS, Robert C, ORME, Ian M

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Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys by Reed, Steven G, Coler, Rhea N, Dalemans, Wilifred, Tan, Esterlina V, DeLa Cruz, Eduardo C, Basaraba, Randall J, Orme, Ian M, Skeiky, Yasir A.W, Alderson, Mark R, Cowgill, Karen D, Prieels, Jean-Paul, Abalos, Rodolfo M, Dubois, Marie-Claude, Cohen, Joe, Mettens, Pascal, Lobet, Yves

“…The development of a vaccine for tuberculosis requires a combination of antigens and adjuvants capable of inducing appropriate and long-lasting T cell…”
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Phenotypic Definition of Effector and Memory T-Lymphocyte Subsets in Mice Chronically Infected with Mycobacterium tuberculosis by Henao-Tamayo, Marcela I, Ordway, Diane J, Irwin, Scott M, Shang, Shaobin, Shanley, Crystal, Orme, Ian M

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Uptake and accumulation of oxidized low-density lipoprotein during Mycobacterium tuberculosis infection in guinea pigs by Palanisamy, Gopinath S, Kirk, Natalie M, Ackart, David F, Obregón-Henao, Andrés, Shanley, Crystal A, Orme, Ian M, Basaraba, Randall J

“…The typical host response to infection of humans and some animals by M. tuberculosis is the accumulation of reactive oxygen species generating inflammatory…”
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Beijing Sublineages of Mycobacterium tuberculosis Differ in Pathogenicity in the Guinea Pig by Kato-Maeda, Midori, Shanley, Crystal A., Ackart, David, Jarlsberg, Leah G., Shang, Shaobin, Obregon-Henao, Andres, Harton, Marisabel, Basaraba, Randall J., Henao-Tamayo, Marcela, Barrozo, Joyce C., Rose, Jordan, Kawamura, L. Masae, Coscolla, Mireia, Fofanov, Viacheslav Y., Koshinsky, Heather, Gagneux, Sebastien, Hopewell, Philip C., Ordway, Diane J., Orme, Ian M.

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Role for Matrix Metalloproteinase 9 in Granuloma Formation during Pulmonary Mycobacterium tuberculosis Infection by Taylor, Jennifer L, Hattle, Jessica M, Dreitz, Steven A, Troudt, JoLynn M, Izzo, Linda S, Basaraba, Randall J, Orme, Ian M, Matrisian, Lynn M, Izzo, Angelo A

“…Recent studies have shown that matrix metalloproteinases (MMPs) are induced by Mycobacterium tuberculosis during pulmonary infection. Here, expression of MMP-9…”
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