Search Results - "Oriol, Roger"

Optimization of liposomal topotecan for use in treating neuroblastoma by Chernov, Lina, Deyell, Rebecca J., Anantha, Malathi, Dos Santos, Nancy, Gilabert‐Oriol, Roger, Bally, Marcel B.

“…The purpose of this work was to develop an optimized liposomal formulation of topotecan for use in the treatment of patients with neuroblastoma. Drug exposure…”
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Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers by Fuchs, Hendrik, Weng, Alexander, Gilabert-Oriol, Roger

“…The toxic moiety of almost all protein-based targeted toxins must enter the cytosol of the target cell to mediate its fatal effect. Although more than 500…”
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Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy by Gilabert-Oriol, Roger, Weng, Alexander, Mallinckrodt, Benedicta von, Melzig, Matthias F, Fuchs, Hendrik, Thakur, Mayank

“…The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant origin, which have N-glycosidase enzymatic activity leading to a…”
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Liposomal Formulations to Modulate the Tumour Microenvironment and Antitumour Immune Response by Gilabert-Oriol, Roger, Ryan, Gemma M, Leung, Ada W Y, Firmino, Natalie S, Bennewith, Kevin L, Bally, Marcel B

“…Tumours are complex systems of genetically diverse malignant cells that proliferate in the presence of a heterogeneous microenvironment consisting of host…”
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Saponins modulate the intracellular trafficking of protein toxins by Weng, Alexander, Thakur, Mayank, von Mallinckrodt, Benedicta, Beceren-Braun, Figen, Gilabert-Oriol, Roger, Wiesner, Burkard, Eichhorst, Jenny, Böttger, Stefan, Melzig, Matthias F., Fuchs, Hendrik

“…Type I ribosome inactivating proteins such as saporin from the plant Saponaria officinalis L. are widely used as toxin moieties of targeted anti-tumor toxins…”
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Real-time analysis of membrane permeabilizing effects of oleanane saponins by Gilabert-Oriol, Roger, Mergel, Katharina, Thakur, Mayank, von Mallinckrodt, Benedicta, Melzig, Matthias F, Fuchs, Hendrik, Weng, Alexander

“…Saponins are a group of plant and marine derived glycosides with numerous biological functions. Two important characteristics of certain plant saponins are…”
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Saponins from Saponaria officinalis L. Augment the Efficacy of a Rituximab-Immunotoxin by Gilabert-Oriol, Roger, Thakur, Mayank, Haussmann, Katy, Niesler, Nicole, Bhargava, Cheenu, Görick, Cornelia, Fuchs, Hendrik, Weng, Alexander

“…Triterpenoidal saponins are synthesized in the roots of L. The same plant is also a source for the toxin Saporin, which is a ribosome-inactivating protein…”
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Groundwater Treatment using a Solid Polymer Electrolyte Cell with Mesh Electrodes by Oriol, Roger, Clematis, Davide, Brillas, Enric, Cortina, José L., Panizza, Marco, Sirés, Ignasi

“…This article reports the high performance of a solid polymer electrolyte cell, equipped with a Nafion® N117 membrane packed between a Nb/boron‐doped diamond…”
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Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: An evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice by Thakur, Mayank, Mergel, Katharina, Weng, Alexander, von Mallinckrodt, Benedicta, Gilabert-Oriol, Roger, Dürkop, Horst, Melzig, Matthias F., Fuchs, Hendrik

“…Targeted toxin-based therapeutics are hindered by poor intracellular uptake, limited stability and non-specific immune stimulation. To address these problems,…”
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A novel NH2-MIL-88B(Fe)-modified ceramic membrane for the integration of electro-Fenton and filtration processes: A case study on naproxen degradation by Ye, Zhihong, Oriol, Roger, Yang, Chao, Sirés, Ignasi, Li, Xiao-Yan

“…[Display omitted] •Novel NH2-MIL-88B(Fe)-decorated ceramic membrane for combined filtration-EF at mild pH.•Almost total degradation of naproxen in Na2SO4 after…”
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Analysis of the cumulative changes in Graves’ disease thyroid glands points to IFN signature, plasmacytoid DCs and alternatively activated macrophages as chronicity determining factors by Ruiz-Riol, Marta, Armengol Barnils, Maria del Pilar, Colobran Oriol, Roger, Sánchez Pla, Alex, Borràs Serres, Francesc-E, Lucas-Martin, Anna, Martínez Cáceres, Eva María, Pujol-Borrell, Ricardo

“…Abstract Graves’ disease (GD) is a chronic autoimmune process in the thyroid gland and involves IFN and IFN driven immune activation. Assuming the thyroid…”
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Reporter assay for endo/lysosomal escape of toxin-based therapeutics by Gilabert-Oriol, Roger, Thakur, Mayank, von Mallinckrodt, Benedicta, Bhargava, Cheenu, Wiesner, Burkhard, Eichhorst, Jenny, Melzig, Matthias F, Fuchs, Hendrik, Weng, Alexander

“…Protein-based therapeutics with cytosolic targets are capable of exhibiting their therapeutic effect once they have escaped from the endosomes or lysosomes. In…”
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A hybrid photoelectrocatalytic/photoelectro-Fenton treatment of Indigo Carmine in acidic aqueous solution using TiO2 nanotube arrays as photoanode by Oriol, Roger, Sirés, Ignasi, Brillas, Enric, De Andrade, Adalgisa Rodrigues

“…This article reports the synthesis of TiO2 nanotube arrays (TiO2 NTs), grown by Ti anodization, and their use as photoanode in a hybrid photelectrocatalytic…”
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Modeling the electrocatalytic nitrate removal in a rotating cylinder electrode reactor by Oriol, Roger, Nava, José L., Brillas, Enric, Cornejo, Oscar M., Sirés, Ignasi

“…[Display omitted] •Computational fluid dynamics used for the first time to model NO3− electroreduction.•Experimental NO3− removal at different U and [NO3−] in…”
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Recent Treatment Advances and the Role of Nanotechnology, Combination Products, and Immunotherapy in Changing the Therapeutic Landscape of Acute Myeloid Leukemia by Chen, Kent T. J., Gilabert-Oriol, Roger, Bally, Marcel B., Leung, Ada W. Y.

“…Acute myeloid leukemia (AML) is the most common acute leukemia that is becoming more prevalent particularly in the older (65 years of age or older) population…”
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Paired electrochemical removal of nitrate and terbuthylazine pesticide from groundwater using mesh electrodes by Oriol, Roger, Brillas, Enric, Cabot, Pere L., Cortina, José L., Sirés, Ignasi

“…•Successful paired electro-oxidation/electrodenitrification of groundwater with Fe cathodes.•Pseudo-first-order kinetics for NO3− and terbuthylazine (TBZE)…”
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Paired electro-oxidation of insecticide imidacloprid and electrodenitrification in simulated and real water matrices by Oriol, Roger, Bernícola, María del Pilar, Brillas, Enric, Cabot, Pere L., Sirés, Ignasi

“…Groundwater is one of the main freshwater resources on the Earth, but its contamination by NO3− and pesticides jeopardizes its suitability for consumption. In…”
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Diffusion-charge transfer characterization of a rotating cylinder electrode reactor used for the complete electrocatalytic removal of nitrate from water by Oriol, Roger, Nava, José L., Brillas, Enric, Sirés, Ignasi

“…Groundwater nitrate contamination is an emerging threat in stressed regions under intensive farming although, lately, efforts to valorize such residues are…”
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Polyendocrine autoimmune syndromes reveal mechanisms of tolerance and autoimmunity by Pujol-Borrell, Ricardo, Colobran Oriol, Roger

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A simple passive equilibration method for loading carboplatin into pre-formed liposomes incubated with ethanol as a temperature dependent permeability enhancer by Wehbe, Moe, Malhotra, Armaan, Anantha, Malathi, Roosendaal, Jeroen, Leung, Ada W.Y., Plackett, David, Edwards, Katarina, Gilabert-Oriol, Roger, Bally, Marcel B.

“…A passive equilibration method which relies on addition of candidate drugs to pre-formed liposomes is described as an alternative method for preparing liposome…”
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