Search Results - "Orimo, Akira"

Phenotypic heterogeneity, stability and plasticity in tumor‐promoting carcinoma‐associated fibroblasts by Mezawa, Yoshihiro, Orimo, Akira

“…Reciprocal interactions between cancer cells and stromal cells in the tumor microenvironment (TME) are essential for full‐blown tumor development…”
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The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas by Mezawa, Yoshihiro, Orimo, Akira

“…Carcinoma-associated fibroblasts (CAFs) constitute a substantial proportion of the non-neoplastic mesenchymal cell compartment in various human tumors. These…”
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Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies by Yoshida, Go J, Azuma, Arata, Miura, Yukiko, Orimo, Akira

“…Neoplastic epithelial cells coexist in carcinomas with various non-neoplastic stromal cells, together creating the tumor microenvironment. There is a growing…”
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Stromal Fibroblasts in Cancer: A Novel Tumor-Promoting Cell Type by Orimo, Akira, Weinberg, Robert A.

“…Tumors are highly complex tissues composed of neoplastic cells and, in the case of carcinomas, stromal cell compartments containing a variety of mesenchymal…”
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Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts by Kojima, Yasushi, Acar, Ahmet, Eaton, Elinor Ng, Mellody, Kieran T, Scheel, Christina, Ben-Porath, Ittai, Onder, Tamer T, Wang, Zhigang C, Richardson, Andrea L, Weinberg, Robert A, Orimo, Akira

“…Much interest is currently focused on the emerging role of tumor-stroma interactions essential for supporting tumor progression. Carcinoma-associated…”
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Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state by Mizukoshi, Kosuke, Okazawa, Yu, Haeno, Hiroshi, Koyama, Yu, Sulidan, Kaidiliayi, Komiyama, Hiromitsu, Saeki, Harumi, Ohtsuji, Naomi, Ito, Yasuhiko, Kojima, Yutaka, Goto, Michitoshi, Habu, Sonoko, Hino, Okio, Sakamoto, Kazuhiro, Orimo, Akira

“…Emerging evidence supports the theory that tumor cell clusters efficiently metastasize to distant organs. However, the roles of epithelial‐to‐mesenchymal…”
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Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling by Roswall, Pernilla, Bocci, Matteo, Bartoschek, Michael, Li, Hong, Kristiansen, Glen, Jansson, Sara, Lehn, Sophie, Sjölund, Jonas, Reid, Steven, Larsson, Christer, Eriksson, Pontus, Anderberg, Charlotte, Cortez, Eliane, Saal, Lao H, Orsmark-Pietras, Christina, Cordero, Eugenia, Haller, Bengt Kristian, Häkkinen, Jari, Burvenich, Ingrid J G, Lim, Elgene, Orimo, Akira, Höglund, Mattias, Rydén, Lisa, Moch, Holger, Scott, Andrew M, Eriksson, Ulf, Pietras, Kristian

“…Paracrine signaling networks in the breast cancer microenvironment uncover determinants of hormone receptor status and offer opportunities for therapeutic…”
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Carcinoma-associated fibroblasts are a promising therapeutic target by Togo, Shinsaku, Polanska, Urszula M, Horimoto, Yoshiya, Orimo, Akira

“…Human carcinomas frequently exhibit significant stromal reactions such as the so-called "desmoplastic stroma" or "reactive stroma", which is characterised by…”
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Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion by Orimo, Akira, Gupta, Piyush B., Sgroi, Dennis C., Arenzana-Seisdedos, Fernando, Delaunay, Thierry, Naeem, Rizwan, Carey, Vincent J., Richardson, Andrea L., Weinberg, Robert A.

“…Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the functional contributions of these cells to tumorigenesis are…”
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Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition by Gorji-Bahri, Gilar, Krishna, B Madhu, Hagerling, Catharina, Orimo, Akira, Jirström, Karin, Papadakos, Konstantinos S, Blom, Anna M

“…Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its overexpression is…”
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Mesenchymal Characteristics and Predictive Biomarkers on Circulating Tumor Cells for Therapeutic Strategy by Okabe, Takahiro, Togo, Shinsaku, Fujimoto, Yuichi, Watanabe, Junko, Sumiyoshi, Issei, Orimo, Akira, Takahashi, Kazuhisa

“…Metastasis-related events are the primary cause of cancer-related deaths, and circulating tumor cells (CTCs) have a pivotal role in metastatic relapse. CTCs…”
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Cancer‐associated fibroblast migration in non‐small cell lung cancers is modulated by increased integrin α11 expression by Iwai, Moe, Tulafu, Miniwan, Togo, Shinsaku, Kawaji, Hideya, Kadoya, Kotaro, Namba, Yukiko, Jin, Jin, Watanabe, Junko, Okabe, Takahiro, Hidayat, Moulid, Sumiyoshi, Issei, Itoh, Masayoshi, Koyama, Yu, Ito, Yasuhiko, Orimo, Akira, Takamochi, Kazuya, Oh, Shiaki, Suzuki, Kenji, Hayashizaki, Yoshihide, Yoshida, Koji, Takahashi, Kazuhisa

“…Cancer‐associated fibroblasts (CAFs) regulate cancer progression through the modulation of extracellular matrix (ECM) and cancer cell adhesion. While…”
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The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling by Omoto, Tomokatsu, Kim-Kaneyama, Joo-ri, Lei, Xiao-Feng, Orimo, Akira, Ohnishi, Koji, Yoshihara, Kosuke, Miyauchi, Aya, Li, Shuo, Gao, Lin, Umemoto, Takahiro, Tanaka, Junichi, Nakahara, Kenta, Takeya, Motohiro, Ishida, Fumio, Kudo, Shin-ei, Haraguchi, Shogo, Miyazaki, Takuro, Miyazaki, Akira

“…Carcinoma-associated fibroblasts (CAFs) influence tumor initiation, progression, and metastasis within the tumor-associated stroma. This suggests that CAFs…”
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Serum Levels of N- and C-ERC/Mesothelin and Clinicopathological Factors in Mesothelioma Patients and Those without Mesothelioma by Koyanagi, A I, Kajino, Kazunori, Nojiri, Shuko, Abe, Masaaki, Kobayashi, Toshiyuki, Sugitani, Yoshinobu, Yue, Liang, Ohtsuji, Naomi, Arakawa, Atsushi, Sato, Tadashi, Takahashi, Kazuhisa, Suzuki, Kenji, Orimo, Akira, Yao, Takashi, Hino, Okio

“…Objectives: ERC/mesothelin is a glycosylphosphatidylinositol (GPI)-anchor protein expressed in mesothelioma. A precursor protein is cleaved by proteases and an…”
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CD26 expression is attenuated by TGF‐β and SDF‐1 autocrine signaling on stromal myofibroblasts in human breast cancers by Mezawa, Yoshihiro, Daigo, Yataro, Takano, Atsushi, Miyagi, Yohei, Yokose, Tomoyuki, Yamashita, Toshinari, Morimoto, Chikao, Hino, Okio, Orimo, Akira

“…Human breast carcinoma‐associated fibroblasts (CAFs) increasingly acquire both transforming growth factor‐β (TGF‐β) and stromal cell‐derived factor‐1 (SDF‐1)…”
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Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer by Escudero-Esparza, Astrid, Bartoschek, Michael, Gialeli, Chrysostomi, Okroj, Marcin, Owen, Sioned, Jirström, Karin, Orimo, Akira, Jiang, Wen G, Pietras, Kristian, Blom, Anna M

“…Human CUB and Sushi multiple domains 1 (CSMD1) is a membrane-bound complement inhibitor suggested to act as a putative tumor suppressor gene, since allelic…”
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Transforming growth factor-β: Guardian of catabolic metabolism in carcinoma-associated fibroblasts by Khan, Husain Yar, Orimo, Akira

“…Comment on: Guido C, et al. Cell Cycle 2012; 11:3019-35…”
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Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity by Matsumura, Yuko, Ito, Yasuhiko, Mezawa, Yoshihiro, Sulidan, Kaidiliayi, Daigo, Yataro, Hiraga, Toru, Mogushi, Kaoru, Wali, Nadila, Suzuki, Hiromu, Itoh, Takumi, Miyagi, Yohei, Yokose, Tomoyuki, Shimizu, Satoru, Takano, Atsushi, Terao, Yasuhisa, Saeki, Harumi, Ozawa, Masayuki, Abe, Masaaki, Takeda, Satoru, Okumura, Ko, Habu, Sonoko, Hino, Okio, Takeda, Kazuyoshi, Hamada, Michiaki, Orimo, Akira

“…Emerging evidence supports the hypothesis that multicellular tumor clusters invade and seed metastasis. However, whether tumor-associated stroma induces…”
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The Inhibitory Effects of Anti-ERC/Mesothelin Antibody 22A31 on Colorectal Adenocarcinoma Cells, within a Mouse Xenograft Model by Taniguchi, Gentaro, Kajino, Kazunori, Momose, Shuji, Saeki, Harumi, Yue, Liang, Ohtsuji, Naomi, Abe, Masaaki, Shibuya, Tomoyoshi, Orimo, Akira, Nagahara, Akihito, Watanabe, Sumio, Hino, Okio

“…The expression of Renal Carcinoma (ERC)/mesothelin is enhanced in a variety of cancers. ERC/mesothelin contributes to cancer progression by modulating cell…”
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Emerging roles of the tumor-associated stroma in promoting tumor metastasis by Horimoto, Yoshiya, Polanska, Urszula M., Takahashi, Yuko, Orimo, Akira

“…The stroma in human carcinomas consists of extracellular matrix and various types of non-carcinoma cells, mainly leukocytes, endothelial cells, fibroblasts,…”
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