Search Results - "Orihashi, Yasushi"

Concentration-QTc analysis with two or more correlated baselines by Orihashi, Yasushi, Kumagai, Yuji

“…The relationship between drug concentration and QTc interval is typically evaluated by applying the standard analysis model proposed in a scientific whitepaper…”
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Concentration–QTc analysis for single arm studies by Orihashi, Yasushi, Ohwada, Shoichi, Kumagai, Yuji

“…Concentration–QTc (C–QTc) modeling is being increasingly used in phase 1 studies. For studies without a placebo arm (single arm studies), the scientific…”
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Multifaceted ORganizational InterventiONs (M-ORION) project for prevention of depression and anxiety among workers: study protocol for a five-arm cluster randomized controlled trial by Watanabe, Kazuhiro, Hikichi, Hiroyuki, Imamura, Kotaro, Sakuraya, Asuka, Yoshikawa, Toru, Izawa, Shuhei, Eguchi, Hisashi, Inoue, Akiomi, Yoshida, Kengo, Orihashi, Yasushi, Tsutsumi, Akizumi

“…Depression and anxiety are the most common mental health issues experienced by workers. Although organizational intervention has been extensively evaluated as…”
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Psychosocial factors predicting symptoms of depression and anxiety in allogeneic hematopoietic stem cell transplant recipients in Japan by Imamura, Takashi, Sudo, Takeshi, Orihashi, Yasushi, Takahashi, Yuki, Onishi, Yuichi, Onizuka, Makoto, Mikami, Katsunaka, Ueda, Yasunori, Yamamoto, Kenji

“…Objective We explored whether a patient’s psychosocial background before allogeneic hematopoietic stem cell transplantation (allo-HSCT) could predict the…”
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Iron Supplementation for Hypoferritinemia-Related Psychological Symptoms in Children and Adolescents by Mikami, Katsunaka, Akama, Fumiaki, Kimoto, Keitaro, Okazawa, Hideki, Orihashi, Yasushi, Onishi, Yuichi, Takahashi, Yuki, Yabe, Hiromasa, Yamamoto, Kenji, Matsumoto, Hideo

“…Background: Although some studies have described the association between serum ferritin levels and specific disorders in child and adolescent psychiatry, few…”
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Effective Tools to Predict Depression in Acute and Subacute Phase of Ischemic Stroke by Mikami, Katsunaka, Sudo, Takeshi, Orihashi, Yasushi, Kimoto, Keitaro, Mizuma, Atsushi, Uesugi, Tsuyoshi, Kawamura, Reina, Honma, Kazunari, Nagata, Eiichiro, Yamamoto, Kenji, Takizawa, Shunya, Matsumoto, Hideo, Robinson, Robert G

“…Objective:Despite the high frequency of depression in the first year following stroke, few studies have predicted risk of depression after the acute and…”
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Risks and renal outcomes of severe acute kidney injury in children with steroid-resistant nephrotic syndrome by Ishiwa, Sho, Sato, Mai, Kamei, Koichi, Nishi, Kentaro, Kanamori, Toru, Okutsu, Mika, Ogura, Masao, Sako, Mayumi, Ito, Shuichi, Orihashi, Yasushi, Ishikura, Kenji

“…Background Risks and renal outcomes of severe acute kidney injury (AKI) in children with steroid-resistant nephrotic syndrome (SRNS), particularly those who…”
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Efficacy and safety of single-dose ivermectin in mild-to-moderate COVID-19: the double-blind, randomized, placebo-controlled CORVETTE-01 trial by Wada, Tatsuhiko, Hibino, Makoto, Aono, Hiromi, Kyoda, Shunsuke, Iwadate, Yosuke, Shishido, Eri, Ikeda, Keisuke, Kinoshita, Nana, Matsuda, Yasuki, Otani, Sakiko, Kameda, Ryo, Matoba, Kenta, Nonaka, Miwa, Maeda, Mika, Kumagai, Yuji, Ako, Junya, Shichiri, Masayoshi, Naoki, Katsuhiko, Katagiri, Masato, Takaso, Masashi, Iwamura, Masatsugu, Katayama, Kazuhiko, Miyatsuka, Takeshi, Orihashi, Yasushi, Yamaoka, Kunihiro

“…To investigate whether ivermectin inhibits SARS-CoV-2 proliferation in patients with mild-to-moderate COVID-19 using time to a negative COVID-19 reverse…”
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Study design, statistical analysis, and interpretation of QT-prolonging effects of ICH-E14 by Orihashi, Yasushi

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Risk factors for wound dehiscence after surgery for epilepsy by Kagawa, Kota, Iida, Koji, Hashizume, Akira, Seyama, Go, Okamura, Akitake, Askoro, Rofat, Orihashi, Yasushi, Akita, Tomoyuki, Horie, Nobutaka

“…OBJECTIVE Wound dehiscence following craniotomy is a complication for which patients are subjected to additional procedures to achieve wound closure. During…”
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Novel concentration‐QTc models for early clinical studies with parallel placebo controls: A simulation study by Orihashi, Yasushi, Kumagai, Yuji, Shiosakai, Kazuhito

“…The QTc interval of the electrocardiogram is a pharmacodynamic biomarker for drug‐induced cardiac toxicity. The ICH E14 guideline Questions and Answers offer a…”
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NIMG-21. EARLY-STAGE GLIOBLASTOMA AND MOLECULAR ANALYSIS REVEAL THE RADIOLOGICAL INITIATION OF IDH WILDTYPE GLIOBLASTOMA by Shibahara, Ichiyo, Shigeeda, Ryota, Orihashi, Yasushi, Tanihata, Yoko, Fujitani, Kazuko, Hyakutake, Yuri, Toyoda, Mariko, Sato, Sumito, Hide, Takuichiro, Kumabe, Toshihiro

“…Abstract Glioblastoma (GB), IDH wildtype, is an aggressive and malignant tumor that necessitate early surgical intervention upon radiological suspicion…”
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Early Immunosuppressive Therapy and Ocular Complications in Pediatric and Young Adult Patients with Non-Infectious Uveitis at a Tertiary Referral Center in Japan by Sada, Ikuyo, Hiyama, Tomona, Orihashi, Yasushi, Doi, Takehiko, Yasumura, Junko, Kiuchi, Yoshiaki, Harada, Yosuke

“…To evaluate differences in the incidence of ocular complications among pediatric and young adult patients with non-infectious uveitis receiving…”
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Psychiatric Features of Children with Chronic Functional Constipation: Focusing on Individuals with Autism Spectrum Disorder by Akama, Fumiaki, Mikami, Katsunaka, Orihashi, Yasushi, Takase, Syunya, Hanawa, Kyuta, Nishikawa, Keita, Watanabe, Natsuru, Kimoto, Keitaro, Takahashi, Yuki, Onishi, Yuichi, Salas, Juan, Yamamoto, Kenji, Ueno, Shigeru

“…The present study aimed to assess the psychiatric characteristics of children with chronic functional constipation using the Aberrant Behavior…”
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Ventricular opening and cerebrospinal fluid circulation accelerate the biodegradation process of carmustine wafers suggesting their immunomodulation potential in the human brain by Shibahara, Ichiyo, Shibahara, Yukiko, Hagiwara, Hiroyuki, Watanabe, Takashi, Orihashi, Yasushi, Handa, Hajime, Inukai, Madoka, Hide, Takuichiro, Yasui, Yoshie, Kumabe, Toshihiro

“…Purpose Opening the ventricular system during glioblastoma surgery is often necessary, but the consequent effect on the tumor microenvironment of glioblastoma…”
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Iron Supplementation for Hypoferritinemia-Related Psychological Symptoms in Children and Adolescents by Katsunaka Mikami, Fumiaki Akama, Keitaro Kimoto, Hideki Okazawa, Yasushi Orihashi, Yuichi Onishi, Yuki Takahashi, Hiromasa Yabe, Kenji Yamamoto, Hideo Matsumoto

“…Background: Although some studies have described the association between serum ferritin levels and specific disorders in child and adolescent psychiatry, few…”
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Treatment rationale and protocol design: an investigator-initiated phase II study of combination treatment of nivolumab and TM5614, a PAI-1 inhibitor for previously treated patients with non-small cell lung cancer by Masuda, Takeshi, Hirata, Taizo, Sakamoto, Tomohiro, Tsubata, Yukari, Ichihara, Eiki, Kozuki, Toshiyuki, Shoda, Hiroyasu, Motonaga, Masanori, Yoshida, Takako, Fukutani, Miki, Tsuji-Takayama, Kazue, Tamura, Atsushi, Amagase, Harunobu, Fujihara, Hideki, Aoki, Gaku, Akita, Tomoyuki, Orihashi, Yasushi, Miyata, Toshio, Hattori, Noboru

“…There is no established standard 3 line treatment for patients with advanced non-small cell lung cancer (NSCLC). Although cytotoxic chemotherapeutic agents…”
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Effect of Back-Cut Point Needle Bevel Angle on Deterioration After Multiple Punctures in Central Vein Simulation by Urimoto, Genya, Suzuki, Takeshi, Matsuda, Mitsumasa, Ito, Kenzi, Orihashi, Yasushi, Suzuki, Toshiyasu

“…Multiple needle punctures during central venous line insertion can lead to serious complications. Needle deterioration owing to repeated punctures may be a…”
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Safety and Pharmacokinetics of DS‐1040 Drug‐Drug Interactions With Aspirin, Clopidogrel, and Enoxaparin by Limsakun, Tharin, Dishy, Victor, Mendell, Jeanne, Pizzagalli, Flavia, Pav, Joseph, Kochan, Jarema, Vandell, Alexander G., Rambaran, Curtis, Kobayashi, Fumiaki, Orihashi, Yasushi, Warren, Vance, McPhillips, Penny, Zhou, Jin

“…DS‐1040, a novel low‐molecular‐weight inhibitor of activated thrombin‐activatable fibrinolysis inhibitor, is under development for the treatment of…”
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Iron supplementation for hypoferritinemia-related psychological symptoms in children and adolescents by Mikami, Katsunaka, Akama, Fumiaki, Kimoto, Keitaro, Okazawa, Hideki, Orihashi, Yasushi, Onishi, Yuichi, Takahashi, Yuki, Yabe, Hiromasa, Yamamoto, Kenji, Matsumoto, Hideo

“…Background: Although some studies have described the association between serum ferritin levels and specific disorders in child and adolescent psychiatry, few…”
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