Search Results - "Orlandini, E"
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Polymer model with Epigenetic Recoloring Reveals a Pathway for the de novo Establishment and 3D Organization of Chromatin Domains
Published in Physical review. X (01-12-2016)“…One of the most important problems in development is how epigenetic domains can first be established, and then maintained, within cells. To address this…”
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Physical principles of retroviral integration in the human genome
Published in Nature communications (04-02-2019)“…Certain retroviruses, including HIV, insert their DNA in a non-random fraction of the host genome via poorly understood selection mechanisms. Here, we develop…”
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3
Circular Polycatenanes: Supramolecular Structures with Topologically Tunable Properties
Published in Physical review letters (23-11-2022)“…Polycatenanes, macrochains of topologically interlocked rings with unique physical properties have recently gained considerable interest in supramolecular…”
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Statistical topology of closed curves: Some applications in polymer physics
Published in Reviews of modern physics (23-04-2007)Get full text
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Motility-induced phase separation in an active dumbbell fluid
Published in Europhysics letters (01-12-2014)“…We study a suspension of active dumbbells of variable density, as a minimal example of an active polar fluid. As in a fluid of spherical swimmers, we find that…”
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Cholesteric Shells: Two-Dimensional Blue Fog and Finite Quasicrystals
Published in Physical review letters (14-01-2022)“…We study the phase behavior of a quasi-two-dimensional cholesteric liquid crystal shell. We characterize the topological phases arising close to the…”
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Epigenetic Transitions and Knotted Solitons in Stretched Chromatin
Published in Scientific reports (07-11-2017)“…The spreading and regulation of epigenetic marks on chromosomes is crucial to establish and maintain cellular identity. Nonetheless, the dynamic mechanism…”
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8
Biopolymer organization upon confinement
Published in Journal of physics. Condensed matter (21-07-2010)“…Biopolymers in vivo are typically subject to spatial restraints, either as a result of molecular crowding in the cellular medium or of direct spatial…”
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Lamellar ordering, droplet formation and phase inversion in exotic active emulsions
Published in Scientific reports (26-02-2019)“…We study numerically the behaviour of a two-dimensional mixture of a passive isotropic fluid and an active polar gel, in the presence of a surfactant favouring…”
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Investigating site-selection mechanisms of retroviral integration in supercoiled DNA braids
Published in Journal of the Royal Society interface (25-08-2021)“…We theoretically study the integration of short viral DNA in a DNA braid made up by two entwined double-stranded DNA molecules. We show that the statistics of…”
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Shearing active gels close to the isotropic-nematic transition
Published in Physical review letters (08-08-2008)“…We study numerically the rheological properties of a slab of active gel close to the isotropic-nematic transition. The flow behavior shows a strong dependence…”
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12
Driven Translocation of Linked Ring Polymers through a Pore
Published in Macromolecules (12-12-2017)“…We have carried out a systematic computational investigation of the driven translocation dynamics of mutually entangled pairs of flexible polymers. Once closed…”
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13
Linking of Ring Polymers in Slit-Like Confinement
Published in Macromolecules (28-02-2017)“…Stochastic simulations are used to study the linking properties of solutions of circular polymers in slit confinement. Specifically, we consider dispersions of…”
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Hydrodynamics and rheology of active liquid crystals: a numerical investigation
Published in Physical review letters (16-03-2007)“…We report numerical studies of the hydrodynamics and rheology of an active liquid crystal. We confirm the existence of a transition between a passive and an…”
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TTR fibril formation inhibitors: is there a SAR?
Published in Current medicinal chemistry (2012)“…Transthyretin is a homotetrameric protein that carries thyroxine and retinol binding protein in plasma and is associated with a variety of amyloid diseases…”
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Bistable defect structures in blue phase devices
Published in Physical review letters (01-12-2011)“…Blue phases are liquid crystals made up by networks of defects, or disclination lines. While existing phase diagrams show a striking variety of competing…”
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17
Simulations of Knotting in Confined Circular DNA
Published in Biophysical journal (15-10-2008)“…The packing of DNA inside bacteriophages arguably yields the simplest example of genome organization in living organisms. As an assay of packing geometry, the…”
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Entropic elasticity and dynamics of the bacterial chromosome: A simulation study
Published in The Journal of chemical physics (28-07-2017)“…We study the compression and extension dynamics of a DNA-like polymer interacting with non-DNA binding and DNA-binding proteins, by means of computer…”
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Electric field controlled columnar and planar patterning of cholesteric colloids
Published in Physical review letters (01-05-2015)“…We study how dispersions of colloidal particles in a cholesteric liquid crystal behave under a time-dependent electric field. By controlling the amplitude and…”
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Facilitated diffusion on confined DNA
Published in Physical review. E, Statistical, nonlinear, and soft matter physics (01-02-2012)“…In living cells, proteins combine three-dimensional bulk diffusion and one-dimensional sliding along the DNA to reach a target faster. This process is known as…”
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