Search Results - "Orlando, Benjamin J."

ABCG2 transports anticancer drugs via a closed-to-open switch by Orlando, Benjamin J., Liao, Maofu

“…ABCG2 is an ABC transporter that extrudes a variety of compounds from cells, and presents an obstacle in treating chemotherapy-resistant cancers. Despite…”
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Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone by Orlando, Benjamin J., Malkowski, Michael G.

“…Cyclooxygenase-2 (COX-2) catalyzes the oxygenation of arachidonic acid (AA) and endocannabinoid substrates, placing the enzyme at a unique junction between the…”
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Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex by Fan, Minrui, Zhang, Jinru, Tsai, Chen-Wei, Orlando, Benjamin J., Rodriguez, Madison, Xu, Yan, Liao, Maofu, Tsai, Ming-Feng, Feng, Liang

“…Mitochondria take up Ca 2+ through the mitochondrial calcium uniporter complex to regulate energy production, cytosolic Ca 2+ signalling and cell death 1 , 2 …”
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Architecture of a complete Bce-type antimicrobial peptide resistance module by George, Natasha L., Orlando, Benjamin J.

“…Gram-positive bacteria synthesize and secrete antimicrobial peptides that target the essential process of peptidoglycan synthesis. These antimicrobial peptides…”
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Genome wide structural prediction of ABC transporter systems in Bacillus subtilis by Mahendran, Ashwin, Orlando, Benjamin J

“…ABC transporters are a diverse superfamily of membrane protein complexes that utilize the binding/hydrolysis of ATP to power substrate movement across…”
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X-ray and cryo-EM structures of the mitochondrial calcium uniporter by Fan, Chao, Fan, Minrui, Orlando, Benjamin J., Fastman, Nathan M., Zhang, Jinru, Xu, Yan, Chambers, Melissa G., Xu, Xiaofang, Perry, Kay, Liao, Maofu, Feng, Liang

“…Mitochondrial calcium uptake is critical for regulating ATP production, intracellular calcium signalling, and cell death. This uptake is mediated by a highly…”
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Large protein organelles form a new iron sequestration system with high storage capacity by Giessen, Tobias W, Orlando, Benjamin J, Verdegaal, Andrew A, Chambers, Melissa G, Gardener, Jules, Bell, David C, Birrane, Gabriel, Liao, Maofu, Silver, Pamela A

“…Iron storage proteins are essential for cellular iron homeostasis and redox balance. Ferritin proteins are the major storage units for bioavailable forms of…”
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Substrate engagement by the intramembrane metalloprotease SpoIVFB by Orlando, Melanie A., Pouillon, Hunter J. T., Mandal, Saikat, Kroos, Lee, Orlando, Benjamin J.

“…S2P intramembrane metalloproteases regulate diverse signaling pathways across all three domains of life. However, the mechanism by which S2P metalloproteases…”
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Structural basis of lipopolysaccharide extraction by the LptB2FGC complex by Li, Yanyan, Orlando, Benjamin J., Liao, Maofu

“…In Gram-negative bacteria, lipopolysaccharide is essential for outer membrane formation and antibiotic resistance. The seven lipopolysaccharide transport (Lpt)…”
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Structural basis of lipopolysaccharide extraction by the LptB 2 FGC complex by Li, Yanyan, Orlando, Benjamin J, Liao, Maofu

“…In Gram-negative bacteria, lipopolysaccharide is essential for outer membrane formation and antibiotic resistance. The seven lipopolysaccharide transport (Lpt)…”
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Perception and protection: The role of Bce-modules in antimicrobial peptide resistance by Orlando, Benjamin J.

“…Continual synthesis and remodeling of the peptidoglycan layer surrounding Gram-positive cells is essential for their survival. Diverse antimicrobial peptides…”
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Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry by Lucido, Michael J, Orlando, Benjamin J, Vecchio, Alex J, Malkowski, Michael G

“…Aspirin and other nonsteroidal anti-inflammatory drugs target the cyclooxygenase enzymes (COX-1 and COX-2) to block the formation of prostaglandins. Aspirin is…”
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The structure of ibuprofen bound to cyclooxygenase-2 by Orlando, Benjamin J., Lucido, Michael J., Malkowski, Michael G.

“…The cyclooxygenases (COX-1 and COX-2) catalyze the rate-limiting step in the biosynthesis of prostaglandins, and are the pharmacological targets of…”
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Guarding the walls: the multifaceted roles of Bce modules in cell envelope stress sensing and antimicrobial resistance by George, Natasha L, Bennett, Ellen C, Orlando, Benjamin J

“…Bacteria have developed diverse strategies for defending their cell envelopes from external threats. In Firmicutes, one widespread strategy is to use Bce…”
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Crystal structure of rofecoxib bound to human cyclooxygenase-2 by Orlando, Benjamin J., Malkowski, Michael G.

“…Rofecoxib (Vioxx) was one of the first selective cyclooxygenase‐2 (COX‐2) inhibitors (coxibs) to be approved for use in humans. Within five years after its…”
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Conformational snapshots of the bacitracin sensing and resistance transporter BceAB by George, Natasha L, Schilmiller, Anthony L, Orlando, Benjamin J

“…SignificanceMany gram-positive organisms have evolved an elegant solution to sense and resist antimicrobial peptides that inhibit cell-wall synthesis. These…”
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High-resolution views of lipopolysaccharide translocation driven by ABC transporters MsbA and LptB2FGC by Thélot, François, Orlando, Benjamin J, Li, Yanyan, Liao, Maofu

“…Gram-negative bacteria possess a dual-membrane envelope, which provides defense against environmental assault, as well as formidable resistance against…”
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Structure and mechanism of the cation–chloride cotransporter NKCC1 by Chew, Thomas A., Orlando, Benjamin J., Zhang, Jinru, Latorraca, Naomi R., Wang, Amy, Hollingsworth, Scott A., Chen, Dong-Hua, Dror, Ron O., Liao, Maofu, Feng, Liang

“…Cation–chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium and/or sodium across the membrane. They have critical roles…”
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Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes by Orlando, Benjamin J., Dominik, Pawel K., Roy, Sourav, Ogbu, Chinemerem P., Erramilli, Satchal K., Kossiakoff, Anthony A., Vecchio, Alex J.

“…Strains of Clostridium perfringens produce a two-domain enterotoxin (CpE) that afflicts humans and domesticated animals, causing prevalent gastrointestinal…”
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Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit by Dong, Liang, Yuan, Chong, Orlando, Benjamin J., Malkowski, Michael G., Smith, William L.

“…Prostaglandin endoperoxide H synthase-2 (PGHS-2), also called cyclooxygenase-2 (COX-2), converts arachidonic acid to PGH2. PGHS-2 is a conformational…”
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