Search Results - "Orleth, Annette"

Targeting Tumor-Associated Endothelial Cells: Anti-VEGFR2 Immunoliposomes Mediate Tumor Vessel Disruption and Inhibit Tumor Growth by WICKI, Andreas, ROCHLITZ, Christoph, ORLETH, Annette, RITSCHARD, Reto, ALBRECHT, Imke, HERRMANN, Richard, CHRISTOFORI, Gerhard, MAMOT, Christoph

“…Angiogenesis is a key process in tumor progression. By binding VEGF, VEGF receptor-2 (VEGFR2) is a main signaling transducer in tumor-associated angiogenesis…”
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MultiSCRIPT-Cycle 1-a pragmatic trial embedded within the Swiss Multiple Sclerosis Cohort (SMSC) on neurofilament light chain monitoring to inform personalized treatment decisions in multiple sclerosis: a study protocol for a randomized clinical trial by Janiaud, Perrine, Zecca, Chiara, Salmen, Anke, Benkert, Pascal, Schädelin, Sabine, Orleth, Annette, Demuth, Lilian, Maceski, Aleksandra Maleska, Granziera, Cristina, Oechtering, Johanna, Leppert, David, Derfuss, Tobias, Achtnichts, Lutz, Findling, Oliver, Roth, Patrick, Lalive, Patrice, Uginet, Marjolaine, Müller, Stefanie, Pot, Caroline, Hoepner, Robert, Disanto, Giulio, Gobbi, Claudio, Rooshenas, Leila, Schwenkglenks, Matthias, Lambiris, Mark J, Kappos, Ludwig, Kuhle, Jens, Yaldizli, Özgür, Hemkens, Lars G

“…Treatment decisions for persons with relapsing-remitting multiple sclerosis (RRMS) rely on clinical and radiological disease activity, the benefit-harm profile…”
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Generating evidence on a risk-based monitoring approach in the academic setting - lessons learned by von Niederhäusern, Belinda, Orleth, Annette, Schädelin, Sabine, Rawi, Nawal, Velkopolszky, Martin, Becherer, Claudia, Benkert, Pascal, Satalkar, Priya, Briel, Matthias, Pauli-Magnus, Christiane

“…In spite of efforts to employ risk-based strategies to increase monitoring efficiency in the academic setting, empirical evidence on their effectiveness…”
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Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair by Alcalay, Myriam, Meani, Natalia, Gelmetti, Vania, Fantozzi, Anna, Fagioli, Marta, Orleth, Annette, Riganelli, Daniela, Sebastiani, Carla, Cappelli, Enrico, Casciari, Cristina, Sciurpi, Maria Teresa, Mariano, Angela Rosa, Minardi, Simone Paolo, Luzi, Lucilla, Muller, Heiko, Di Fiore, Pier Paolo, Frosina, Guido, Pelicci, Pier Giuseppe

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Common themes in the pathogenesis of acute myeloid leukemia by Alcalay, M, Orleth, A, Sebastiani, C, Meani, N, Chiaradonna, F, Casciari, C, Sciurpi, M T, Gelmetti, V, Riganelli, D, Minucci, S, Fagioli, M, Pelicci, P G

“…The pathogenesis of acute myeloid leukemia is associated with the appearance of oncogenic fusion proteins generated as a consequence of specific chromosome…”
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Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis by Meier, Stephanie, Willemse, Eline A J, Schaedelin, Sabine, Oechtering, Johanna, Lorscheider, Johannes, Melie-Garcia, Lester, Cagol, Alessandro, Barakovic, Muhamed, Galbusera, Riccardo, Subramaniam, Suvitha, Barro, Christian, Abdelhak, Ahmed, Thebault, Simon, Achtnichts, Lutz, Lalive, Patrice, Müller, Stefanie, Pot, Caroline, Salmen, Anke, Disanto, Giulio, Zecca, Chiara, D'Souza, Marcus, Orleth, Annette, Khalil, Michael, Buchmann, Arabella, Du Pasquier, Renaud, Yaldizli, Özgür, Derfuss, Tobias, Berger, Klaus, Hermesdorf, Marco, Wiendl, Heinz, Piehl, Fredrik, Battaglini, Marco, Fischer, Urs, Kappos, Ludwig, Gobbi, Claudio, Granziera, Cristina, Bridel, Claire, Leppert, David, Maleska Maceski, Aleksandra, Benkert, Pascal, Kuhle, Jens

“…There is a lack of validated biomarkers for disability progression independent of relapse activity (PIRA) in multiple sclerosis (MS). To determine how serum…”
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Granulocyte Activation and Astrocyte Damage Markers in CSF Differentiate Acute NMOSD and MOGAD from MS (P9-14.004) by Leppert, David, Watanabe, Mitsuru, Schaedelin, Sabine, Piehl, Fredrik, Fink, Katharina, Furlan, Roberto, Gastaldi, Matteo, Benkert, Pascal, Maleska, Aleksandra, Willemse, Eline, Oechtering, Johanna, Orleth, Annette, Meier, Stephanie, Anthony, Daniel, Kuhle, Jens

“…Abstract only…”
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PAX5 Expression in Acute Leukemias by Tiacci, Enrico, Pileri, Stefano, Orleth, Annette, Pacini, Roberta, Tabarrini, Alessia, Frenguelli, Federica, Liso, Arcangelo, Diverio, Daniela, Lo-Coco, Francesco, Falini, Brunangelo

“…Abstract The transcription factor PAX5 plays a key role in the commitment of hematopoietic precursors to the B-cell lineage, but its expression in acute…”
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The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies by RUTHARDT, M, ORLETH, A, PELICCI, P. G, TOMASSONI, L, PUCCETTI, E, RIGANELLI, D, ALCALAY, M, MANNUCCI, R, NICOLETTI, I, GRIGNANI, F, FAGIOLI, M

“…Acute promyelocytic leukaemia is characterized by translocations that involve the retinoic acid receptor alpha (RAR alpha) locus on chromosome 17 and the PML…”
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Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells by Giuliani, Virginia, Bossi, Daniela, Cambiaghi, Valeria, Gobbi, Alberto, Monestiroli, Silvia, Pelicci, Pier Giuseppe, Ronzoni, Simona, Alcalay, Myriam, Viale, Andrea, Ronchini, Chiara, Minucci, Saverio, Orleth, Annette, De Franco, Francesca, Muradore, Ivan

“…Rare cells with the properties of stem cells are integral to the development and perpetuation of leukaemias. A defining characteristic of stem cells is their…”
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Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS by Oechtering, Johanna, Lincke, Therese, Schaedelin, Sabine, Décard, Bernhard F., Maceski, Aleksandra, Orleth, Annette, Meier, Stephanie, Willemse, Eline, Buchmann, Arabella, Khalil, Michael, Derfuss, Tobias, Benkert, Pascal, Heijnen, Ingmar, Regeniter, Axel, Müller, Stefanie, Achtnichts, Lutz, Lalive, Patrice, Salmen, Anke, Pot, Caroline, Gobbi, Claudio, Kappos, Ludwig, Granziera, Cristina, Leppert, David, Schlaeger, Regina, Lieb, Johanna M., Kuhle, Jens

“…Objective Intrathecal Immunoglobulin M synthesis (IgMIntrathecal Fraction (IF)+) and spinal MRI lesions are both strong independent predictors of higher…”
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Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis by Oechtering, Johanna, Schaedelin, Sabine, Benkert, Pascal, Müller, Stefanie, Achtnichts, Lutz, Vehoff, Jochen, Disanto, Giulio, Findling, Oliver, Fischer‐Barnicol, Bettina, Orleth, Annette, Chan, Andrew, Pot, Caroline, Barakovic, Muhamed, Rahmanzadeh, Reza, Galbusera, Riccardo, Heijnen, Ingmar, Lalive, Patrice H., Wuerfel, Jens, Subramaniam, Suvitha, Aeschbacher, Stefanie, Conen, David, Naegelin, Yvonne, Maceski, Aleksandra, Meier, Stephanie, Berger, Klaus, Wiendl, Heinz, Lincke, Therese, Lieb, Johanna, Yaldizli, Özgür, Sinnecker, Tim, Derfuss, Tobias, Regeniter, Axel, Zecca, Chiara, Gobbi, Claudio, Kappos, Ludwig, Granziera, Cristina, Leppert, David, Kuhle, Jens

“…Objective We aimed to determine in relapsing multiple sclerosis (MS) whether intrathecal synthesis of immunoglobulin (Ig) M and IgG is associated with outcomes…”
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Granulocyte activation markers in cerebrospinal fluid differentiate acute neuromyelitis spectrum disorder from multiple sclerosis by Leppert, David, Watanabe, Mitsuru, Schaedelin, Sabine, Piehl, Fredrik, Furlan, Roberto, Gastaldi, Matteo, Lambert, Jeremy, Evertsson, Björn, Fink, Katharina, Matsushita, Takuya, Masaki, Katsuhisa, Isobe, Noriko, Kira, Jun-ichi, Benkert, Pascal, Maceski, Aleksandra, Willemse, Eline, Oechtering, Johanna, Orleth, Annette, Meier, Stephanie, Kuhle, Jens

“…BackgroundGranulocyte invasion into the brain is a pathoanatomical feature differentiating neuromyelitis optica spectrum disorder (NMOSD) from multiple…”
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Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis by Abdelhak, Ahmed, Benkert, Pascal, Schaedelin, Sabine, Boscardin, W John, Cordano, Christian, Oechtering, Johanna, Ananth, Kirtana, Granziera, Cristina, Melie-Garcia, Lester, Montes, Shivany Condor, Beaudry-Richard, Alexandra, Achtnichts, Lutz, Oertel, Frederike C, Lalive, Patrice H, Leppert, David, Müller, Stefanie, Henry, Roland G, Pot, Caroline, Matthias, Amandine, Salmen, Anke, Oksenberg, Jorge R, Disanto, Giulio, Zecca, Chiara, D'Souza, Marcus, Du Pasquier, Renaud, Bridel, Claire, Gobbi, Claudio, Kappos, Ludwig, Hauser, Stephen L, Cree, Bruce A C, Kuhle, Jens, Green, Ari J

“…Mechanisms contributing to disability accumulation in multiple sclerosis (MS) are poorly understood. Blood neurofilament light chain (NfL) level, a marker of…”
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Simultaneous targeting of VEGF-receptors 2 and 3 with immunoliposomes enhances therapeutic efficacy by Orleth, Annette, Mamot, Christoph, Rochlitz, Christoph, Ritschard, Reto, Alitalo, Kari, Christofori, Gerhard, Wicki, Andreas

“…Background: Tumor progression depends on angiogenesis. Vascular endothelial growth factor (VEGF) receptors (VEGFRs) are the main signal transducers that…”
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Serum Glial Fibrillary Acidic Protein compared with Neurofilament Light Chain as Biomarker for Multiple Sclerosis Disease Progression (P5-3.016) by Meier, Stephanie, Benkert, Pascal, Maceski, Aleksandra Maleska, Schaedelin, Sabine, Oechtering, Johanna, Melie-Garcia, Lester, Cagol, Alessandro, Barakovic, Muhamed, Galbusera, Riccardo, Achtnichts, Lutz, Lalive, Patrice H., Bridel, Claire, Müller, Stefanie, Pot, Caroline, Salmen, Anke, Disanto, Giulio, Zecca, Chiara, Abdelhak, Ahmed, Barro, Christian, Thebault, Simon, D’Souza, Marcus, Derfuss, Tobias, Orleth, Annette, Khalil, Michael, Yaldizli, Özguer, Hermesdorf, Marco, Wiendl, Heinz, Piehl, Fredrik, Fischer, Urs, Kappos, Ludwig, Gobbi, Claudio, Granziera, Cristina, Leppert, David, Willemse, Eline A.J., Kuhle, Jens

“…Abstract only…”
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Complement Activation Is Associated With Disease Severity in Multiple Sclerosis by Oechtering, Johanna, Stein, Kerstin, Schaedelin, Sabine A, Maceski, Aleksandra M, Orleth, Annette, Meier, Stephanie, Willemse, Eline, Qureshi, Ferhan, Heijnen, Ingmar, Regeniter, Axel, Derfuss, Tobias, Benkert, Pascal, D'Souza, Marcus, Limberg, Marguerite, Fischer-Barnicol, Bettina, Achtnichts, Lutz, Mueller, Stefanie, Salmen, Anke, Lalive, Patrice H, Bridel, Claire, Pot, Caroline, Du Pasquier, Renaud A, Gobbi, Claudio, Wiendl, Heinz, Granziera, Cristina, Kappos, Ludwig, Trendelenburg, Marten, Leppert, David, Luenemann, Jan D, Kuhle, Jens

“…Histopathologic studies have identified immunoglobulin (Ig) deposition and complement activation as contributors of CNS tissue damage in multiple sclerosis…”
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Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair by Alcalay, Myriam, Meani, Natalia, Gelmetti, Vania, Fantozzi, Anna, Fagioli, Marta, Orleth, Annette, Riganelli, Daniela, Sebastiani, Carla, Cappelli, Enrico, Casciari, Cristina, Sciurpi, Maria Teresa, Mariano, Angela Rosa, Minardi, Simone Paolo, Luzi, Lucilla, Muller, Heiko, Di Fiore, Pier Paolo, Frosina, Guido, Pelicci, Pier Giuseppe

“…Acute myelogenous leukemias (AMLs) are genetically heterogeneous and characterized by chromosomal rearrangements that produce fusion proteins with aberrant…”
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Abstract 5714: Combination of glucagon-like-peptide-1 (GLP-1) receptor targeted therapy with anti-angiogenic compounds in a mouse model of neuroendocrine tumors by Wicki, Andreas, Wild, Damian, Orleth, Annette, Rochlitz, Christoph, Mamot, Christoph, Christofori, Gerhard

“…Abstract Neuroendocrine tumors are well vascularized and express specific cell surface markers, such as somatostatin receptors and glucagon-like peptide-1…”
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Abstract 3634: Selective targeting of tumor-associated angiogenic tip and stalk cells with immunoliposomes (ILs) directed against VEGFR-2 and VEGFR-3 expressing cells by Wicki, Andreas, Rochlitz, Christoph, Orleth, Annette, Ritschard, Reto, Alitalo, Kari, Herrmann, Richard, Christofori, Gerhard, Mamot, Christoph

“…Abstract Angiogenesis is a key process in tumor progression. Angiogenic sprouting involves specification of subpopulations of endothelial cells into tip cells…”
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