Search Results - "Orlowski, Marek"

LAP: Liability Antibody Profiler by sequence & structural mapping of natural and therapeutic antibodies by Satława, Tadeusz, Tarkowski, Mateusz, Wróbel, Sonia, Dudzic, Paweł, Gawłowski, Tomasz, Klaus, Tomasz, Orłowski, Marek, Kostyn, Anna, Kumar, Sandeep, Buchanan, Andrew, Krawczyk, Konrad

“…Antibody-based therapeutics must not undergo chemical modifications that would impair their efficacy or hinder their developability. A commonly used technique…”
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Metal Ions Induce Liquid Condensate Formation by the F Domain of Aedes aegypti Ecdysteroid Receptor. New Perspectives of Nuclear Receptor Studies by Więch, Anna, Tarczewska, Aneta, Ożyhar, Andrzej, Orłowski, Marek

“…The superfamily of nuclear receptors (NRs), composed of ligand-activated transcription factors, is responsible for gene expression as a reaction to…”
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A Synergistic Formulation of Plant Extracts Decreases Postprandial Glucose and Insulin Peaks: Results from Two Randomized, Controlled, Cross-Over Studies Using Real-World Meals by Adamska-Patruno, Edyta, Billing-Marczak, Katarzyna, Orlowski, Marek, Gorska, Maria, Krotkiewski, Marcin, Kretowski, Adam

“…This study investigated the efficacy of a plant-derived dietary supplement with respect to decreasing postprandial glucose and insulin peaks after the intake…”
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Benchmarking antibody clustering methods using sequence, structural, and machine learning similarity measures for antibody discovery applications by Chomicz, Dawid, Kończak, Jarosław, Wróbel, Sonia, Satława, Tadeusz, Dudzic, Paweł, Janusz, Bartosz, Tarkowski, Mateusz, Deszyński, Piotr, Gawłowski, Tomasz, Kostyn, Anna, Orłowski, Marek, Klaus, Tomasz, Schulte, Lukas, Martin, Kyle, Comeau, Stephen R, Krawczyk, Konrad

“…Antibodies are proteins produced by our immune system that have been harnessed as biotherapeutics. The discovery of antibody-based therapeutics relies on…”
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Sequences that direct subcellular traffic of the Drosophila methoprene-tolerant protein (MET) are located predominantly in the PAS domains by Greb-Markiewicz, Beata, Orłowski, Marek, Dobrucki, Jerzy, Ożyhar, Andrzej

“…► We ask what elements affect subcellular traffic of methoprene-tolerant protein (MET). ► We identify mosaic of both nuclear localization signals and nuclear…”
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Multidomain sumoylation of the ecdysone receptor (EcR) from Drosophila melanogaster by Seliga, Justyna, Bielska, Katarzyna, Wieczorek, Elżbieta, Orłowski, Marek, Niedenthal, Rainer, Ożyhar, Andrzej

“…•The three known EcR isoforms (A, B1 and B2) are targets of sumoylation.•Both predictions from bioinformatic tools and experimental data indicate that there is…”
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The variety of complexes formed by EcR and Usp nuclear receptors in the nuclei of living cells by Dutko-Gwóźdź, Joanna, Gwóźdź, Tomasz, Orłowski, Marek, Greb-Markiewicz, Beata, Duś, Danuta, Dobrucki, Jurek, Ożyhar, Andrzej

“…The heterodimer of the ecdysone receptor (EcR) and ultraspiracle (Usp), members of the nuclear receptor superfamily, is considered to be functional receptor…”
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Nuclear immunophilin FKBP39 from Drosophila melanogaster drives spontaneous liquid-liquid phase separation by Tarczewska, Aneta, Wycisk, Krzysztof, Orłowski, Marek, Waligórska, Agnieszka, Dobrucki, Jurek, Drewniak-Świtalska, Magda, Berlicki, Łukasz, Ożyhar, Andrzej

“…The FKBP39 from Drosophila melanogaster is a multifunctional regulatory immunophilin. It contains two globular domains linked by a highly charged disordered…”
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Plasticity of the Ecdysone Receptor DNA Binding Domain by Orłowski, Marek, Szyszka, Monika, Kowalska, Agnieszka, Grad, Iwona, Zoglowek, Anna, Rymarczyk, Grzegorz, Dobryszycki, Piotr, Krowarsch, Daniel, Rastinejad, Fraydoon, Kochman, Marian, Ożyhar, Andrzej

“…Ecdysteroids coordinate molting and metamorphosis in insects via a heterodimer of two nuclear receptors, the ecdysone receptor (EcR) and the ultraspiracle…”
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Homodimerization propensity of the intrinsically disordered N-terminal domain of Ultraspiracle from Aedes aegypti by Pieprzyk, Joanna, Zbela, Agnieszka, Jakób, Michał, Ożyhar, Andrzej, Orłowski, Marek

“…The mosquito Aedes aegypti is the principal vector of dengue, one of the most devastating arthropod-borne viral infections in humans. The isoform specific A/B…”
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Copper(II)-Binding Induces a Unique Polyproline Type II Helical Structure within the Ion-Binding Segment in the Intrinsically Disordered F‑Domain of Ecdysteroid Receptor from Aedes aegypti by Rowińska-Żyrek, Magdalena, Wiȩch, Anna, Wa̧tły, Joanna, Wieczorek, Robert, Witkowska, Danuta, Ożyhar, Andrzej, Orłowski, Marek

“…Reproduction of the dominant vector of Zika and dengue diseases, Aedes aegypti mosquito, is controlled by an active heterodimer complex composed of the…”
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The intrinsically disordered C-terminal F domain of the ecdysteroid receptor from Aedes aegypti exhibits metal ion-binding ability by Więch, Anna, Rowińska-Żyrek, Magdalena, Wątły, Joanna, Czarnota, Aleksandra, Hołubowicz, Rafał, Szewczuk, Zbigniew, Ożyhar, Andrzej, Orłowski, Marek

“…[Display omitted] •The F domain of EcR from A. aegypti (AaFEcR) belongs to a family of intrinsically disordered proteins (IDPs).•AaFEcR possesses putative…”
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Molecular determinants of Drosophila immunophilin FKBP39 nuclear localization by Orłowski, Marek, Popławska, Katarzyna, Pieprzyk, Joanna, Szczygieł-Sommer, Aleksandra, Więch, Anna, Zarębski, Mirosław, Tarczewska, Aneta, Dobrucki, Jurek, Ożyhar, Andrzej

“…FK506-binding proteins (FKBPs) belong to a distinct class of immunophilins that interact with immunosuppressants. They use their peptidyl-prolyl isomerase…”
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Intrinsically disordered N-terminal domain of the Helicoverpa armigera Ultraspiracle stabilizes the dimeric form via a scorpion-like structure by Wycisk, Krzysztof, Tarczewska, Aneta, Kaus-Drobek, Magdalena, Dadlez, Michał, Hołubowicz, Rafał, Pietras, Zbigniew, Dziembowski, Andrzej, Taube, Michał, Kozak, Maciej, Orłowski, Marek, Ożyhar, Andrzej

“…•We investigated the influence of the disordered NTD on distant domains of HaUsp.•The NTD determines the pattern of the protein-DNA interaction of full-length…”
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Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetramer with partly disordered tentacle-like C-terminal segments by Kozłowska, Małgorzata, Tarczewska, Aneta, Jakób, Michał, Bystranowska, Dominika, Taube, Michał, Kozak, Maciej, Czarnocki-Cieciura, Mariusz, Dziembowski, Andrzej, Orłowski, Marek, Tkocz, Katarzyna, Ożyhar, Andrzej

“…Nucleoplasmins are a nuclear chaperone family defined by the presence of a highly conserved N-terminal core domain. X-ray crystallographic studies of isolated…”
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The molecular basis of conformational instability of the ecdysone receptor DNA binding domain studied by in silico and in vitro experiments by Szamborska-Gbur, Agnieszka, Rymarczyk, Grzegorz, Orłowski, Marek, Kuzynowski, Tomasz, Jakób, Michał, Dziedzic-Letka, Agnieszka, Górecki, Andrzej, Dobryszycki, Piotr, Ożyhar, Andrzej

“…The heterodimer of the ecdysone receptor (EcR) and ultraspiracle (Usp), members of the nuclear receptors superfamily, regulates gene expression associated with…”
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The composite nature of the interaction between nuclear receptors EcR and DHR38 by Zoglowek, Anna, Orłowski, Marek, Pakuła, Szymon, Dutko-Gwóźdź, Joanna, Pajdzik, Dorota, Gwóźdź, Tomasz, Rymarczyk, Grzegorz, Wieczorek, Elżbieta, Dobrucki, Jurek, Dobryszycki, Piotr, Ożyhar, Andrzej

“…Ecdysteroids coordinate essential biological processes in Drosophila through a complex of two nuclear receptors, the ecdysteroid receptor (EcR) and the…”
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Novel DNA-binding element within the C-terminal extension of the nuclear receptor DNA-binding domain by Jakób, Michał, Kołodziejczyk, Robert, Orłowski, Marek, Krzywda, Szymon, Kowalska, Agnieszka, Dutko-Gwóźdź, Joanna, Gwóźdź, Tomasz, Kochman, Marian, Jaskólski, Mariusz, Ożyhar, Andrzej

“…The heterodimer of the ecdysone receptor (EcR) and ultraspiracle (Usp), members of the nuclear receptors superfamily, is considered as the functional receptor…”
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EcR and Usp, components of the ecdysteroid nuclear receptor complex, exhibit differential distribution of molecular determinants directing subcellular trafficking by Gwóźdź, Tomasz, Dutko-Gwóźdź, Joanna, Nieva, Claudia, Betańska, Katarzyna, Orłowski, Marek, Kowalska, Agnieszka, Dobrucki, Jurek, Spindler-Barth, Margarethe, Spindler, Klaus-Dieter, Ożyhar, Andrzej

“…Ecdysteroids coordinate development, reproduction and other essential biological processes in insects and other arthropods through the receptor which is a…”
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Regulatory elements in the juvenile hormone binding protein gene from Galleria mellonella — Topography of binding sites for Usp and EcRDBD by Sok, Agnieszka J., Andruszewska, Grażyna, Niewiadomska-Cimicka, Anna, Grad, Iwona, Rymarczyk, Grzegorz, Pajdzik, Dorota, Orłowski, Marek, Schmidt, Marcin T., Grajek, Włodzimierz, Ożyhar, Andrzej, Kochman, Marian

“…The juvenile hormone binding protein (JHBP) plays a key role in the protection and transport of the hormone to target tissues. In this report the sequence of…”
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