Search Results - "Orlandin, Andrea"
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Carbodiimide-Mediated Beckmann Rearrangement of Oxyma-B as a Side Reaction in Peptide Synthesis
Published in Molecules (Basel, Switzerland) (30-06-2022)“…The suppression of side reactions is one of the most important objectives in peptide synthesis, where highly reactive compounds are involved. Recently, the…”
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Reversible Chirality Control in Peptide-Functionalized Gold Nanoparticles
Published in ACS nano (26-11-2013)“…We report the induction of chiroptical properties in 2 nm diameter gold nanoparticles passivated with short peptides characterized by the Aib-l-Ala repetition…”
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High–throughput enantioseparation of Nα–fluorenylmethoxycarbonyl proteinogenic amino acids through fast chiral chromatography on zwitterionic-teicoplanin stationary phases
Published in Journal of Chromatography A (02-08-2020)“…•31 racemates of Nα–FMOC proteinogenic amino acids were successfully resolved•Comparison between zwitterionic teicoplanin-based CSPs and commercial…”
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Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 2
Published in Organic process research & development (21-02-2020)“…The hydrolysis and rearrangement of the dihydroorotic (Hor) residue in the presence of bases, leading to the formation of the hydantoin (Hyd) impurity,…”
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Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 1
Published in Organic process research & development (20-12-2019)“…The highly potent, long-acting, gonadotropin-releasing hormone antagonist Degarelix is known to be very efficient for prostate cancer treatment. The synthesis…”
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Copper(II) Lysinate and Pseudoproline Assistance in the Convergent Synthesis of the GLP‑1 Receptor Agonists Liraglutide and Semaglutide
Published in Organic process research & development (16-07-2021)“…A growing interest in peptides as active pharmaceutical ingredients (APIs) requires the development of efficient strategies for their preparation. This is…”
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Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography
Published in RSC advances (27-03-2020)“…The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of…”
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Cotton functionalized with peptides: characterization and synthetic methods
Published in Journal of peptide science (01-07-2014)“…Three approaches for the chemical ligation of peptides to cotton fibers are described and compared. This investigation was encouraged by the need to create…”
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Innovative chemical synthesis and conformational hints on the lipopeptide liraglutide
Published in Journal of peptide science (01-07-2016)“…Liraglutide is a new generation lipopeptide drug used for the treatment of type II diabetes. In this work, we describe new approaches for its preparation fully…”
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