The family of human Na,K-ATPase genes ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase

The multigene family of human Na,K-ATPase is composed of 5 α-subunit genes, 3 of which were shown to encode the functionally active α1, α2 and α3 isoforms of the catalytic subunit. This report describes the isolation, mapping and partial sequencing of the fourth gene ( ATP1AL1) that was demonstrated...

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Bibliographic Details
Published in:	FEBS letters Vol. 278; no. 1; pp. 91 - 94
Main Authors:	Modyanov, N.N., Petrukhin, K.E., Sverdlov, V.E., Grishin, A.V., Orlova, M.Y., Kostina, M.B., Makarevich, O.I., Broude, N.E., Monastyrskaya, G.S., Sverdlov, E.D.
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 14-01-1991
Subjects:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Amino Acid Sequence Base Sequence Biological Transport Brain - enzymology Electrophoresis, Agar Gel Exons Gene family genes Human genome Humans Introns Ion transport ATPase Kidney - enzymology Molecular Sequence Data Multigene Family Na +,K +-ATPase Oligonucleotide Probes Polymerase Chain Reaction Sequence Homology, Nucleic Acid Sodium-Potassium-Exchanging ATPase - genetics Transcription, Genetic Gene family Human genome Na +,K +-ATPase Ion transport ATPase
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Summary:	The multigene family of human Na,K-ATPase is composed of 5 α-subunit genes, 3 of which were shown to encode the functionally active α1, α2 and α3 isoforms of the catalytic subunit. This report describes the isolation, mapping and partial sequencing of the fourth gene ( ATP1AL1) that was demonstrated here to be functionally active and expressed in human brain and kidney. Limited DNA sequencing of the ATP1AL1 exons allowed one to suggest that the gene probably encodes a new ion transport ATPase rather than an isoform of the Na,K-ATPase or the closely related H,K-ATPase.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(91)80091-G