Search Results - "Orlanski, Shari"
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Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing
Published in Genome Biology (15-07-2022)“…The Oxford Nanopore (ONT) platform provides portable and rapid genome sequencing, and its ability to natively profile DNA methylation without complex sample…”
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Tissue-specific DNA demethylation is required for proper B-cell differentiation and function
Published in Proceedings of the National Academy of Sciences - PNAS (03-05-2016)“…There is ample evidence that somatic cell differentiation during development is accompanied by extensive DNA demethylation of specific sites that vary between…”
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Aberrant DNA methylation in ES cells
Published in PloS one (22-05-2014)“…Both mouse and human embryonic stem cells can be differentiated in vitro to produce a variety of somatic cell types. Using a new developmental tracing…”
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Bright/Arid3A Acts as a Barrier to Somatic Cell Reprogramming through Direct Regulation of Oct4, Sox2, and Nanog
Published in Stem cell reports (14-01-2014)“…We show here that singular loss of the Bright/Arid3A transcription factor leads to reprograming of mouse embryonic fibroblasts (MEFs) and enhancement of…”
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NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis
Published in Immunity (Cambridge, Mass.) (16-01-2018)“…Natural killer (NK) cells are innate lymphoid cells, and their presence within human tumors correlates with better prognosis. However, the mechanisms by which…”
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Using nucleosome levels, copy number alterations, and DNA methylation to profile disease state through liquid biopsy
Published in Journal of clinical oncology (01-06-2022)“…e15014 Background: Nucleosomes are the repeating unit of chromatin that contain important signals for proper genomic function and transcriptional activity…”
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NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis
Published in Immunity (Cambridge, Mass.) (20-02-2018)“…(Immunity 48, 107-119; January 16, 2018) In the version of this article originally published online on January 9, Figure 3 was printed twice, once correctly…”
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Sex of the cell dictates its response: differential gene expression and sensitivity to cell death inducing stress in male and female cells
Published in The FASEB journal (01-06-2009)“…Sexual dimorphisms are typically attributed to the hormonal differences arising once sex differentiation has occurred. However, in some sexually dimorphic…”
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Epigenetic mechanism of FMR1 inactivation in Fragile X syndrome
Published in The International journal of developmental biology (2017)“…Fragile X syndrome is the most frequent cause of inherited intellectual disability. The primary molecular defect in this disease is the expansion of a CGG…”
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Aberrant DNA Methylation in ES Cells: e96090
Published in PloS one (01-05-2014)“…Both mouse and human embryonic stem cells can be differentiated in vitro to produce a variety of somatic cell types. Using a new developmental tracing…”
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Journal Article