Search Results - "Orlovskiy, Stepan"

Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition by Nath, Kavindra, Gupta, Pradeep K, Basappa, Johnvesly, Wang, Shengchun, Sen, Neil, Lobello, Cosimo, Tomar, Jyoti S, Shestov, Alexander A, Orlovskiy, Stepan, Arias-Mendoza, Fernando, Rauert-Wunderlich, Hilka, Nelson, David S, Glickson, Jerry D, Wasik, Mariusz A

“…Inhibition of kinases is the ever-expanding therapeutic approach to various types of cancer. Typically, assessment of the treatment response is accomplished by…”
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1H and 31P Magnetic Resonance Spectroscopic Metabolomic Imaging: Assessing Mitogen-Activated Protein Kinase Inhibition in Melanoma by Gupta, Pradeep Kumar, Orlovskiy, Stepan, Arias-Mendoza, Fernando, Nelson, David S., Nath, Kavindra

“…The MAPK signaling pathway with BRAF mutations has been shown to drive the pathogenesis of 40–60% of melanomas. Inhibitors of this pathway’s BRAF and MEK…”
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Effect of Differences in Metabolic Activity of Melanoma Models on Response to Lonidamine plus Doxorubicin by Nath, Kavindra, Roman, Jeffrey, Nelson, David S., Guo, Lili, Lee, Seung-Cheol, Orlovskiy, Stepan, Muriuki, Kevin, Heitjan, Daniel F., Pickup, Stephen, Leeper, Dennis B., Blair, Ian A., Putt, Mary E., Glickson, Jerry D.

“…Lonidamine (LND), a metabolic modulator, sensitizes DB-1 human melanoma to doxorubicin (DOX) chemotherapy by acidifying and de-energizing the tumor. This…”
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pH-dependent structural characteristics of lonidamine: H and C NMR study by Gupta, Pradeep Kumar, Orlovskiy, Stepan, Roman, Jeffrey, Pickup, Stephen, Nelson, David S, Glickson, Jerry D, Nath, Kavindra

“…Lonidamine (LND) is an anti-cancer drug with great potential as a metabolic modulator of chemotherapy, radiotherapy, hyperthermia, and photodynamic therapy in…”
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pH-dependent structural characteristics of lonidamine: 1 H and 13 C NMR study by Gupta, Pradeep Kumar, Orlovskiy, Stepan, Roman, Jeffrey, Pickup, Stephen, Nelson, David S, Glickson, Jerry D, Nath, Kavindra

“…Lonidamine (LND) is an anti-cancer drug with great potential as a metabolic modulator of chemotherapy, radiotherapy, hyperthermia, and photodynamic therapy in…”
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H and [sup.31]P Magnetic Resonance Spectroscopic Metabolomic Imaging: Assessing Mitogen-Activated Protein Kinase Inhibition in Melanoma by Gupta, Pradeep Kumar, Orlovskiy, Stepan, Arias-Mendoza, Fernando, Nelson, David S, Nath, Kavindra

“…The MAPK signaling pathway with BRAF mutations has been shown to drive the pathogenesis of 40–60% of melanomas. Inhibitors of this pathway’s BRAF and MEK…”
Get full text

1 H and 31 P Magnetic Resonance Spectroscopic Metabolomic Imaging: Assessing Mitogen-Activated Protein Kinase Inhibition in Melanoma by Gupta, Pradeep Kumar, Orlovskiy, Stepan, Arias-Mendoza, Fernando, Nelson, David S, Nath, Kavindra

“…The MAPK signaling pathway with mutations has been shown to drive the pathogenesis of 40-60% of melanomas. Inhibitors of this pathway's BRAF and MEK components…”
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Metabolic Imaging Biomarkers of Response to Signaling Inhibition Therapy in Melanoma by Gupta, Pradeep Kumar, Orlovskiy, Stepan, Arias-Mendoza, Fernando, Nelson, David S, Osborne, Aria, Pickup, Stephen, Glickson, Jerry D, Nath, Kavindra

“…Dabrafenib therapy for metastatic melanoma focuses on blocking growth-promoting signals produced by a hyperactive BRAF protein. We report the metabolic…”
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Lonidamine Induced Selective Acidification and De-Energization of Prostate Cancer Xenografts: Enhanced Tumor Response to Radiation Therapy by Orlovskiy, Stepan, Gupta, Pradeep Kumar, Roman, Jeffrey, Arias-Mendoza, Fernando, Nelson, David S, Koch, Cameron J, Narayan, Vivek, Putt, Mary E, Nath, Kavindra

“…Prostate cancer is a multi-focal disease that can be treated using surgery, radiation, androgen deprivation, and chemotherapy, depending on its presentation…”
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pH-dependent structural characteristics of lonidamine: 1H and 13C NMR study by Gupta, Pradeep Kumar, Orlovskiy, Stepan, Roman, Jeffrey, Pickup, Stephen, Nelson, David S, Glickson, Jerry D, Nath, Kavindra

“…Lonidamine (LND) is an anti-cancer drug with great potential as a metabolic modulator of chemotherapy, radiotherapy, hyperthermia, and photodynamic therapy in…”
Get full text