Search Results - "Orkwis, Jacob A."

Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases by Xu, Zhenyuan, Orkwis, Jacob A., Harris, Greg M.

“…Schwann cells (SCs) are a highly plastic cell type capable of undergoing phenotypic changes following injury or disease. SCs are able to upregulate genes…”
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The impact of physical, biochemical, and electrical signaling on Schwann cell plasticity by Smith, Corinne S., Orkwis, Jacob A., Bryan, Andrew E., Xu, Zhenyuan, Harris, Greg M.

“…Peripheral nervous system (PNS) injuries are an ongoing health care concern. While autografts and allografts are regarded as the current clinical standard for…”
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Micropatterning Decellularized ECM as a Bioactive Surface to Guide Cell Alignment, Proliferation, and Migration by Cady, Emily, Orkwis, Jacob A., Weaver, Rachel, Conlin, Lia, Madigan, Nicolas N., Harris, Greg M.

“…Bioactive surfaces and materials have displayed great potential in a variety of tissue engineering applications but often struggle to completely emulate…”
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Extracellular matrix cues modulate Schwann cell morphology, proliferation, and protein expression by Xu, Zhenyuan, Orkwis, Jacob A., DeVine, Braden M., Harris, Greg M.

“…Peripheral nerve injuries require a complex set of signals from cells, macrophages, and the extracellular matrix (ECM) to induce regeneration across injury…”
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Development of a Piezoelectric PVDF‐TrFE Fibrous Scaffold to Guide Cell Adhesion, Proliferation, and Alignment by Orkwis, Jacob A., Wolf, Ann K., Shahid, Syed M., Smith, Corinne, Esfandiari, Leyla, Harris, Greg M.

“…Severe peripheral nervous system injuries currently hold limited therapeutic solutions. Existing clinical techniques such as autografts, allografts, and newer…”
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