Search Results - "Orita, Takuya"

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders by Noji, Satoru, Hara, Yoshinori, Miura, Tomoya, Yamanaka, Hiroshi, Maeda, Katsuya, Hori, Akimi, Yamamoto, Hiroshi, Obika, Shingo, Inoue, Masafumi, Hase, Yasunori, Orita, Takuya, Doi, Satoki, Adachi, Tsuyoshi, Tanimoto, Atsuo, Oki, Chika, Kimoto, Yukari, Ogawa, Yoshihiro, Negoro, Tamotsu, Hashimoto, Hiromasa, Shiozaki, Makoto

“…Dermatologic disorders such as atopic dermatitis arise from genetic and environmental causes and are complex and multifactorial in nature. Among possible risk…”
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Molecular Cloning, Genomic Structure, and Expression Analysis of MUC20, a Novel Mucin Protein, Up-regulated in Injured Kidney by Higuchi, Toshio, Orita, Takuya, Nakanishi, Setsuko, Katsuya, Ken, Watanabe, Hirotaka, Yamasaki, Yoshiki, Waga, Iwao, Nanayama, Toyomichi, Yamamoto, Yoshihisa, Munger, William, Sun, Hong-Wei, Falk, Ronald J., Jennette, J.Charles, Alcorta, David A., Li, Huiping, Yamamoto, Tadashi, Saito, Yutaka, Nakamura, Motonao

“…Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis in the world. Here, we identify a cDNA encoding a novel mucin protein, shown…”
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MUC20 Suppresses the Hepatocyte Growth Factor-Induced Grb2-Ras Pathway by Binding to a Multifunctional Docking Site of Met by Higuchi, Toshio, Orita, Takuya, Katsuya, Ken, Yamasaki, Yoshiki, Akiyama, Kiyotaka, Li, Huiping, Yamamoto, Tadashi, Saito, Yutaka, Nakamura, Motonao

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety by Adachi, Kaoru, Manabe, Tomoyuki, Yamasaki, Takayuki, Suma, Akira, Orita, Takuya, Furuzono, Tomoko, Adachi, Tsuyoshi, Ohata, Yoshitsugu, Akiyama, Yoshiyuki, Miyazaki, Susumu

“…[Display omitted] We report herein the design and discovery of novel allosteric HIV-1 integrase inhibitors. Our design concept utilized the spirocyclic moiety…”
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Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase by Inoue, Masafumi, Nagamori, Hironobu, Morita, Toru, Kobayashi, Satoru, Suzawa, Koichi, Kitao, Yuki, Saito, Tomoyuki, Kawahara, Iichiro, Orita, Takuya, Akai, Shota, Adachi, Tsuyoshi, Motomura, Takahisa

“…[Display omitted] Activation of pyruvate dehydrogenase (PDH) by inhibition of pyruvate dehydrogenase kinase (PDHK) has the potential for the treatment of…”
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Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques by Asano, Wataru, Yamanaka, Kenji, Ohara, Yasunori, Uhara, Toru, Doi, Satoki, Orita, Takuya, Iwanaga, Tomoko, Adachi, Tsuyoshi, Fujioka, Shingo, Akaki, Tatsuo, Ikegashira, Kazutaka, Hantani, Yoshiji

“…Tyrosine phosphorylation is an essential post-translational modification that regulates various biological events and is implicated in many diseases including…”
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Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases by Akaki, Tatsuo, Bessho, Yuki, Ito, Takashi, Fujioka, Shingo, Ubukata, Minoru, Mori, Genki, Yamanaka, Kenji, Orita, Takuya, Doi, Satoki, Iwanaga, Tomoko, Ikegashira, Kazutaka, Hantani, Yoshiji, Nakanishi, Isao, Adachi, Tsuyoshi

“…[Display omitted] A fragment-based lead discovery approach was applied to Pyruvate Dehydrogenase Kinases (PDHKs) to discover inhibitors against the ATP binding…”
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Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors by Bessho, Yuki, Akaki, Tatsuo, Hara, Yoshinori, Yamakawa, Maki, Obika, Shingo, Mori, Genki, Ubukata, Minoru, Yasue, Katsutaka, Nakane, Yoshitomi, Terasako, Yasuo, Orita, Takuya, Doi, Satoki, Iwanaga, Tomoko, Fujishima, Ayumi, Adachi, Tsuyoshi, Ueno, Hiroshi, Motomura, Takahisa

“…[Display omitted] Pyruvate dehydrogenase kinases (PDHKs) are fascinating drug targets for numerous diseases, including diabetes and cancers. In this report, we…”
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Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide by Ohba, Yusuke, Adachi, Kaoru, Furukawa, Takayuki, Nishimaru, Tatsuya, Sakurai, Kentaro, Masuo, Ritsuki, Inami, Tasuku, Orita, Takuya, Akai, Shota, Adachi, Tsuyoshi, Usui, Kenji, Hamada, Yuji, Mori, Mutsuki, Kurimoto, Takafumi, Wakashima, Takeshi, Akiyama, Yoshiyuki, Miyazaki, Susumu, Noji, Satoru

“…The NLRP3 inflammasome plays an important role in the defense mechanism of the innate immune system and has recently attracted much attention as a drug target…”
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Production of chicken ovalbumin in Escherichia coli by Takahashi, Nobuyuki, Orita, Takuya, Hirose, Masaaki

“…For better understanding of the structure-function relationship in serine proteinase inhibitors, a protein engineering approach for converting non-inhibitory…”
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Role of the Intrachain Disulfide Bond of Ovalbumin during Conversion into S-Ovalbumin by Takahashi, Nobuyuki, Tatsumi, Eizo, Orita, Takuya, Hirose, Masaaki

“…Disulfide-reduced and carboxymethylated ovalbumin was treated at pH 9.9 and 55°C for 24 h as a specific condition for preparation of S-ovalbumin. The stability…”
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Identification by differential display of eight known genes induced during in vivo intimal hyperplasia by Itoh, M, Tsukada, S, Orita, T, Nishiu, J, Tomoike, H, Nakamura, Y, Tanaka, T

“…To achieve a better understanding of the mechanism of intimal thickening, we used a rabbit model in which aorta was denuded mechanically by a balloon catheter…”
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